13 papers · ranked by Valyu relevance
Abdelrahman Kaseb, Mona Farouk
Sentiment analysis becomes an essential part of every social network, as it enables decisionmakers to know more about users' opinions in almost all life aspects. Despite its importance, there are multiple issues it encounters like the sentiment of the sarcastic text which is one of the main challenges of sentiment…
Julie Krainer, Sandra Siebenhandl, Andreas Weinhäusel
Systemic autoinflammatory diseases (SAIDs) are a growing group of disorders caused by a dysregulation of the innate immune system leading to episodes of systemic inflammation. In 1997, MEFV was the first gene identified as disease causing for Familial Mediterranean Fever, the most common hereditary SAID. In most cases…
Yichao Hua, Na Wu, Junke Miao, Min Shen
Systemic autoinflammatory diseases (SAIDs) are a group of rare diseases characterized by recurrent or continuous inflammation, typically accompanied by genetic variants. Good responses to anti-TNFα therapy were observed in SAIDs patients. However, the mechanisms underlying the disease flare and the response to TNFα…
Willem Maassen, Geertje Legger, Ovgu Kul Cinar, Paul van Daele + 17 more
Introduction Accurate and standardized phenotypic descriptions are essential in diagnosing rare diseases and discovering new diseases, and the Human Phenotype Ontology (HPO) system was developed to provide a rich collection of hierarchical phenotypic descriptions. However, although the HPO terms for inborn errors of…
Kátia Tomie Kozu, Renan Rodrigues Neves Ribeiro do Nascimento, Patrícia Pontes Aires, Rafael Alves Cordeiro + 5 more
Systemic autoinflammatory diseases (SAIDs) arise from dysregulated innate immune system activity, which leads to systemic inflammation. These disorders, encompassing a diverse array of genetic defects classified as inborn errors of immunity, are significant diagnostic challenges due to their genetic heterogeneity and…
Curtis W. Noonan, Jean C. Pfau, Theodore C. Larson, Michael R. Spence
Population Authors: ['Curtis W. Noonan' 'Jean C. Pfau' 'Theodore C. Larson' 'Michael R. Spence'] Objective To explore the potential association between asbestos exposure and risk of autoimmune disease, we conducted a case-control study among a cohort of 7,307 current and former residents of Libby, Montana, a community…
Yichao Hua, Na Wu, Junke Miao, Min Shen
Systemic autoinflammatory diseases (SAIDs) are a group of rare diseases characterized by recurrent or continuous inflammation, typically accompanied by genetic variants. Good responses to anti-TNF therapy were observed in SAIDs patients. However, the mechanisms underlying the disease flare and the response to TNF…
M Rusmini, S Federici, F Caroli, A Grossi + 13 more
'A Insalaco' 'A Tommasini' 'R Caorsi' 'E Gallo' 'AN Olivieri' 'AV Marzano' 'D Coviello' 'R Ravazzolo' 'A Martini' 'M Gattorno' 'I Ceccherini'] Introduction Systemic autoinflammatory diseases (SAIDs) are a group of monogenic disorders characterized by inflammation which occurs in the absence of pathogenic…
Authors not listed
Native mass spectrometry (nMS) is increasingly popular for studying intact protein quaternary structure. When coupled with ion mobility, which separates ions based on their size, charge, and shape, it provides additional structural information on the protein complex of interest. In this study, we present a novel…
Rafael Veiga, Leana De Vuyst, Christophe Poulet, Julika Neumann + 15 more
Autoinflammation of unknown origin remains amongst the most enigmatic of systemic autoinflammatory disorders (SAIDs), immunological disorders characterized by inappropriate activation of the innate immune response. Recent clinical research has identified multiple distinct disorders, although overlap in clinical…
Amanda Clarke, Caitlin McDowell, Paul Badcock
Systemic autoinflammatory disorders (SAID), immune dysregulation disorders with onset frequently occurring in youth, are defined by unprovoked inflammation. Research suggest inflammation is associated with the pathogenesis of mental ill-health. Separately, research has identified that mental ill-health is prevalent in…
Rafael Veiga, Leana De Vuyst, Julika Neumann, Leoni Bücken + 7 more
Autoinflammation of unknown origin remains amongst the most enigmatic of systemic autoinflammatory disorders (SAIDs), immunological disorders characterized by inappropriate activation of the innate immune response. Recent clinical research has identified multiple distinct disorders, although overlap in clinical…
Yandie Li, Meiping Yu, Meiping Lu
Background Systemic autoinflammatory diseases (SAIDs) are hyperinflammatory and immune-dysregulation conditions that present in childhood. This kind of disease is a rare disease with early-onset, severe condition and difficult diagnosis, which seriously affects the growth and development of children. Most children need…