17 papers · ranked by Valyu relevance
Ziqiang Chen, Xiaobing Wang, Zelin Jin, Bosen Li + 22 more
Tertiary lymphoid structures (TLSs) have been associated with favorable immunotherapy responses and prognosis in various cancers. Despite their significance, their quantification using multiplex immunohistochemistry (mIHC) staining of T and B lymphocytes remains labor-intensive, limiting its clinical utility. To…
Lei Su, Ruiyu Li, Guangyao Zhang, Zonghao Liu + 6 more
This study focuses on tertiary lymphoid structure (TLS) semantic segmentation in whole slide images (WSIs). Unlike TLS binary segmentation, TLS semantic segmentation identifies boundaries and maturity and requires the integration of contextual information to discover discriminative features. Owing to the extensive…
Phil Wilkes, Mathias Disney, John Armston, Harm Bartholomeus + 14 more
Above Ground Biomass (AGB) is an important metric used to quantify the mass of carbon stored in terrestrial ecosystems. For forests, this is routinely estimated at the plot scale (typically ≥1 ha) using inventory measurements and allometry. In recent years, Terrestrial Laser Scanning (TLS) has appeared as a disruptive…
Lei Su, Yang Du
Structure Semantic Segmentation in Whole Slide Image Authors: ['Lei Su' 'Yang Du'] We focus on tertiary lymphoid structure (TLS) semantic segmentation in whole slide image (WSI). Unlike TLS binary segmentation, TLS semantic segmentation identifies boundaries and maturity, which requires integrating contextual…
Mart van Rijthoven, Simon Obahor, Fabio Pagliarulo, Maries van den Broek + 5 more
Tertiary lymphoid structures (TLSs) are dense accumulations of lym-phocytes in inflamed peripheral tissues, including cancer, and are associated with improved survival and response to immunotherapy in various solid tumors. Histological TLS quantification has been pro-posed as a novel predictive and prognostic…
Tianyi Gao, Xinshu Ma, Suhas Narreddy, Eugenio Luo + 2 more
'Steven W. D. Chien' 'Michio Honda'] Cloud applications need network data encryption to isolate from other tenants and protect their data from potential eavesdroppers in the network infrastructure. This paper presents SDP, a protocol design for emerging datacenter transport protocols, such as pHost, NDP, and Homa, to…
Yingying Cao, Michael Nirula, Paul Mallory, Sarthak Sahoo + 3 more
Tertiary lymphoid structures (TLS) are ectopic immune aggregates associated with improved prognosis and response to immunotherapy in multiple solid tumors. However, their presence, spatial organization, and functional relevance in small cell lung cancer (SCLC), a malignancy characterized by profound immune evasion…
Luis Munoz-Erazo, Saem Mul Park, Shelly Lin, Chun-Jen J. Chen + 7 more
Tertiary Lymphoid Structures (TLS) in cancer tissue are potential sites for the organisation of immune responses to cancer, and correlate positively with improved clinical outcomes for patients including in colorectal cancer (CRC). However it has proven challenging to standardise assessment of TLS due to the highly…
Shobiri, Behnam, Pourali, Sajjad + 10 more
—In many web applications, such as Content Delivery Networks (CDNs), TLS credentials are shared, e.g., between the website's TLS origin server and the CDN's edge servers, which can be distributed around the globe. To enhance the security and trust for TLS 1.3 in such scenarios, we propose LURK-T, a provably secure…
Henrique B. Brum, Matteo Franzil, Riccardo Germenia, Salvatore Manfredi + 2 more
Despite the widespread use of Transport Layer Security (TLS), its security guarantees are frequently compromised by outdated versions and misconfigurations. To analyze this problem, we collected more than 50 million TLS handshakes over a two-week period at our research institution, Fondazione Bruno Kessler, and…
Nikos Fotiou, Vasilios A. Siris, George C. Polyzos, Mario Marchese + 2 more
'Franco Davoli' 'Luca Boero'] Abstract—HTTPS enhances end-user privacy and is often preferred or enforced by over-the-top content providers, but renders inoperable all intermediate network functions operating above the transport layer, including caching, content/protocol optimization, and security filtering tools.…
Jhury Kevin Lastre, Yongho Ko, Hoseok Kwon, Ilsun You + 1 more
Cross-border Fifth Generation Mobile Communication (5G) roaming requires secure N32 connections between network operators via Security Edge Protection Proxy (SEPP) interfaces, but current Transport Layer Security (TLS) 1.3 implementations face a critical trade-off between connection latency and security guarantees.…
S.B. Girimurugan, Yuhang Liu, Pei-Yau Lung, Daniel L. Vera + 3 more
Identification of functional elements of a genome often requires dividing a sequence of measurements along a genome into segments where adjacent segments have different properties, such as different mean values. This problem is often called the segmentation problem in the field of genomics, and the change-point problem…
Manuel Suárez-Albela, Tiago M. Fernández-Caramés, Paula Fraga-Lamas, Luis Castedo
'Luis Castedo'] Fog computing extends cloud computing to the edge of a network enabling new Internet of Things (IoT) applications and services, which may involve critical data that require privacy and security. In an IoT fog computing system, three elements can be distinguished: IoT nodes that collect data, the cloud…
Koen Tange, Sebastian Mödersheim, Apostolos Lalos, Xenofon Fafoutis + 5 more
'Nicola Dragoni' 'Wenjuan Li' 'Weizhi Meng' 'Sokratis Katsikas' 'Peng Jiang'] In recent years, the Transport Layer Security (TLS) protocol has enjoyed rapid growth as a security protocol for the Internet of Things (IoT). In its newest iteration, TLS 1.3, the Internet Engineering Task Force (IETF) has standardized a…
Niina Haiminen, Heikki Mannila, Evimaria Terzi
Background There exist many segmentation techniques for genomic sequences, and the segmentations can also be based on many different biological features. We show how to evaluate and compare the quality of segmentations obtained by different techniques and alternative biological features. Results We apply randomization…
Alexander E. Siemenn, Eunice Aissi, Fang Sheng, Armi Tiihonen + 3 more
In materials research, the task of characterizing hundreds of different materials traditionally requires equally many human hours spent measuring samples one by one. We demonstrate that with the integration of computer vision into this material research workflow, many of these tasks can be automated, significantly…