16 papers · ranked by Valyu relevance
Kwame Boamah-Addo, Robert E. Gaunt, Andrey Sarantsev
In this note, we consider the performance of the classic method of moments for parameter estimation of symmetric variance-gamma (generalized Laplace) distributions. We do this through both theoretical analysis (multivariate delta method) and a comprehensive simulation study with comparison to maximum likelihood…
Kensuke Tanioka, Kaoru Okuda, Satoru Hiwa, Tomoyuki Hiroyasu
In randomized clinical trials, we assumed the situation that the new treatment is not adequate compared to the control treatment as result. However, it is unknown if the new treatment is ineffective for all patients or if it is effective for only a subgroup of patients with specific characteristics. If such a subgroup…
Ariel Chen, Shachar Gat, Lior Ohana, Evgeni Yekimov + 2 more
The production of giant unilamellar vesicles (GUVs) plays a pivotal role in various scientific disciplines, particularly in the development of synthetic cells. While numerous methods exist for GUV preparation, the modified continuous droplet interface crossing encapsulation (cDICE) method offers the advantages of…
Andrew D. Bailey, Jason Talkish, Hongxu Ding, Haller Igel + 4 more
Nucleotides in RNA and DNA are chemically modified by numerous enzymes that alter their function. Eukaryotic ribosomal RNA (rRNA) is modified at more than 100 locations, particularly at highly conserved and functionally important nucleotides. During ribosome biogenesis, modifications are added at various stages of…
Ruikai Jia, Yusha Wang, Hua Ye, Xiaoshu Ma
gene synthesis sequencing using the long-read Oxford Nanopore Technologies (ONT) provides a cost-effective option for gene synthesis quality control. Despite the advantage of using long reads, however, accurate base calling is influenced by modified bases. We introduce a method for filtering abnormal modified base…
Alexandra Paul, Mario Falsaperna, Helen Lavender, Michelle Garrett + 1 more
The chemistry of aptamers is largely limited to natural nucleotides, and although modifications of nucleic acids can enhance target aptamer affinity, there has not been a technology for selecting the right modifications in the right locations because enzymatic amplification does not transmit sequence-specific…
Shunsuke Yamazaki, Kazutoshi Takahashi, Yutaka Matsuda
This study delves into the functional intricacies of lipoate ligase A (LplA), an enzyme showing great promise in bioconjugation due to its unique capacity for introducing azido groups into proteins without requiring a genetic tag. We aimed to enhance the understanding of LplA's functionality, particularly its substrate…
Authors not listed
The diffusion of CO2 and H2O in CALF-20 was examined at various concentrations and in N2 and He carrier gases. The data show that N2 has a measurable impact on the diffusion of CO2 and H2O in the pores of CALF-20. The results highlight the importance of considering N2 adsorption in CO2 capture materials and the effect…
Jorge Pereira, Rafael O. Ruiz
This work introduces a surrogate-based model for efficiently estimating the frequency response of dynamic mechanical metamaterials, particularly when dealing with large parametric perturbations and aperiodic substructures. The research builds upon a previous matrix interpolation method applied on top of a Craig-Bampton…
Yi Liu, Sebastian Bossert, Rui Wu, Dooti Roy + 2 more
'Qiqi Deng'] Bretz et al (2005) [1] proposed multiple Comparison Procedure and Modeling (MCPMod) method to design and analyze dose-finding study. Pinheiro (2014)[2] then generalized it to various types of endpoint, including but not limited to binary endpoint, survival endpoint, count data, and longitudinal data. The…
Michael Cheung, Anna Dimitrova, Tarik Benmarhnia
Modification Analyses in High-Dimensional Settings Authors: ['Michael Cheung' 'Anna Dimitrova' 'Tarik Benmarhnia'] A primary concern of public health researchers involves identifying and quantifying heterogeneous exposure effects across population subgroups. Understanding the magnitude and direction of these effects on…
Davi G. Accioli, Jerome Jouffroy
State and parameter estimation, along with fault detection, are three crucial estimation problems within the control systems community. Although different approaches have been proposed for each type of problem, the modulating function method proposes a more unified approach to all three problem classes, being used for…
Nadine Marlin, Peter J. Godolphin, Richard L. Hooper, Richard D. Riley + 1 more
3.1.1#### Comparison of one- vs. two-stage and common vs. random effects models for subgroup effects and interaction terms IPDMA of effect modification can either be performed in two stages, where analyses are performed within each trial and the summary measures combined, or in one stage, where individual level data…
Yasmine Marani, Ibrahima N’Doye, Taous‐Meriem Laleg‐Kirati
Dynamical models are often corrupted by model uncertainties, external disturbances, and measurement noise. These factors affect the performance of model-based observers and as a result, affect the closedloop performance. Therefore, it is critical to develop robust modelbased estimators that reconstruct both the states…
Ashwin P. Dani
—In this paper, a constrained parameter update law is derived in the context of adaptive control. The parameter update law is based on constrained optimization technique where a Lagrangian is formulated to incorporate the constraints on the parameters using inverse Barrier function. The constrained parameter update law…
Subham Choudhury, Ilias Toumpe, Oussama Gabouj, Jakob Sebastian Behler + 2 more
Generative machine learning methods that utilize neural networks to parameterize large-scale and near-genome-scale kinetic models have yielded significant efficiency gains in model construction, paving the way for high-throughput dynamic metabolism studies in biomedical and biotechnological applications. Nevertheless…