5 papers · ranked by Valyu relevance
Vinicius Verri Hernandes, Benedikt Warth
Traditionally, chemical exposure has been assessed by low-resolution mass spectrometry via targeted approaches due to the typically extremely low concentration of such compounds in biological samples. Nevertheless, untargeted approaches are now becoming a promising tool for a broader investigation of the exposome…
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The Single-probe is a multifunctional device that can be coupled to mass spectrometry (MS) for molecular analysis of microscale samples, such as single cells, tissue slices, and multicellular spheroids, under ambient conditions. In Single-probe single cell MS (SCMS) studies, this technique leverages direct sampling and…
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Mass spectrometry (MS) generates large datasets that are stored in increasingly optimized and complex file types, demanding technical expertise to extract information rapidly and easily. We wondered whether a simple structured query language (SQL) database could hold raw MS data and allow for easily readable queries…
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The proper quantitative NMR (qNMR) setup requires efficient relaxation of all active nuclei between scans. To achieve this, the spectroscopist has to know the longitudinal relaxation constant (T1) for each nucleus involved in the experiment and set the interscan delay to at least five times the longest T1. The T1 is…
Damon Griffiths, Malcolm Anderson, Keith Richardson, Satomi Inaba-Inoue + 6 more
Hydrogen/deuterium exchange-mass spectrometry (HDX-MS) has emerged as a powerful tool to probe protein dynamics. As a bottom-up technique, HDX-MS provides information at peptide-level resolution, allowing structural localisation of dynamic changes. Consequently, HDX-MS data quality is largely determined by the number…