17 papers · ranked by Valyu relevance
Shanshan Huang, Wanling Lin, Lei Wang, Yuan Gao + 4 more
'Peng Zhang' 'Yuan Chen' 'Qian Chu'] Background: Many transcription factors involved in embryonic development and reactivated in tumors are considered potential prognostic biomarkers and novel therapeutic targets in various cancers. Sine oculis homeobox homolog 1 (SIX1), a developmentally restricted transcriptional…
Guang Zhu, Ying Liu, Lei Zhao, Zhenhua Lin + 1 more
Sine Oculis Homeobox Homolog 1 (SIX1) is reported to promote cancer initiation and progression in many preclinical models and is demonstrated in human cancer tissues. However, the correlation between SIX1 and cancer patients’ prognosis has not yet been systematically evaluated. Therefore, we performed a systematic…
Songyuan Luo, Zhixu Liu, Qian Bian, Xudong Wang
Craniofacial development requires intricate cooperation between multiple transcription factors and signaling pathways. Six1 is a critical transcription factor regulating craniofacial development. However, the exact function of Six1 during craniofacial development remains elusive. In this study, we investigated the role…
Pelin Balçık-Erçin, Arzu Aysan, Nazlı Salık, Esma Erciyas
Background/Aims: Sine oculis homeoprotein 1 exerts an essential role in embryonic development, and it was also identified to be reactivated in various types of mammalian cancer. The sine oculis homeoprotein 1 transcription factor was demonstrated to induce epithelial-mesenchymal transition, regulate crucial genes…
Connor J. Hughes, Kaiah M. Fields, Etienne P. Danis, Jessica Y. Hsu + 9 more
'Deepika Neelakantan' 'Melanie Y. Vincent' 'Annika L. Gustafson' 'Michael J. Oliphant' 'Varsha Sreekanth' 'Vadym Zaberezhnyy' 'James C. Costello' 'Paul Jedlicka' 'Heide L. Ford'] Ewing sarcoma (ES), which is characterized by the presence of oncogenic fusion proteins such as EWS/FLI1, is an aggressive pediatric…
Somin Lee, Yejin Yun, Ju Hyuen Cha, Jin Hee Han + 7 more
'Jae-Jin Song' 'Moo Kyun Park' 'Jun Ho Lee' 'Seung Ha Oh' 'Byung Yoon Choi' 'Sang-Yeon Lee'] Branchio-oto-renal (BOR)/branchio-otic (BO) syndrome is a rare disorder and exhibits clinically heterogenous phenotypes, marked by abnormalities in the ear, branchial arch, and renal system. Sporadic cases of atypical BOR/BO…
Nancy Wareing, Tingting W Mills, Scott Collum, Minghua Wu + 13 more
Dermal fibrosis is a cardinal feature of systemic sclerosis (SSc) for which there are limited treatment strategies. This is in part due to our fragmented understanding of how dermal white adipose tissue (DWAT) contributes to skin fibrosis. We identified elevated sine oculis homeobox homolog 1 (SIX1) expression in SSc…
Karyn Jourdeuil, Jasmina Gafurova, Ashley Ben-Mayor, Sally A. Moody + 1 more
Branchio-oto-renal (BOR) syndrome is an autosomal dominant condition characterized by variable craniofacial malformations, hearing loss and in some patients, renal dysfunction. Recently, a clinical study showed that patients with mutations causative of BOR also present with craniosynostosis, indicating that this could…
M Di Gallo, L Delivry, D Pereira, E Jauliac + 18 more
The different types of muscle fibres respond in a specific way to hypertrophy or atrophy. The mechanisms underlying these heterogeneous adaptations remain poorly understood. Using single-nucleus RNA sequencing, we propose that fast glycolytic fibres show genetic limitations to hypertrophy induced by mechanical…
Matthew J. Stevenson, Sabrina K. Phanor, Urvi Patel, Stephen S. Gisselbrecht + 2 more
Wilms tumors present as an amalgam of varying proportions of three tissues normally located within the developing kidney, one being the multipotent nephron progenitor population. While incomplete differentiation of the nephron progenitors is widely-considered the underlying cause of tumor formation, where this barrier…
Jeremy Rich, Melanie Bennaroch, Laura Notel, Polina Patalakh + 13 more
We have recently identified the uncharacterized ZNF555 protein as a component of a productive complex, which is involved in the morbid function of the 4qA locus in facioscapulohumeral dystrophy. As a result of our current findings, ZNF555 is hereinafter referred to as DiPRO1 (Death, Differentiation and PROliferation…
Ryan Roussel, Juan Pablo Gonzalez-Aguilera, Auralee Edelen, Eric Wisniewski + 4 more
measurements using generative machine learning Authors: ['Ryan Roussel' 'Juan Pablo Gonzalez-Aguilera' 'Auralee Edelen' 'Eric Wisniewski' 'Alex Ody' 'Wanming Liu' 'Y. K. Kim' 'John Power'] Next-generation accelerator concepts, which hinge on the precise shaping of beam distributions, demand equally precise diagnostic…
Shoki Sugimoto, Yuto Ashida, Masahito Ueda
A bound state in the continuum (BIC) is a spatially bounded energy eigenstate lying in a continuous spectrum of extended eigenstates. While various types of single-particle BICs have been found in the literature, whether or not BICs can exist in genuinely many-body systems remains inconclusive. Here, we provide…
Ablowitz, Mark J., Gupta, Ramesh + 4 more
The multi-dimensional six-wave interaction system is derived in the context of nonlinear optics. Starting from Maxwell's equations, a reduced system of equations governing the dynamics of the electric and polarization fields are obtained. Using a space-time multi-scale asymptotic expansion, a hierarchy of coupled…
Ayaki Sunaga
The structures and some vertical excitation energies of third-row transition metal hexafluorides (MF6, M = Re, Os, Ir, Pt, Au, Hg) were calculated using the multi-reference configuration interaction (MRCI) theory based on exact two-component (X2C) Hamiltonian. The spin-orbit coupling (SOC) was variationally included at…
Todd Poe, Harry Ramanantoanina, Joseph Sperling, Hannah Wineinger + 9 more
Californium (Z = 98) is the first member of the actinide series displaying metastability of the 2+ oxidation state. Understanding the origin of this chemical behavior requires characterizing Cf(II) materials, but isolating a complex with this state has remained elusive. The source of its inaccessibility arises from the…
Frederik Bopp, Jonathan Rojas, Natalia Revenga, Hubert Riedl + 12 more
'Friedrich Sbresny' 'Katarina Boos' 'Tobias Simmet' 'Arash Ahmadi' 'D. Gershoni' 'Jacek Kasprzak' 'Arne Ludwig' 'Stephan Reitzenstein' 'Andreas D. Wieck' 'D. Reuter' 'Kai M\x7fuller' 'Jonathan J. Finley'] Tunnel-coupled pairs of optically active quantum dots - quantum dot molecules (QDMs) - offer the possibility to…