18 papers · ranked by Valyu relevance
Xiao Hu, James P. Charles, Turgay Akay, John R. Hutchinson + 1 more
'Silvia S. Blemker'] Background The mouse is one of the most widely used animal models to study neuromuscular diseases and test new therapeutic strategies. However, findings from successful pre-clinical studies using mouse models frequently fail to translate to humans due to various factors. Differences in muscle…
Daniel A Hagen, Francisco J Valero-Cuevas
Accurate predictions of tendon forces must consider musculotendon mechanics; specifically muscle fiber lengths and velocities. These are either predicted explicitly by simulating musculoskeletal dynamics or approximated from measured limb kinematics. The latter is complicated by the fact that tendon lengths and…
Kelly Rock, Odessa Addison, Vicki L. Gray, Robert M. Henshaw + 3 more
'Christopher Ward' 'Victoria Marchese' 'Peter Hauser'] Children with hematologic and oncologic health conditions are at risk of impaired skeletal muscle strength, size, and neuromuscular activation that may limit gross motor performance. A comprehensive assessment of neuromuscular function of these children is…
Matheus D. Pinto, James M. Wakeling, Javier A. Almonacid, Anthony J. Blazevich
Skeletal muscle architectural design strongly affects force-generating capacity and excursion range, and its functional importance to animal and human movement is well-founded. Traditionally, this ‘structure−function relation’ has been inferred when assessing a muscle’s architecture at rest, often using muscle images…
Edwin D.H.M. Reuvers, Huub Maas, Wendy Noort, Maarten F. Bobbert + 1 more
The average mechanical power output (AMPO) during a stretch-shortening cycle produced by a muscle depends on muscle length and stimulation over time. While the effects of cycle frequency and muscle length excursion on AMPO are well-known, several questions remain about the effects of muscle length and stimulation over…
Annika Kruse, Cintia Rivares, Guido Weide, Markus Tilp + 1 more
'Richard T. Jaspers'] Treatment strategies and training regimens, which induce longitudinal muscle growth and increase the muscles’ length range of active force exertion, are important to improve muscle function and to reduce muscle strain injuries in clinical populations and in athletes with limited muscle…
Eleftherios Kellis, Anthony J. Blazevich
Temporal biomechanical and physiological responses to physical activity vary between individual hamstrings components as well as between exercises, suggesting that hamstring muscles operate differently, and over different lengths, between tasks. Nevertheless, the force-length properties of these muscles have not been…
Cassandra Kramer, Emily J. Reedich, Hope McCann, Sadie Drouin + 13 more
The distribution of slow-and fast-twitch fiber types in a skeletal muscle heavily influences its physiology. Muscle biopsy studies indicate atypical fiber type composition and fiber size variation in children with cerebral palsy (CP), but subjects have variable treatment history and a variety of muscles affected, so…
Leander A. Vonk, Osman Esen, Daan Hoomoedt, Rajvi M.N. Balesar + 2 more
Ex vivo culture of isolated muscle fibers can serve as an important model for in vitro research on mature skeletal muscle fibers. Nevertheless, this model has limitations for long-term studies due to structural loss and dedifferentiation following prolonged culture periods. This study aimed to investigate how ex vivo…
Emmet A. Francis, Juliette Hamid, Anusha Kumar, Padmini Rangamani
The dynamics of calcium ions (Ca^2+^) in skeletal muscles link electrochemical activation and contractile force generation. An improved quantitative understanding of the mechanisms by which Ca^2+^ dynamics modulate force production is crucial for optimizing muscle performance. Recent experimental data suggest that…
Jiaxiang Xu, Bin Chen
Contradictory experimental reports on the relationship between efficiency and stimulation frequency have hindered mechanistic understanding in converting neural activity into mechanical work during muscle contraction. To resolve this issue, we develop a biophysical model integrating calcium-mediated excitation with a…
Benjamin F. Maier
| | Abstract/Kurzzusammenfassung | | v | | --- | --- | --- | --- | | | Publications | | vii | | 1 | Introduction | | 1 | | | 1.1 | Anatomy and Physiology of the Human Skeletal Muscle | 3 | | | 1.2 | Use-Cases and Requirements for Simulations Used in in-Silico Experiments | 5 | | | 1.3 | Related Work and Software | 7 |…
Jason J. Howard, Walter Herzog
This review will provide a comprehensive, up-to-date review of the current knowledge regarding the pathophysiology of muscle contractures in cerebral palsy. Although much has been known about the clinical manifestations of both dynamic and static muscle contractures, until recently, little was known about the…
Neil Ibata, Eugene M. Terentjev
Muscles sense internally generated and externally applied forces, responding to these in a coordinated hierarchical manner at different time scales. The center of the basic unit of the muscle, the sarcomeric M-band, is perfectly placed to sense the different types of load to which the muscle is subjected. In…
Authors not listed
Tissue engineering and regenerative medicine applications require the integration of multifunctional materials, offering appropriate mechanical cues and geometric guidance to support tissue-specific cell differentiation. In this context, supramolecular gel noodles formed by ionic cross-linking of pre-assembled micellar…
Koen K. Lemaire, Richard T. Jaspers, Dinant A. Kistemaker, A. J. “Knoek” van Soest + 1 more
'A. J. “Knoek” van Soest' 'Willem J. van der Laarse'] Currently available data on the energetics of isolated muscle preparations are based on bouts of less than 10 muscle contractions, whereas metabolic energy consumption is mostly relevant during steady state tasks such as locomotion. In this study we quantified the…
Aude Loumeaud, Philippe Pouletaut, Sabine F. Bensamoun, Daniel George + 1 more
'Daniel George' 'Simon Chatelin'] Abstract. Purpose: From the myofibrils to the whole muscle scale, muscle micro-constituents exhibit passive and active mechanical properties, potentially coupled to electrical, chemical, and thermal properties. Experimental characterization of some of these properties is currently not…
Fatemeh Jalali, Mohammad Ali Nazari, Arash Bahrami, Pascal Perrier + 1 more
'Yohan Payan'] Skeletal muscle modeling has a vital role in movement studies and the development of therapeutic approaches. In the current study, a Huxley-based model for skeletal muscle is proposed, which demonstrates the impact of impairments in muscle characteristics. This model focuses on three identified ions: H+…