21 papers · ranked by Valyu relevance
Jingyi Wen, Lingxuan Zou, Jiying Liu, Xi Guo + 17 more
High-resolution spatial transcriptomics (ST) data provide valuable insights into the molecular dynamics underlying complex biological processes. However, their widespread application remains limited due to high costs and technical challenges. Here, we present PRTS (Pathology-driven Reconstruction of Transcriptomic…
Ahoefa Ablavi Awussi, Emeline Roux, Catherine Humeau, Zeeshan Hafeez + 9 more
'Bernard Maigret' 'Oun Ki Chang' 'Xavier Lecomte' 'Gérard Humbert' 'Laurent Miclo' 'Magali Genay' 'Clarisse Perrin' 'Annie Dary-Mourot' 'Nicole Hugouvieux-Cotte-Pattat'] Growth of the lactic acid bacterium Streptococcus thermophilus in milk depends on its capacity to hydrolyze proteins of this medium through its…
Imperial, Joseph Marvin, Madabushi, Harish Tayyar
Policy compliance assessment is a fundamental task of evaluating whether an input case strictly complies with a set of human-defined rules, more generally known as policies. In practice, human experts follow a systematic, step-by-step process to identify violations with respect to specific stipulations outlined in the…
Emily A Troyer, Jordan N Kohn, Monica Feliz R Castillo, Judith D Lobo + 10 more
'Judith D Lobo' 'Yaniel Ramirez Sanchez' 'Gavrila Ang' 'Anthony Cirilo' 'Juan Andrew Leal' 'Christopher Pruitt' 'Amanda L Walker' 'Kathleen L Wilson' 'Meredith A Pung' 'Laura S Redwine' 'Suzi Hong'] COVID-19 pandemic-related traumatic stress (PRTS) symptoms are reported in various populations, but risk factors in older…
Zeeshan Hafeez, Sophie Beaubier, Arnaud Aymes, Ségolène Christophe + 4 more
'Samina Akbar' 'Romain Kapel' 'Laurent Miclo' 'Alberto Cepeda Sáez'] Lactic acid bacteria are well known for hydrolyzing milk proteins, but their application to plant proteins remains limited. This study evaluated the ability of the cell-wall-anchored PrtS protease from two Streptococcus thermophilus strains to…
Yaoyao Han, Xinyao Dou, Sew Peak-Chew, Sven Truckenbrodt + 2 more
AMPA receptor (AMPAR) signalling underlies long-term potentiation (LTP), a cellular mechanism for learning that selectively involves GluA1-type AMPARs through incompletely understood mechanisms. Here, we report a key role for the auxiliary subunit PRRT1/SynDIG4 in LTP. Cryo-EM structures of hippocampal AMPARs reveal…
Veronika Csillag, Marianne Hiriart Bizzozzero, Joyce Noble, Björn Reinius + 1 more
Understanding the routing of neuronal information requires the functional characterization of connections. Neuronal projections recruit large postsynaptic ensembles with distinct postsynaptic response types (PRTs). PRT is probed by low-throughput whole-cell electrophysiology and is not a selection criterion for…
Marc Granado-González, C. Jesús-Valls, T. Lux, Tony Price + 1 more
'F. Sánchez'] Proton beam therapy can potentially offer improved treatment for cancers of the head and neck and in paediatric patients. There has been a sharp uptake of proton beam therapy in recent years as improved delivery techniques and patient benefits are observed. However, treatments are currently planned using…
Bo Liu, Benjamin Fair, Zhiling Kuang, Zhichao Tang + 9 more
Prion diseases are fatal neurodegenerative disorders driven by prion protein (PrP) misfolding, and lowering cellular PrP represents a promising therapeutic strategy. Here we report a small-molecule approach that reduces PrP by modulating pre-mRNA splicing of the PRNP gene. Through chemical modification of the…
Elmir Omerovic, Mark Petrie, Björn Redfors, Stephen Fremes + 15 more
In an era focused on value-based healthcare, the quality of healthcare and resource allocation should be underpinned by empirical evidence. Pragmatic clinical trials (pRCTs) are essential in this endeavor, providing randomized controlled trial (RCT) insights that encapsulate real-world effects of interventions. The…
Authors not listed
A substantial and growing body of research implicates protein‑arginine methyltransferases (PRMTs) in the pathogenesis of a range of human diseases, most prominently cancer. Their role – as oncoproteins or tumor suppressors – depends on both the cellular context and the specific type of malignancy. Starting from…
Veronika Csillag, JC Noble, Daniela Calvigioni, Björn Reinius + 1 more
Neuronal pathways recruit large postsynaptic populations and maintain connections via distinct postsynaptic response types (PRTs). Until recently, PRTs were only accessible as a selection criterion for single-cell RNA-sequencing (scRNA-seq) through probing by low-throughput whole-cell electrophysiology. To overcome…
Matthew D. Mann, Min Wang, Josephine C. Ferreon, Michael P. Suess + 6 more
The progesterone receptor (PR) is a steroid-responsive nuclear receptor, expressed as two isoforms: PR-A and PR-B. The isoforms display distinct expression patterns and biological actions in reproductive target tissues and disruption of PR-A:PR-B signaling is associated with breast cancer development potentially by…
Bryon Drown, Kevin Jooß, Rafael Melani, Cameron Lloyd-Jones + 2 more
A functional understanding of the human body requires structure-function studies of proteins at scale. The chemical structure of proteins is controlled at the transcriptional, translational, and post-translational levels, creating a variety of products with modulated functions within the cell. The term “proteoform”…
Felix Ulrich-Pur, T. Bergauer, Alexander Burker, A. Hirtl + 3 more
'C. Irmler' 'Stefanie Kaser' 'F. M. Pitters'] Abstract. Particle therapy is an established method to treat deep-seated tumours using accelerator-produced ion beams. For treatment planning, the precise knowledge of the relative stopping power (RSP) within the patient is vital. Conversion errors from x-ray computed…
Asvin KK Lakkaraju, Oliver Tejero, Ramon Guixà-González, Elena De Cecco + 8 more
In prion diseases, the cellular prion protein PrP^C^ is converted into aggregates of PrP^Sc^, leading to profound neurotoxicity through largely unknown mechanisms. Here we report that the cellular prion protein PrP^C^ acts as an antagonist of the adhesion G protein-coupled receptor (GPCR) Adgrd1. When overexpressed in…
Devon Field, Stuart Warriner, Megan Wright
Fluorescent ligands for G-protein coupled receptors (GPCRs) are valuable tools for studying the expression, pharmacology and modulation of these therapeutically important proteins in living cells. Here we report a photocrosslinking fluorescent chemical probe for Formyl peptide receptor 1 (FPR1), a critical component of…
Reem S. Alotaibi, Maha F. Algabbani, Afaf A. M. Shaheen, Alaa M. Albishi + 1 more
'Alaa M. Albishi' 'Muneera M. Almurdi'] Background The Pediatric Reach Tests (PRTs) assess balance while standing-the Functional Reach Test (FRT) and Lateral Reach Test (LRT)-and in a sitting position-the Modified Functional Reach Test (MFRT) and Modified Lateral Reach Test (MLRT). Normative values have not been fully…
Authors not listed
Furin is a calcium-dependent endopeptidase. It is found in all vertebrates and many invertebrates. It is localized in the Golgi apparatus, and in the extra cellular space. It functions in the biosynthesis of a diverse group of cellular proteins that includes hormones, growth factors, matrix metalloproteases, and…
Authors not listed
Comprehensive characterisation of monoclonal antibody (mAb) charge heterogeneity is essential for ensuring product quality, maintaining batch consistency, and supporting biosimilar development. Charge variant analysis (CVA) is widely used to separate acidic and basic proteoforms from the main species. However…
Ali Al Asadi, S.A. Hosseini, Azadeh Akhavanallaf, Naser Vosoughi + 1 more
'Habib Zaidi'] In this study, two proton beam delivery designs, i.e. passive scattering proton therapy (PSPT) and pencil beam scanning (PBS), were quantitatively compared in terms of dosimetric indices. The GATE Monte Carlo (MC) particle transport code was used to simulate the proton beam system; and the developed…