20 papers · ranked by Valyu relevance
Jingyi Wen, Lingxuan Zou, Jiying Liu, Xi Guo + 17 more
High-resolution spatial transcriptomics (ST) data provide valuable insights into the molecular dynamics underlying complex biological processes. However, their widespread application remains limited due to high costs and technical challenges. Here, we present PRTS (Pathology-driven Reconstruction of Transcriptomic…
Damien Dandoy, Christophe Fremaux, Marie Henry de Frahan, Philippe Horvath + 3 more
'Philippe Horvath' 'Patrick Boyaval' 'Pascal Hols' 'Laetitia Fontaine'] Background In industrial fermentation processes, the rate of milk acidification by Streptococcus thermophilus is of major technological importance. The cell-envelope proteinase PrtS was previously shown to be a key determinant of the milk…
Imperial, Joseph Marvin, Madabushi, Harish Tayyar
Policy compliance assessment is a fundamental task of evaluating whether an input case strictly complies with a set of human-defined rules, more generally known as policies. In practice, human experts follow a systematic, step-by-step process to identify violations with respect to specific stipulations outlined in the…
Ahoefa Ablavi Awussi, Emeline Roux, Catherine Humeau, Zeeshan Hafeez + 9 more
'Bernard Maigret' 'Oun Ki Chang' 'Xavier Lecomte' 'Gérard Humbert' 'Laurent Miclo' 'Magali Genay' 'Clarisse Perrin' 'Annie Dary-Mourot' 'Nicole Hugouvieux-Cotte-Pattat'] Growth of the lactic acid bacterium Streptococcus thermophilus in milk depends on its capacity to hydrolyze proteins of this medium through its…
S. Rinehart, J.D. Long
Plant reproductive tissues (PRTs) can decrease (via reduced consumption) or increase (via numerical response) an omnivores consumption of animal prey. Although PRTs can increase predation pressure through numerical responses of omnivores, PRTs may also suppress predation by increasing omnivore interactions with…
Wentao Li, Binfei Zhang, Wenxing Kang, Boning Dong + 4 more
'Jinning Song' 'Yonghong Liu' 'Zhenqiang Liang'] Background The purpose of this study is to evaluate the effectiveness of gamma knife radiosurgery (GKRS) in the treatment of pineal region tumors (PRTs). Methods We retrospectively reviewed 147 cases of PRTs primarily treated with GKRS at our hospital between 1999 and…
Emily A Troyer, Jordan N Kohn, Monica Feliz R Castillo, Judith D Lobo + 10 more
'Judith D Lobo' 'Yaniel Ramirez Sanchez' 'Gavrila Ang' 'Anthony Cirilo' 'Juan Andrew Leal' 'Christopher Pruitt' 'Amanda L Walker' 'Kathleen L Wilson' 'Meredith A Pung' 'Laura S Redwine' 'Suzi Hong'] COVID-19 pandemic-related traumatic stress (PRTS) symptoms are reported in various populations, but risk factors in older…
Veronika Csillag, Marianne Hiriart Bizzozzero, Joyce Noble, Björn Reinius + 1 more
Understanding the routing of neuronal information requires the functional characterization of connections. Neuronal projections recruit large postsynaptic ensembles with distinct postsynaptic response types (PRTs). PRT is probed by low-throughput whole-cell electrophysiology and is not a selection criterion for…
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A substantial and growing body of research implicates protein‑arginine methyltransferases (PRMTs) in the pathogenesis of a range of human diseases, most prominently cancer. Their role – as oncoproteins or tumor suppressors – depends on both the cellular context and the specific type of malignancy. Starting from…
Fuyi Li, Cunshuo Fan, Tatiana T. Marquez-Lago, André Leier + 9 more
Post-translational modifications (PTMs) play very important roles in various cell signalling pathways and biological process. Due to PTMs’ extremely important roles, many major PTMs have been thoroughly studied, while the functional and mechanical characterization of major PTMs is well-documented in several databases.…
Matthew D. Mann, Min Wang, Josephine C. Ferreon, Michael P. Suess + 6 more
The progesterone receptor (PR) is a steroid-responsive nuclear receptor, expressed as two isoforms: PR-A and PR-B. The isoforms display distinct expression patterns and biological actions in reproductive target tissues and disruption of PR-A:PR-B signaling is associated with breast cancer development potentially by…
Chuang-Kai Chueh, Nilanjan Som, Lu-Chu Ke, Meng-Ru Ho + 2 more
Carboxyl (C)-terminal processing proteases (CTPs) participate in protective and regulatory proteolysis in bacteria. The PDZ domain is central to the activity of CTPs but plays inherently different regulatory roles. For example, the PDZ domain inhibits the activity of the signaling protease CtpB by blocking the active…
Marc Granado-González, C. Jesús-Valls, T. Lux, Tony Price + 1 more
'F. Sánchez'] Proton beam therapy can potentially offer improved treatment for cancers of the head and neck and in paediatric patients. There has been a sharp uptake of proton beam therapy in recent years as improved delivery techniques and patient benefits are observed. However, treatments are currently planned using…
Felix Ulrich-Pur, T. Bergauer, Alexander Burker, A. Hirtl + 3 more
'C. Irmler' 'Stefanie Kaser' 'F. M. Pitters'] Abstract. Particle therapy is an established method to treat deep-seated tumours using accelerator-produced ion beams. For treatment planning, the precise knowledge of the relative stopping power (RSP) within the patient is vital. Conversion errors from x-ray computed…
Devon Field, Stuart Warriner, Megan Wright
Fluorescent ligands for G-protein coupled receptors (GPCRs) are valuable tools for studying the expression, pharmacology and modulation of these therapeutically important proteins in living cells. Here we report a photocrosslinking fluorescent chemical probe for Formyl peptide receptor 1 (FPR1), a critical component of…
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Furin is a calcium-dependent endopeptidase. It is found in all vertebrates and many invertebrates. It is localized in the Golgi apparatus, and in the extra cellular space. It functions in the biosynthesis of a diverse group of cellular proteins that includes hormones, growth factors, matrix metalloproteases, and…
Bryon Drown, Kevin Jooß, Rafael Melani, Cameron Lloyd-Jones + 2 more
A functional understanding of the human body requires structure-function studies of proteins at scale. The chemical structure of proteins is controlled at the transcriptional, translational, and post-translational levels, creating a variety of products with modulated functions within the cell. The term “proteoform”…
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Comprehensive characterisation of monoclonal antibody (mAb) charge heterogeneity is essential for ensuring product quality, maintaining batch consistency, and supporting biosimilar development. Charge variant analysis (CVA) is widely used to separate acidic and basic proteoforms from the main species. However…
J. Werner, F. Pennazio, Piergiorgio Cerello, Elisa Fiorina + 8 more
Proton therapy's full potential is limited by uncertainties that prevent optimal dose distribution. Monitoring techniques can reduce these uncertainties and enable adaptive treatment planning. Spatiotemporal Emission Reconstruction from Prompt-Gamma Timing (SER-PGT) is a promising method that provides insights into…
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In philosophy and science, a first principle is a basic proposition or assumption that cannot be deduced from any other proposition or assumption. Ancient Greek philosophy Aristotle defined the first principle as “the first basis from which a thing is known.” First principles thinking (or reasoning from first…