28 papers · ranked by Valyu relevance
Bram L. Gorissen, İhsan Yanıkoğlu, Dick den Hertog
Robust optimization is a young and active research field that has been mainly developed in the last 15 years. Robust optimization is very useful for practice, since it is tailored to the information at hand, and it leads to computationally tractable formulations. It is therefore remarkable that real-life applications…
Matteo Aldeghi, Florian Häse, Riley J. Hickman, Isaac Tamblyn + 1 more
Numerous challenges in science and engineering can be framed as optimization tasks, including the maximization of reaction yields, the optimization of molecular and materials properties, and the fine-tuning of automated hardware protocols. Design of experiment and optimization algorithms are often adopted to solve…
Aharon Ben‐Tal, Elad Hazan, Tomer Koren, Shie Mannor
Robust optimization is a common framework in optimization under uncertainty when the problem parameters are not known, but it is rather known that the parameters belong to some given uncertainty set. In the robust optimization framework the problem solved is a min-max problem where a solution is judged according to its…
Juan Feller, Alejandro F. Mac Cawley, Jorge A. Ramos-Grez, Iván La Fé-Perdomo + 1 more
'Iván La Fé-Perdomo' 'Yogendra Arya'] The acquisition of Advanced Manufacturing Technologies (AMT), such as high-power fiber or CO2 laser cutting equipment, generally involves high investment levels. Its payback period is usually more extended, and there is a moderate-to-high risk involved in adopting these…
Éva Kenyeres, Alex Kummer, János Abonyi
This paper introduces a methodology for handling different types of uncertainties during robust optimization. In real-world industrial optimization problems, many types of uncertainties emerge, e.g., inaccurate setting of control variables, and the parameters of the system model are usually not known precisely. For…
Zhu, Karl, Dimitris Bertsimas
Adaptive robust optimization (ARO) extends static robust optimization by allowing decisions to depend on the realized uncertainty — weakly dominating static solutions within the modeled uncertainty set. However, ARO makes previous constraints that were independent of uncertainty now dependent, making it vulnerable to…
Qing-chun Meng, Xiao-le Wan, Xiao-xia Rong, Yongtang Shi
Free shipping with conditions has become one of the most effective marketing tools available. An increasing number of companies, especially e-businesses, prefer to offer free shipping with some predetermined condition, such as a minimum purchase amount by the customer. However, in practice, the demands of buyers are…
Irina Wang, Cole Becker, Bart Van Parys, Bartolomeo Stellato
Robust optimization is a tractable and expressive technique for decision-making under uncertainty, but it can lead to overly conservative decisions when pessimistic assumptions are made on the uncertain parameters. Wasserstein distributionally robust optimization can reduce conservatism by being data-driven, but it…
Richa Verma, Dinesh Kumar, Kazuma Kobayashi, Syed Bahauddin Alam
Robust optimization is a method for optimization under uncertainties in engineering systems and designs for applications ranging from aeronautics to nuclear. In a robust design process, parameter variability (or uncertainty) is incorporated into the engineering systems' optimization process to assure the systems'…
Parthasarathi Mondal, Akshay Kumar Ojha
Robust optimization(RO) is an important tool for handling optimization problem with uncertainty. The main objective of RO is to solve optimization problems due to uncertainty associated with constraints satisfying all realizations of uncertain values within a given uncertainty set. The challenge of RO is to reformulate…
Lei Wang, Min Fang
In this paper, we consider the multiobjective linear programs where coefficients in the objective function belong to uncertainty sets. We introduce the concept of robust efficient solutions to uncertain multiobjective linear programming problems. By using two scalarization methods, the weighted sum method and the…
Ruth Misener, Mark C. Allenby, María Fuentes‐Garí, Karan Gupta + 4 more
'Thomas Wiggins' 'Nicki Panoskaltsis' 'Efstratios N. Pistikopoulos' 'Athanasios Mantalaris'] As breakthrough cellular therapy discoveries are translated into reliable, commercializable applications, effective stem cell biomanufacturing requires systematically developing and optimizing bioprocess design and operation.…
Fabian Chlumsky-Harttmann, Marie Schmidt, Anita Schöbel
Real-world optimization problems often do not just involve multiple objectives but also uncertain parameters. In this case, the goal is to find Pareto-optimal solutions that are robust, i.e., reasonably good under all possible realizations of the uncertain data. Such solutions have been studied in many papers within…
Marc Goerigk, Anita Schöbel
Robust optimization is a young and emerging field of research having received a considerable increase of interest over the last decade. In this paper, we argue that the the algorithm engineering methodology fits very well to the field of robust optimization and yields a rewarding new perspective on both the current…
Nathan C. L. Kong, Eshed Margalit, Justin L. Gardner, Anthony M. Norcia
Task-optimized convolutional neural networks (CNNs) show striking similarities to the ventral visual stream. However, human-imperceptible image perturbations can cause a CNN to make incorrect predictions. Here we provide insight into this brittleness by investigating the representations of models that are either robust…
Ziwei Chen, Bingwei Zhang, Fuzhou Gong, Lin Wan + 1 more
Robust Principal Component Analysis (RPCA) offers a powerful tool for recovering a low-rank matrix from highly corrupted data, with growing applications in computational biology. Biological processes commonly form intrinsic hierarchical structures, such as tree structures of cell development trajectories and tumor…
Authors not listed
Continuous manufacturing processes offer significant advantages over batch processes, including easier scalability, reduced costs, lower raw material and solvent consumption, and improved energy efficiency. A robust techno-economic assessment is therefore essential to evaluate and facilitate the adoption of such…
Eric Hermes, Khachik Sargsyan, Habib Najm, Judit Zádor
We present a new algorithm for the optimization of molecular structures to saddle points on the potential energy surface using a redundant internal coordinate system. This algorithm automates the procedure of defining the internal coordinate system, including the handling of linear bending angles, e.g. through the…
Authors not listed
Self-driving laboratories (SDLs) have the potential to revolutionize chemical discovery and optimization, yet their widespread adoption remains limited by high costs, complex infrastructure, and limited accessibility. Here, we introduce RoboChem-Flex, a low-cost, modular self-driving laboratory platform designed to…
Fabian Fröhlich, Peter K. Sorger
Ordinary differential equation (ODE) models are widely used to describe biochemical processes, since they effectively represent mass action kinetics. Optimization-based calibration of ODE models on experimental data can be challenging, even for low-dimensional problems. However, reliable model calibration is a…
Vahid Mardanlou, Elisa Franco
In a synthetic biological network it may often be desirable to maximize or minimize parameters such as reaction rates, fluxes and total concentrations of reagents, while preserving a given dynamic behavior. We consider the problem of parameter optimization in biomolecular bistable circuits. We show that, under some…
Mae Woods, Miriam Leon, Ruben Perez-Carrasco, Chris P. Barnes
The engineering of transcriptional networks presents many challenges due to the inherent uncertainty in the system structure, changing cellular context and stochasticity in the governing dynamics. One approach to address these problems is to design and build systems that can function across a range of conditions; that…
Hua-Dong Xiong, Li Ji-An, Marcelo G. Mattar, Robert C. Wilson
Cognitive modeling provides a formal method to articulate and test hypotheses about cognitive processes. However, accurately and reliably estimating model parameters remains challenging due to common issues in behavioral science, such as limited data, measurement noise, experimental constraints, and model complexity.…
Riley Hickman, Priyansh Parakh, Austin Cheng, Qianxiang Ai + 3 more
Experiment planning algorithms are a required component of autonomous platforms for scientific discovery. Selecting a suitable optimization algorithm for a novel application is an important yet difficult choice a researcher has to make based on past empirical performance on similar tasks. To facilitate the evaluation…
Thomas T. Liu, Bochao Li, Brice Fernandez, Suchandrima Banerjee
In multi-echo fMRI (ME-fMRI), two metrics have been widely used to measure the performance of various acquisition and analysis approaches. These are temporal SNR (tSNR) and differential contrast-to-noise ratio (dCNR). A key step in ME-fMRI is the weighted combination of the data from multiple echoes, and prior work has…
Authors not listed
Solving optimization problems, especially for nonlinear and constrained systems, is a challenge. Decades of specialized algorithms have been developed for general and special cases of root finding, minimization (including constraints), for parameter estimation, and mapping connected spaces. These approaches typically…
Authors not listed
Optimizing the synthesis conditions of advanced materials is challenging, especially when outcomes are subject to inherent experimental uncertainties. Bayesian optimization is a popular tool for accelerating materials discovery, but its standard risk-neutral framework overlooks the variability of outcomes under…
Sterling Baird, Jason R. Hall, Taylor D. Sparks
Would you rather search for a line inside a cube or a point inside a square? Physics-based simulations and wet-lab experiments often have symmetries (degeneracies) that allow reducing problem dimensionality or search space, but constraining these degeneracies is often unsupported or difficult to implement in many…