25 papers · ranked by Valyu relevance
David C. Krakauer, Lydia Müller, Sonja J. Prohaska, Peter F. Stadler
A critical feature of all cellular processes is the ability to control the rate of gene or protein expression and metabolic flux in changing environments through regulatory feedback. We review the many ways that regulation is represented through causal, logical and dynamical components. Formalizing the nature of these…
Vicky Chuqiao Yang, Christopher P. Kempes, Sidney Redner, G.B. West + 1 more
'Hyejin Youn'] Regulatory functions are essential in both socioeconomic and biological systems, from corporate managers to regulatory genes in genomes. Regulatory functions come with substantial costs, but are often taken for granted. Here, we empirically examine regulatory costs across diverse systems—biological…
Fotios Fitsilis
It is my very real pleasure to have the opportunity to write the foreword to this important new book by Dr. Fotios Fitsilis. The focus of his work is on how to regulate advanced algorithms, where the emergence of new technologies continues to present challenges for, among other things, science, law, and politics. For…
A Kaushik, KS Saini, B Anil, S Rambabu
Medical device sector is one of the most complex and challenging business segments of the healthcare industry with close collaboration between science and engineering. Despite the fact that Asia has 60% of the world population providing large market potential, Asian healthcare expenditure constitutes only 15% of the…
Rachel Horne, Tom Putland, Mark Brady
Australia is a leader in autonomous systems technology, particularly in the mining industry, borne from necessity in a geographically dispersed and complex natural environment. Increasingly advanced autonomous systems are becoming more prevalent in Australia, particularly as the safety, environmental and efficiency…
Jinah Yoon, Sukhyang Lee, Min Jung Kim, Jung-Hyun Kim
The rapid advancements in regenerative medicine (RM), including cell therapies, gene therapies, tissue-engineered products, and combined RM advanced therapies, require the development of regulatory frameworks. The global landscape of regulatory frameworks presents diverse approaches to the oversight of these therapies…
Selim Kalayci, Myvizhi Esai Selvan, Irene Ramos, Chris Cotsapas + 6 more
Humans can vary considerably in their healthy immune phenotypes and in their immune responses to various stimuli. We have developed an interactive web-based tool, ImmuneRegulation, to enable discovery of human regulatory elements that drive some of the phenotypic differences observed in gene expression profiles.…
Ron Teichner, Aseel Shomar, O. Barak, N. Brenner + 3 more
Homeostasis, the ability to maintain a relatively constant internal environment in the face of perturbations, is a hallmark of biological systems. It is believed that this constancy is achieved through multiple internal regulation and control processes. Given observations of a system, or even a detailed model of one…
Lisa Eckstein, Jenny C. Kaldor, Cameron Stewart
In Australia, Human Research Ethics Committees (HRECs) play a ubiquitous role reviewing human subjects research, as do Institutional Review Boards in the US and elsewhere. While HRECs were established as peer review bodies, we argue they should now be characterised a ‘devolved regulator’ within the broader context of…
Anuja R. Shah, R. K. Goyal
In the light of escalating use of medical devices, stringent regulatory standards are required to ensure that the devices are safe, well studied and have least adverse reactions. Recently introduced guidelines and the amendment in the law will provide adequate guidance for both the manufacturers and competent…
Peter Grossi, Daphne O’Connor
Over the past 25 years, Congress and the FDA have determined the safest and most beneficial way to regulate the use of mifepristone (Mifeprex), the medication that accounts for the majority of abortions in the United States. The Dobbs decision has renewed the importance of those scientific determinations, especially…
Iraj Daizadeh
Is the complexity of medical product (medicines and medical devices) regulation impacting innovation in the US? If so, how? Here, this question is investigated as follows: Various novel proxy metrics of regulation (FDA-issued guidelines) and innovation (corresponding FDA-registrations) from 1976-2020 are used to…
Petra Maresova
Economic regulation is an instrument of the state or other institutions to correct market failures, rectify the business environment, or protect consumers. Regulation can be a major driver of innovation, and it has proven to be so in the past. On the other hand, there are also documented cases of ineffective regulation…
Bolun Xu, Yury Dvorkin, Daniel S. Kirschen, Cesar A. Silva-Monroy + 1 more
'Jean‐Paul Watson'] Abstract—Because energy storage systems have better ramping characteristics than traditional generators, their participation in frequency regulation should facilitate the balancing of load and generation. However, they cannot sustain their output indefinitely. System operators have therefore…
Authors not listed
We use coarse-grained simulations to study the impact of charge regulation on the complexation of a weak polyacid and a strong polycation. Comparing an isolated polyacid with the polyelectrolyte pair, we demonstrate that charge regulation leads to a significant enhancement of the ionization. Furthermore, our…
Authors not listed
Molecular mechanisms governing initiation steps of the assembly of thousands of endogenous multi-protein complexes (EMCs) remain incompletely understood. Here, multiple lines of observations are reported reflecting the biological functions-aligned initiation sequence of hybrid assembly pathways (HAPs) of EMCs. HAPs…
Sanmoy Pathak, Thea Hogan, Sanket Rane, Yundi Huang + 5 more
Foxp3^+^ Regulatory T cells (Treg) are a subset of CD4^+^ T cells that play critical functions in maintaining tolerance to self antigens and suppressing autoimmunity, regulating immune responses to pathogens and have a role in the pathophysiology of anti-tumoural immunity. Treg ontogeny is complex since they are…
Authors not listed
A framework for catalysis based on categorical aperture selection rather than temporal acceleration is presented. Traditional catalysis theory describes catalysts as agents that accelerate reactions by lowering activation energies, implicitly treating time as the fundamental variable and reaction rate enhancement as…
David S. Lucas, Christopher Boudreaux
Regulation is commonly viewed as a hindrance to entrepreneurship, but heterogeneity in the effects of regulation is rarely explored. We focus on regional variation in the effects of national-level regulations by developing a theory of hierarchical institutional interdependence. Using the political science theory of…
Marie Goepp, Siobhan Crittenden, You Zhou, Adriano G Rossi + 2 more
Regulatory T (Treg) cells are essential for control of inflammatory processes by suppressing Th1 and Th17 cells. The bioactive lipid mediator prostaglandin E_2_ (PGE_2_) promotes inflammatory Th1 and Th17 cells and exacerbates T cell-mediated autoimmune diseases. However, the actions of PGE_2_ on the development and…
BB Thukral
No civilization…would ever have been possible without a framework of stability, to provide the wherein for the flux of change. Foremost among the stabilizing factors, more enduring than customs, manners, and traditions, are the legal systems that regulate our life in the world and our daily affairs with each other. -…
Huiyun Lv, Guohua Yuan, Xinyi Liu, Xiaobo Wang + 6 more
Thymus-originated tTregs and in vitro induced iTregs are subsets of regulatory T cells. While they share the capacity of immune suppression, their stabilities are different, with iTregs losing their phenotype upon stimulation or under inflammatory milieu. Epigenetic differences, particularly methylation state of Foxp3…
Thiago Escobar Colla, Amin Bakhshandeh, Yan Levin
We explore charge regulation (CR) of spherical nanoparticles immersed in an asymmetric electrolyte of a specified pH. Using a recently developed reactive canonical Monte Carlo (MC) simulation method, titration isotherms are obtained for suspensions containing monovalent, divalent, and trivalent coions. A theory based…
Junwen Zhu, Yongkang Hao, Fenghua Zhang, Xiaxia Gao + 3 more
In mammals, regulatory T cells (Treg) cells have been utilized to enhance tolerance in organ transplantation. Although transplanting germline stem cells (GSCs) or gonadal primordia into immunodeficient zebrafish have shown to be an important technique which can bypass the juvenile phase and expedite gamete generation…
Janet Sasso, Barbara Ambrose, Rumiana Tenchov, Ruchira Datta + 3 more
In the last decade, there has been a shift in research, clinical development, and commercial activity to exploit the many roles of RNA in physiology for use in medicine. With the rapid success in the development of lipid-RNA nanoparticles for mRNA vaccines against COVID-19 and with several approved RNA-based drugs, RNA…