26 papers · ranked by Valyu relevance
Fatima-Zahra Belouadha, Hajar Omrana, Ounsa Roudiès
In a global business context with continuous changes, the enterprises have to improve their productivity and their brand image according to a given strategy. They are expected to face big challenges in order to overcome hard competition and meet the growing demands of clients. Indeed, they should capitalize on the…
Anzalee Khan, Aditya Ghose, Hoa Khanh Dam, Arsal Syed
Process analytics approaches allow organizations to support the practice of Business Process Management and continuous improvement by leveraging all process-related data to extract knowledge, improve process performance and support decision making across the organization. Process execution data once collected will…
Niels Grewe
Background Biomedical ontologies usually encode knowledge that applies always or at least most of the time, that is in normal circumstances. But for some applications like phenotype ontologies it is becoming increasingly important to represent information about aberrations from a norm. These aberrations may be…
Korbinian T. Metz, Faruk Civelek, André Zimmermann, Duc Truong Pham
Microsystem technology (MST) and micro-electro-mechanical systems (MEMS) are key technologies that continually introduce new application opportunities. Increasing complexity and individualization require systematic process development to avoid errors and delays. While existing methods for process development address…
Geert Poels, Félix García, Francisco Ruíz, Mario Piattini
Process maps provide a high-level overview of an organization's business processes. While used for many years in different shapes and forms, there is little shared understanding of the concept and its relationship to enterprise architecture. In this report, we position the concept of business process map within the…
Bianka Bakullari, Jules van Thoor, Dirk Fahland, Wil M. P. van der Aalst
'Wil M. P. van der Aalst'] Abstract. Business processes may face a variety of problems due to the number of tasks that need to be handled within short time periods, resources' workload and working patterns, as well as bottlenecks. These problems may arise locally and be short-lived, but as the process is forced to…
Carlos Fernandez-Llatas, Aroa Lizondo, Eduardo Monton, Jose-Miguel Benedi + 2 more
'Jose-Miguel Benedi' 'Vicente Traver' 'Kourosh Khoshelham'] The definition of efficient and accurate health processes in hospitals is crucial for ensuring an adequate quality of service. Knowing and improving the behavior of the surgical processes in a hospital can improve the number of patients that can be operated on…
Wil M. P. van der Aalst, Tobias Brockhoff, Anahita Farhang Ghahfarokhi, Mahsa Pourbafrani + 2 more
'Anahita Farhang Ghahfarokhi' 'Mahsa Pourbafrani' 'Merih Seran Uysal' 'Sebastiaan J. van Zelst'] > Abstract. Operational processes in production, logistics, material handling, maintenance, etc., are supported by cyber-physical systems combining hardware and software components. As a result, the digital and the physical…
Julia Baß, Michael Winter, Rüdiger Pryss, Manfred Reichert + 1 more
'Daniele Corbo'] The study of complex process models often encounters challenges in terms of comprehensibility. This paper explores using modularization as a strategy to mitigate such challenges, notably the reduction in complexity. Previous research has delved into the comprehensibility of modularized process models…
Marcus Fischer, Adrian Hofmann, Florian Imgrund, Christian Janiesch + 1 more
'Axel Winkelmann'] Digital transformation forces companies to rethink their processes to meet current customer needs. Business Process Management (BPM) can provide the means to structure and tackle this change. However, most approaches to BPM face restrictions on the number of processes they can optimize at a time due…
Authors not listed
Rapid and robust simulation of chemical processes is critical to conduct process design, optimization, techno-economic analysis, and sustainability analysis. Yet, efficiently solving simulation models remains a challenge due to the highly coupled and nonlinear nature of the underlying algebraic equations that capture…
Authors not listed
Self-driving laboratories (SDLs) promise accelerated scientific discovery and product development by closing the loop between robotic execution and AI/ML-driven decision making. In practice, however, SDL orchestration remains fragmented; workflows are typically encoded as laboratory-specific scripts or bespoke…
Stephan O. Adler, Edda Klipp
Life depends on the input of energy, either directly provided by sunlight or in form of high-energy matter. The rules and conditions for the conversion of chemical or electromagnetic energy into living structure and all the processes related with life are governed by the laws of thermodynamics. Hence, to understand the…
Gabriele Micali, Jacopo Grilli, Matteo Osella, Marco Cosentino Lagomarsino
More in general, following the pioneering views of Boye and Norstrom , our findings support a change of perspective on the cell cycle. We can draw a comparison with the way cell cycle is described in animal cells. A prevalent narrative of the cell cycle, particularly for (higher) eukaryotes, is a succession of…
Helen Masson, Jasmine Tat, Pablo Di Giusto, Athanasios Antonakoudis + 12 more
The secretory pathway processes >30% of mammalian proteins, orchestrating their synthesis, modification, trafficking, and quality control. However, its complexity— spanning multiple organelles and dependent on coordinated protein interactions—limits our ability to decipher how protein secretion is controlled in…
Erin Looney, Andre Buscariolli, Maria Yang, Geoffrey Raymond + 2 more
Hardware-based startups risk having longer times-to-market, deterring investment in critical fields such as cleantech, medical devices, and automation. We interviewed 55 leaders at hardware startups, mapped their development timelines, and found prototyping to be the longest development step (median of 19 weeks per…
Authors not listed
This paper presents GLAS (Git-based Lab Automated Scheduler or Get Lab Automation Simplified), an open-source, robust, and highly expandable Git-based architecture designed for laboratory automation. GLAS can be deployed in both partially and fully automated experimental science laboratories, enabling the development…
Miguel Hernández-del-Valle, Jorge Ilarraza-Zuazo, Enrique Dios-Lázaro, Javier Rubio + 2 more
The development of novel polymer-based nanocomposites necessitates the experimental preparation and characterization of numerous compositions to identify optimal formulations. For thermoplastic-based materials, the compounding process typically involves the labor-intensive tasks of dispensing, weighing, mixing, and…
Dušan Živković, Angelique Sanchez Dafun, Thomas Menneteau, Adrien Schahl + 9 more
During spermatogenesis, spermatogonia undergo a series of mitotic and meiotic divisions on their path to spermatozoa. To achieve this, a succession of complex processes requiring high proteolytic activity are in part orchestrated by the proteasome. The spermatoproteasome (s20S) is a proteasome subtype specific to the…
Michael Statt, Kristopher Brown, Santosh Suram, Linda Hung + 3 more
In this work, we present DBgen, a Python library that provides a framework for defining extract-transform-load (ETL) pipelines to create and populate SQL databases. DBgen is most useful when the underlying data has complex relationships, requires multi-step analysis, is large-scale, and the type of data being collected…
Sarah Cohen-Boulakia, Jiuqiang Chen, Paolo Missier, Carole Goble + 2 more
'Alan R Williams' 'Christine Froidevaux'] Background Scientific workflows management systems are increasingly used to specify and manage bioinformatics experiments. Their programming model appeals to bioinformaticians, who can use them to easily specify complex data processing pipelines. Such a model is underpinned by…
Authors not listed
Self-organizing tissues, such as organoids, offer transformative potential beyond healthcare by enabling the sustainable production of advanced materials. Resource scarcity and global warming drive the need for innovative fabrication solutions. This prospective review explores developmental biology as a manufacturing…
Quentin Vagne, Jean-Patrick Vrel, Pierre Sens
The design principles dictating the spatio-temporal organization of eukaryotic cells, and in particular the mechanisms controlling the self-organization and dynamics of membrane-bound organelles such as the Golgi apparatus, remain elusive. Although this organelle was discovered 120 years ago, such basic questions as…
Bishimbayeva N.K., Rakhimova E.V.
Degrading cells of wheat and barley callus have all known ultrastructural features, which are characteristic for apoptotic cells: intense vacuolization, increasing the size of the nucleus, cupped invaginations of plastids, mitochondria saving until the last stages of cell degradation and the formation of vesicles…
Florent Figon, Ilse Hurbain, Xavier Heiligenstein, Sylvain Trépout + 5 more
Pigment organelles of vertebrates belong to the lysosome-related organelle (LRO) family, of which melanin-producing melanosomes are the prototypes. While their anabolism has been extensively unraveled through the study of melanosomes in skin melanocytes, their catabolism remains poorly known. Here, we tap into the…
Björn Heinemann, Patrick Künzler, Hans-Peter Braun, Tatjana M. Hildebrandt
During dehydration cellular proteostasis as well as amino acid homeostasis are severely challenged, since the decrease in photosynthesis induces massive proteolysis. Thus, we selected progressive drought stress in Arabidopsis thaliana as a model to investigate the balance between protein and free amino acid homeostasis…