24 papers · ranked by Valyu relevance
Xiaohan Zhang, Cen Zhang, Xinghua Li, Zhengjie Du + 6 more
'Yaowen Zheng' 'Yeting Li' 'Bing Mao' 'Yang Liu' 'Robert H. Deng'] XIAOHAN ZHANG∗† , Xidian University, China CEN ZHANG∗ , Nanyang Technological University, Singapore XINGHUA LI‡ , Xidian University, China ZHENGJIE DU and BING MAO, Nanjing University, China YUEKANG LI and YAOWEN ZHENG, Nanyang Technological University…
Harald Lampesberger
The evolution of Web and service technologies has led to a wide landscape of standards and protocols for interaction between loosely coupled software components. Examples range from Web applications, mashups, apps, and mobile devices to enterprise-grade services. Cloud computing is the industrialization of service…
Yanping Chen, Qinghua Zheng, Ping Chen
The current computer programmings encapsulate attributes and behaviours into objects, but miss the mechanism to support the connection among objects. A programming paradigm is presented to connect all objects. The connection supports communications. Protocols are defined to coordinate the behaviours between objects…
Tabitha C. Cowell, Noah R. Guillome, Matthew L. Cope-Arguello, Neha N. Prasad + 1 more
Here, we present a protocol for the transformation of Ralstonia solanacearum species complex (RSSC) strains by calcium chloride-induced chemical competence. We include a step-by-step protocol with media and solution recipes, quantitative results of the protocol’s efficacy for four of five tested RSSC strains, and an…
Shameng Wen, Qingkun Meng, Chao Feng, Chaojing Tang + 1 more
Network protocol vulnerability detection plays an important role in many domains, including protocol security analysis, application security, and network intrusion detection. In this study, by analyzing the general fuzzing method of network protocols, we propose a novel approach that combines network traffic analysis…
Jacek Wytrębowicz, Krzysztof Cabaj, Jerzy Krawiec, Claudio Savaglio
There are a dozen messaging protocols proposed for IoT systems. Choosing one for a new design is complicated, and a non-optimal selection can result in slower development and higher design costs. This paper aims to help select appropriate protocols, considering IoT applications’ specificity and communication…
Jinze Du, Rui Tang, Tao Feng, Omprakash Kaiwartya
The combination of in-vehicle networks and smart car devices has gradually developed into Intelligent Connected Vehicles (ICVs). Through the vehicle security protocol, ICVs can quickly realize communication transmission. However, with the more frequent connections between smart in-vehicle devices and the network, the…
Arijit Dasgupta, Yi-Xue Yan, Clarence Ong, Jenn-Yue Teo + 1 more
'Chia-Wei Lim'] Abstract—The ability to analyse and differentiate network protocol traffic is crucial for network resource management to provide differentiated services by Telcos. Automated Protocol Analysis (APA) is crucial to significantly improve efficiency and reduce reliance on human experts. There are numerous…
Kurt Weiss, Jan Huisken, Vesselina Bakalov, Michelle Engle + 9 more
Selecting and implementing a tissue-clearing protocol is challenging. Established more than 100 years ago, tissue clearing is still a rapidly evolving field of research. There are currently many published protocols to choose from, and each performs better or worse across a range of key evaluation factors (e.g., speed…
Yu Long Fu, Xiao Long Xin
The security of protocol implementation is important and hard to be verified. Since the penetration testing is usually based on the experience of the security tester and the specific protocol specifications, a formal and automatic verification method is always required. In this paper, we propose an extended model of…
Harshadkumar B. Prajapati, Vipul K. Dabhi
—Grid computing has attracted many researchers over a few years, and as a result many new protocols have emerged and also evolved since its inception a decade ago. Grid protocols play major role in implementing services that facilitate coordinated resource sharing across diverse organizations. In this paper, we provide…
Authors not listed
Protein-ligand binding affinity prediction is a key aspect in computational small molecule drug discovery. Several recent studies have demonstrated that molecular simulations based on alchemical absolute binding free-energy (ABFE) calculations are an accurate and broadly applicable tool for this purpose. However, the…
Shihao Jiang, Yuxin Zhang, Junqiang Li, Hongfang Yu + 2 more
'Gang Sun'] As one of the most successful and effective software testing techniques in recent years, fuzz testing has uncovered numerous bugs and vulnerabilities in modern software, including network protocol software. In contrast to other fuzzing targets, network protocol software exhibits its distinct characteristics…
Jacek Stój, Anne-Lena Kampen, Rafał Cupek, Ireneusz Smołka + 2 more
'Marek Drewniak' 'Carlo Alberto Avizzano'] Dedicated fieldbuses were developed to provide temporal determinisms for industrial distributed real-time systems. In the early stages, communication systems were dedicated to a single protocol and generally supported a single service. Industrial Ethernet, which is used today…
Chao Yuan, Jinze Du, Min Yue, Tao Ma
The control network is an important supporting environment for the control system of the heavy ion accelerator in Lanzhou (HIRFL). It is of great importance to maintain the accelerator system’s network security for the stable operation of the accelerator. With the rapid expansion of the network scale and the increasing…
Tabitha C. Cowell, Noah R. Guillome, Matthew L. Cope-Arguello, Neha N. Prasad + 1 more
Here, we present a protocol for the transformation of Ralstonia solanacearum species complex (RSSC) strains by calcium chloride-induced chemical competence. We include a step-by-step protocol with media and solution recipes, quantitative results of the protocol’s efficacy for four of five tested RSSC strains, and an…
Abdulmutalib Masaud-Wahaishi, Hamada Ghenniwa
Healthcare industry is facing a major reform at all levels-locally, regionally, nationally, and internationally. Healthcare services and systems become very complex and comprise of a vast number of components (software systems, doctors, patients, etc.) that are characterized by shared, distributed and heterogeneous…
Martin Amezcua, Léa El Khoury, David Mobley
The SAMPL challenges focus on testing and driving progress of computational methods to help guide pharmaceutical drug discovery. However, assessment of methods for predicting binding affinities is often hampered by computational challenges such as conformational sampling, protonation state uncertainties, variation in…
Frederikke Isa Marin, Kristoffer Enøe Johansson, Charlotte O’Shea, Kresten Lindorff-Larsen + 1 more
Computational protein design has taken big strides over the recent years, however, the tools available are still not at a state where a sequence can be designed to fold into a given protein structure at will and with high probability. We have here applied a recent release of Rosetta Design to redesign a set of…
Martin Amezcua, David Mobley
The SAMPL challenges focus on testing and driving progress of computational methods to help guide pharmaceutical drug discovery. However, assessment of methods for predicting binding affinities is often hampered by computational challenges such as conformational sampling, protonation state uncertainties, variation in…
Li Li, Jun Pang, Yang Liu, Jun Sun + 1 more
—A long-standing research problem in security protocol design is how to efficiently verify security protocols with tamper-resistant global states. In this paper, we address this problem by first proposing a protocol specification framework, which explicitly represents protocol execution states and state…
baiqing li, Hongming Chen
Proteolysis targeting chimeras (PROTACs), have emerged as an effective therapeutic modality by harnessing the ubiquitin-proteasome system to selectively induce targeted protein degradation, with the potential to modulate traditional undruggable targets. Due to its hetero-bifunctional characteristics, in which a linker…
Nathan M. Lim, Meghan Osato, Gregory L. Warren, David L. Mobley
Part of early stage drug discovery involves determining how molecules may bind to the target protein. Through understanding where and how molecules bind, chemists can begin to build ideas on how to design improvements to increase binding affinities. In this retrospective study, we compare how computational approaches…
Lin Song, Tai-Sung Lee, Chun Zhu, Darrin M. York + 1 more
We computed relative binding free energies using GPU accelerated Thermodynamic Integration (GPU-TI) on a dataset originally assembled by Schrödinger, Inc.. Using their GPU enabled free energy code (FEP+) and the OPLS2.1 force field combined with REST2 enhanced sampling approach, these authors obtained an overall MUE of…