24 papers · ranked by Valyu relevance
Jessica Y. Hsu, Etienne P. Danis, Stephanie Nance, Jenean O’Brien + 10 more
Rhabdomyosarcoma (RMS) is a pediatric skeletal muscle sarcoma characterized by the expression of the myogenic-lineage transcription factors (TF) MYOD1 and MYOG. Despite high expression of these TFs, RMS cells fail to terminally differentiate, suggesting the presence of factors that alter their function. Here, we…
Kelsey Coppenrath, Andre L.P. Tavares, Nikko-Ideen Shaidani, Marcin Wlizla + 2 more
The vertebrate Six (Sine oculis homeobox) family of homeodomain transcription factors play critical roles in the development of several organs. Six1 plays a central role in cranial placode development, including the precursor tissues of the inner ear, as well as other cranial sensory organs and the kidney. In humans…
Songyuan Luo, Zhixu Liu, Qian Bian, Xudong Wang
Craniofacial development requires intricate cooperation between multiple transcription factors and signaling pathways. Six1 is a critical transcription factor regulating craniofacial development. However, the exact function of Six1 during craniofacial development remains elusive. In this study, we investigated the role…
Shanshan Huang, Wanling Lin, Lei Wang, Yuan Gao + 4 more
'Peng Zhang' 'Yuan Chen' 'Qian Chu'] Background: Many transcription factors involved in embryonic development and reactivated in tumors are considered potential prognostic biomarkers and novel therapeutic targets in various cancers. Sine oculis homeobox homolog 1 (SIX1), a developmentally restricted transcriptional…
Jumpei Terakawa, Vanida A. Serna, Devi Nair, Shigeru Sato + 4 more
During female mammal reproductive tract development, epithelial cells of the lower Müllerian duct are committed to become stratified squamous epithelium of vagina and ectocervix, when the expression of ΔNp63 transcription factor is induced by mesenchymal cells. The absence of ΔNp63 expression leads to adenosis, the…
Hongming Wang, Weishuang Xue, Wunyu Ouyang, Xiaoze Jiang + 1 more
'Xuejun Jiang'] SIX1 overexpression has been reported in several cancers. However, its involvement in head and neck squamous cell carcinoma (HNSCC) remains unclear. In this study we investigated the clinical significance and biological roles of SIX1 in HNSCC. SIX1 expression was upregulated in HNSCC and correlated with…
Ricardo D Coletta, Erica L McCoy, Valerie Burns, Kiyoshi Kawakami + 3 more
'James L McManaman' 'John J Wysolmerski' 'Heide L Ford'] Background The Six1 homeobox gene is highly expressed in the embryonic mammary gland, continues to be expressed in early postnatal mammary development, but is lost when the mammary gland differentiates during pregnancy. However, Six1 is re-expressed in breast…
Somin Lee, Yejin Yun, Ju Hyuen Cha, Jin Hee Han + 7 more
'Jae-Jin Song' 'Moo Kyun Park' 'Jun Ho Lee' 'Seung Ha Oh' 'Byung Yoon Choi' 'Sang-Yeon Lee'] Branchio-oto-renal (BOR)/branchio-otic (BO) syndrome is a rare disorder and exhibits clinically heterogenous phenotypes, marked by abnormalities in the ear, branchial arch, and renal system. Sporadic cases of atypical BOR/BO…
Yong Jin, Manling Zhang, Meishuang Li, Hong Zhang + 9 more
'Cheng Qian' 'Shensen Li' 'Hao Zhang' 'Min Gao' 'Binbin Pan' 'Rongfeng Li' 'Xin Wan' 'Changchun Cao'] Nephrogenic proteins are re-expressed after ischemia/reperfusion (I/R) injury; however, the role of these proteins is still unknown. We found that sine oculis homeobox 1 (SIX1), a developmentally regulated…
K T Ng, K Man, C K Sun, T K Lee + 3 more
Tumour recurrence and metastases of hepatocellular carcinoma (HCC) after hepatectomy are the major obstacles of long-term survival. The present study investigated the clinicopathological significance of a possible metastasis regulator Six1 in HCC patients who were undergone hepatectomy. Seventy-two pairs of RNA and 103…
Nancy Wareing, Tingting W Mills, Scott Collum, Minghua Wu + 13 more
Dermal fibrosis is a cardinal feature of systemic sclerosis (SSc) for which there are limited treatment strategies. This is in part due to our fragmented understanding of how dermal white adipose tissue (DWAT) contributes to skin fibrosis. We identified elevated sine oculis homeobox homolog 1 (SIX1) expression in SSc…
Matthew J. Stevenson, Sabrina K. Phanor, Urvi Patel, Stephen S. Gisselbrecht + 2 more
Wilms tumors present as an amalgam of varying proportions of three tissues normally located within the developing kidney, one being the multipotent nephron progenitor population. While incomplete differentiation of the nephron progenitors is widely-considered the underlying cause of tumor formation, where this barrier…
Minky Seo, Hyung Kook Choi, S.-Y. Lee, N. Kim + 4 more
'H.-S. Sim' 'V. Umansky' 'D. Mahalu'] We experimentally investigate the charge (isospin) frustration induced by a geometrical symmetry in a triangular triple quantum dot. We observe the ground-state charge configurations of six-fold degeneracy, the manifestation of the frustration. The frustration results in…
N. L. Harshman
Energy level splitting from the unitary limit of contact interactions to the near unitary limit for a few identical atoms in an effectively one-dimensional well can be understood as an example of symmetry breaking. At the unitary limit in addition to particle permutation symmetry there is a larger symmetry…
Erik Nielsen, Edwin Barnes, J. P. Kestner, S. Das Sarma
We consider a double-quantum-dot (DQD) qubit which contains six electrons instead of the usual one or two. In this spin qubit, quantum information is encoded in a low-lying singlet-triplet space much as in the case of a two-electron DQD qubit. We find that initialization, manipulation, and readout can be performed…
Ayaki Sunaga
The structures and some vertical excitation energies of third-row transition metal hexafluorides (MF6, M = Re, Os, Ir, Pt, Au, Hg) were calculated using the multi-reference configuration interaction (MRCI) theory based on exact two-component (X2C) Hamiltonian. The spin-orbit coupling (SOC) was variationally included at…
S. D. Liles, Ruoyu Li, Chih Hwan Yang, Fay E. Hudson + 3 more
'Menno Veldhorst' 'Andrew S. Dzurak' 'A. R. Hamilton'] The spin states of electrons confined in semiconductor quantum dots form a promising platform for quantum computation 1–3 . Recent studies of silicon CMOS qubits have shown coherent manipulation of electron spin states with extremely high fidelity 4 . However…
M. Ghazvini, Nasrin Salehi, A. A. Rajabi
In this paper, the Schrödinger equation for 6-body system is studied. We solved this equation for lithium nucleus by using supersymmetry method with the specific potentials. These potentials are Yukawa potential, the generalized Yukawa potential and Hellmann potential. The results of our model for all calculations show…
Todd Poe, Harry Ramanantoanina, Joseph Sperling, Hannah Wineinger + 9 more
Californium (Z = 98) is the first member of the actinide series displaying metastability of the 2+ oxidation state. Understanding the origin of this chemical behavior requires characterizing Cf(II) materials, but isolating a complex with this state has remained elusive. The source of its inaccessibility arises from the…
Authors not listed
Graphite is the anode material in the vast majority of current commercial lithium-ion batteries (LIBs) due to its excellent electrochemical performance and abundant reserves. However, the development of high-performance LIBs still faces technical bottlenecks including limited rate capability, partly because of the slow…
Wojciech Julian Pasek
The so called "incomplete hole shell filling" phenomenon, that is the breaking of the Aufbau principle was reported by D. Reuter et al., [Phys. Rev. Lett. 94, 026808] in the hole charging spectra of quantum dot when results were interpreted in context of s/p/d shell system – typical for electrons. We report an example…
Patrick O'Malley, Felix Rummel
In this report we combine broken symmetry density functional calculations and electron paramagnetic resonance analysis to obtain the electronic structure of the penultimate S3 state of Nature's water oxidising complex and determine the electronic pathway of O-O bond formation. Analysis of the electronic structure…
Anastasia Sorokina, Dmitry A. Rydnyk, Kirill Yu. Monakhov, Thomas Heine
One of the striking characteristics of the tris(alkoxo)-ligated Lindqvist-type polyoxovanadates [VV6O13{(OCH2)3CR}2]2– in highest oxidation state in solution is the ease of their chemical post-functionalization via the R group. On surfaces it is their conductivity as a function of individual V(3d) redox states. In both…
D. R. Nygren, B. J. P. Jones, N. López-March, Y. Mei + 2 more
'J. Renner'] Abstract: We present a new neutrinoless double beta decay concept: the high pressure selenium hexafluoride gas time projection chamber. A promising new detection technique is outlined which combines techniques pioneered in high pressure xenon gas, such as topological discrimination, with the high Q-value…