18 papers · ranked by Valyu relevance
Kaylee M. Odum, Rishikesh K. Gupta, Elysia A. Gauthier, Alexander J. Fisch + 3 more
The precise development of the visual system is driven by retinal waves, which are bursts of spontaneous activity that propagate across retinal neurons in a wave-like fashion. In mice, retinal waves begin embryonically and continue until eye opening at the end of the second postnatal week. During this time, the…
Kaylee M. Yeager, Rishikesh K. Gupta, Elysia A. Gauthier, Alexander J. Fisch + 3 more
The precise development of the visual system is driven by retinal waves, which are bursts of spontaneous activity that propagate across retinal neurons in a wave-like fashion. In mice, retinal waves begin embryonically and continue until eye opening at the end of the second postnatal week. During this time, the…
David A. Arroyo, Marla B. Feller
Coordinated spontaneous activity is present in different sensory systems during early stages of development. This activity is thought to play a critical role in the development of sensory representations before the maturation of sensory experience. In the visual system, the mechanisms by which spatiotemporal properties…
Daniel Kerschensteiner
Spontaneous activity patterns propagate through many parts of the developing nervous system and shape the wiring of emerging circuits. Prior to vision, waves of activity originating in the retina propagate through the lateral geniculate nucleus (LGN) of the thalamus to primary visual cortex (V1). Retinal waves have…
Christiane Voufo, Andy Quaen Chen, Benjamin E. Smith, Marla B. Feller + 1 more
Spontaneous activity is a hallmark of developing neural systems. In the retina, spontaneous activity comes in the form of retinal waves, comprised of three stages persisting from embryonic day 16 (E16) to eye opening at postnatal day 14 (P14). Though postnatal retinal waves have been well characterized, little is known…
Christiane Voufo, Andy Quaen Chen, Benjamin E Smith, Rongshan Yan + 4 more
'Marla B Feller' 'Alexandre Tiriac' 'Fred Rieke' 'Marianne E Bronner'] Spontaneous activity is a hallmark of developing neural systems. In the retina, spontaneous activity comes in the form of retinal waves, comprised of three stages persisting from embryonic day 16 (E16) to eye opening at postnatal day 14 (P14).…
Bruno Cessac
We investigate the dynamics of stage II retinal waves via a dynamical system, grounded on biophysics, and analysed with bifurcation theory. We show how the nonlinear cells coupling and bifurcation structure explain how waves start, propagate, interact and stop. Especially, we analyse how the existence of a small region…
Dora Matzakos-Karvouniari, Bruno Cessac, Lionel Gil
Based on a biophysical model of retinal Starburst Amacrine Cell (SAC) [1] we analyse here the dynamics of retinal waves, arising during the visual system development. Waves are induced by spontaneous bursting of SACs and their coupling via acetycholine. We show that, despite the acetylcholine coupling intensity has…
Kathy Zhang, Ashley Su, Yixiang Wang, Michael Crair
Spontaneous retinal waves are a critical driving force for the self-organization of the mouse visual system prior to eye-opening. Classically characterized as taking place in three distinct stages defined by their primary excitatory drive, Stage II waves during the first postnatal week are propagated through the volume…
Benjamin Lansdell, Kevin Ford, J. Nathan Kutz
Prior to receiving visual stimuli, spontaneous, correlated activity in the retina, called retinal waves, drives activity-dependent developmental programs. Early-stage waves mediated by acetylcholine (ACh) manifest as slow, spreading bursts of action potentials. They are believed to be initiated by the spontaneous…
Benjamin Cappell, Andreas Stoll, Williams Chukwudi Umah, Bernhard Egger
'Bernhard Egger'] Computational models trained on a large amount of natural images are the stateof-the-art to study human vision – usually adult vision. Computational models of infant vision and its further development are gaining more and more attention in the community. In this work we aim at the very beginning of…
Jinwoo Kim, Min Song, Se-Bum Paik
In the primary visual cortex (V1) of higher mammals, long-range horizontal connections (LHCs) are observed to develop, linking iso-orientation domains of cortical tuning. It is unknown how this feature-specific wiring of circuitry develops before eye opening. Here, we show that LHCs in V1 may originate from…
Lilly May, Alice Dauphin, Julijana Gjorgjieva
The ability to process visual stimuli rich with motion represents an essential skill for animal survival and is largely already present at the onset of vision. Although the exact mechanisms underlying its maturation remain elusive, spontaneous activity patterns in the retina, known as retinal waves, have been shown to…
Kara G. Pratt, Masaki Hiramoto, Hollis T. Cline
Neural circuit development is an activity-dependent process. This activity can be spontaneous, such as the retinal waves that course across the mammalian embryonic retina, or it can be sensory-driven, such as the activation of retinal ganglion cells (RGCs) by visual stimuli. Whichever the source, neural activity…
Jennifer Crodelle, Wei P. Dai
Spontaneous waves are ubiquitous during early brain development and are hypothesized to drive the development of receptive fields (RFs). Different stages of spontaneous waves in the retina have been observed to coincide with the development of the retinotopic map, ON-OFF segregation, and orientation selectivity in the…
Leo M Chalupa
In all mammalian species the projections of the two eyes to the dorsal lateral geniculate nucleus are initially overlapping before gradually forming the eye-specific domains evident at maturity. It is widely thought that retinal waves of neuronal activity play an instructional role in this developmental process. Here…
Francesco Talotta, David Lauvergnat, Federica Agostini
The exact factorization of the electron-nuclear wavefunction is applied to the study of the photo- isomerization of a retinal chromophore model. We describe such an ultrafast nonadiabatic process by analyzing the time-dependent potentials of the theory and by mimicking nuclear dynamics with quantum and coupled…
Konstantin Komarov, Woojin Park, Seunghoon Lee, Miquel Huix-Rotllant + 1 more
It is demonstrated that significant accuracy improvements of MRSF-TDDFT can be achieved by introducing two different XC functionals for the reference Kohn-Sham DFT and the response part of calculations, respectively. Accordingly, two new exchange-correlation (XC) functionals of DTCAM-VEE and DTCAM-AEE were developed on…