18 papers · ranked by Valyu relevance
Yukiko Kikuchi, Mohammed Uddin, Joris A. Veltman, Sara Wells + 1 more
Significant progress has been made in elucidating the genetic underpinning of Autism Spectrum Disorder (ASD). This childhood-onset chronic disorder of cognition, communication and behaviour ranks among the most severe from a public health perspective, and it is therefore hoped that new discoveries will lead to better…
Luke Yerbury, Ricardo J. G. B. Campello, G. C. Livingston, Mark Goldsworthy + 1 more
Approaches Authors: ['Luke Yerbury' 'Ricardo J. G. B. Campello' 'G. C. Livingston' 'Mark Goldsworthy' 'Lachlan O’Neil'] Relative Validity Indices (RVIs) such as the Silhouette Width Criterion, Calinski-Harabasz and Davie's Bouldin indices are the most popular tools for evaluating and optimising applications of…
Slavé Petrovski, Ayal B. Gussow, Quanli Wang, Matt Halvorsen + 5 more
'Yujun Han' 'William H. Weir' 'Andrew S. Allen' 'David B. Goldstein' 'Chris Cotsapas'] Noncoding sequence contains pathogenic mutations. Yet, compared with mutations in protein-coding sequence, pathogenic regulatory mutations are notoriously difficult to recognize. Most fundamentally, we are not yet adept at…
Jeong Yeon Kim, Kyung Sook Yang, Youseung Chung, Ki-Byung Lee + 4 more
'Jin Woong Suh' 'Sun Bean Kim' 'Jang Wook Sohn' 'Young Kyung Yoon'] Background The diagnosis of respiratory viral infections (RVIs) in critically ill patients is important for determining treatment options and adhering to infection-control protocols. However, data on the incidence and occurrence patterns of RVIs are…
Shiraz Maskatia, Mary K Olive, Nicholas A Dodd, Rajesh Krishnamurthy + 4 more
The right ventricular infundibular sparing approach (RVIS) to repair tetralogy of Fallot (TOF) avoids a ventricular incision used in the transventricular (TV) approach. Recent data has demonstrated better global right ventricular systolic function in patients who underwent RVIS compared to those who had a TV repair…
Andreis Lau, Zhan Yang, Bo Wu, Zijie Qiu + 2 more
Over the past two decades, high-performance materials with aggregation-induced emission (AIE) characteristics have emerged as indispensable components in modern functional materials science. Among them, AIEgens based on the restriction of intramolecular rotation (RIR) mechanism have been thoroughly studied and…
Daniele Lapa, Silvia Pauciullo, Ida Ricci, Anna Rosa Garbuglia + 5 more
Rift Valley fever is a vector-borne zoonotic disease caused by the Rift Valley fever virus (Phlebovirus genus) listed among the eight pathogens included in the Bluepoint list by the WHO. The transmission is mainly vehicled by Aedes and Culex mosquito species. Symptoms of the disease are varied and non-specific, making…
Fajar Budi Lestari, Sompong Vongpunsawad, Nasamon Wanlapakorn, Yong Poovorawan
'Yong Poovorawan'] Background Rotaviruses (RVs) are recognized as a major cause of acute gastroenteritis (AGE) in infants and young children worldwide. Here we summarize the virology, disease burden, prevalence, distribution of genotypes and seasonality of RVs, and the current status of RV vaccination in Southeast Asia…
Michaela J. Conley, Jude M. Short, Joshua Hutchings, Andrew M. Burns + 9 more
Human respiratory syncytial virus (RSV) causes severe respiratory illness in children and the elderly. Treatments for RSV disease are however limited and efforts to produce an effective vaccine have so far been unsuccessful. Understanding RSV virion structure is an important prerequisite for developing interventions to…
Elysse N. Grossi-Soyster, Justin Lee, Charles H. King, A. Desiree LaBeaud + 1 more
Rift Valley fever virus (RVFV) is a zoonotic phlebovirus that can be transmitted to humans or livestock by mosquitoes or through direct contact with contaminated bodily fluids and tissues. Exposure to bodily fluids and tissues varies by types of behaviors engaged for occupational tasks, homestead responsibilities, or…
Aitor Nogales, Celia Alonso, Sandra Moreno, Gema Lorenzo + 3 more
Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic disease that causes severe disease in both domestic and wild ungulates and humans, making it a significant threat to livestock and public health. The RVFV genome consists of three single-stranded, negative-sense RNA segments differing in size: Small (S)…
julio coll
The respiratory syncytial virus (RSV) causes abundant annual fatalities on young children and elder adults by infecting human cells mediated by RSV fusion (F) surface homotrimeric proteins. Despite their RSV fusion in vitro inhibitors, anti-F therapeutic molecules are not yet clinically available because of emergent…
Thulaganyo Domfe, Zikhona Njengele-Tetyana, Nikiwe Mhlanga, Phumlani Tetyana + 4 more
'Phumlani Tetyana' 'Amanda Skepu' 'Jane Catherine Ngila' 'Lucky Mashudu Sikhwivhilu' 'Bill Rodriguez'] Rift Valley fever (RVF) is a mosquito-borne zoonotic disease that is caused by the Rift Valley fever virus (RVFV); Bunyaviridae: Phlebovirus. RVF disease can affect several different species, including ruminants…
F. Cersullo, F. Wildi, Bruno Chazelas, F. Pepe
Context. The field of exoplanet research is moving towards the detection and characterization of habitable planets. These exo-Earths can be easily found around low-mass stars by using either photometric transit or radial-velocity (RV) techniques. In the latter case the gain is twofold because the signal induced by the…
Melissa Lee, Ariana Cosic, Kurt Tobler, Claudio Aguilar + 2 more
Rotaviruses (RV) are classified into nine species, A-C and D-J, with species A being the most studied. In rotavirus of species A (RVA), replication occurs in viroplasms, which are cytosolic globular inclusions primarily composed of the proteins NSP5, NSP2, and VP2. The co-expression of NSP5 with either NSP2 or VP2…
Ariana Cosic, Melissa Lee, Kurt Tobler, Claudio Aguilar + 2 more
Rotavirus (RV) is classified into nine species, A-D and F-J, with RV species A (RVA) being the most extensively studied. While RVA infects infants and young animals, non-RVA species infect adult humans, various mammals, and birds. However, the lack of appropriate research tools has limited our understanding of non-RVA…
julio coll
Despite the abundant diseases caused by rhabdoviruses on plants, animals and men, there are no approved therapeutic drugs. This work targeted viral hemorrhagic septicemia viruses (VHSV), a group of representative rhabdoviruses causing devastating world-wide diseases on fish farmed-species. In particular, their…
Gautam Siddharth Kashyap, Alexander E. I. Brownlee, Orchid Chetia Phukan, Karan Malik + 1 more
'Orchid Chetia Phukan' 'Karan Malik' 'Samar Wazir'] Abstract— The well-known Vehicle Routing Problem with Time Windows (VRPTW) aims to reduce the cost of moving goods between several destinations while accommodating constraints like set time windows for certain locations and vehicle capacity. Applications of the VRPTW…