26 papers · ranked by Valyu relevance
Dan-in Jang, A-Hyeon Lee, Hye-Yoon Shin, Hyo-Ryeong Song + 6 more
'Jong-Hwi Park' 'Tae-Bong Kang' 'Sang-Ryong Lee' 'Seung-Hoon Yang' 'Arcangelo Liso' 'Pio Conti'] Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of…
Joshua D. Webster, Domagoj Vucic
Tumor necrosis factor alpha (TNF; TNFα) is a critical regulator of immune responses in healthy organisms and in disease. TNF is involved in the development and proper functioning of the immune system by mediating cell survival and cell death inducing signaling. TNF stimulated signaling pathways are tightly regulated by…
Roman Fischer, Roland E. Kontermann, Klaus Pfizenmaier
Tumor necrosis factor (TNF) is a central regulator of immunity. Due to its dominant pro-inflammatory effects, drugs that neutralize TNF were developed and are clinically used to treat inflammatory and autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease and psoriasis. However, despite their…
Andy Ruiz, Yadira Palacios, Irene Garcia, Leslie Chavez-Galan + 2 more
'Joanna Evans' 'Natalie Eva Nieuwenhuizen'] Tumor necrosis factor (TNF) is one of the main cytokines regulating a pro-inflammatory environment. It has been related to several cell functions, for instance, phagocytosis, apoptosis, proliferation, mitochondrial dynamic. Moreover, during mycobacterial infections, TNF plays…
Subhamoy Jana, Priyanka Roy, Jibitesh Das, Parijat Biswas + 3 more
Tumor Necrosis Factor Receptor 1 (TNFR1) signaling determines cell fate during inflammation, immunopathogenesis, and tumorigenesis. TNFR1 proteins homo-oligomerize into clusters on the plasma membrane. The potential impact of TNFR1 clustering on downstream signaling remains unexplored. Homo-FRET measurements elucidate…
Fatma Ece ÇOPUROĞLU, Fatma Zehra HAPİL, Şükran Burçak YOLDAŞ, Osman Nidai ÖZEŞ
'Osman Nidai ÖZEŞ'] TNF is a pleiotropic cytokine and shows its biological function by binding to its receptors called TNFR1 and TNFR2. While TNFR1 induces apoptosis by activation of caspase-8 via the “death domain”, it also activates IKKα/β, MKK3/6, MKK4/7 by activation of TAK1. Although the TNFR1 signaling pathway is…
Daria M. Yurkina, Elena A. Romanova, Anna V. Tvorogova, Zlata K. Naydenysheva + 5 more
Understanding the exact mechanisms of the activation of proinflammatory immune response receptors is very important for the targeted regulation of their functioning. In this work, we were able to identify the sites of the molecules in the proinflammatory cytokine TNF (tumor necrosis factor) and its TNFR1 (tumor…
Harald Wajant, Andreas Beilhack
An intricate network of molecular and cellular actors orchestrates the delicate balance between effector immune responses and immune tolerance. The pleiotropic cytokine tumor necrosis factor-alpha (TNF) proves as a pivotal protagonist promoting but also suppressing immune responses. These opposite actions are…
Obinna C. Ubah, Eric W. Lake, Stella Priyanka, Ke Shi + 5 more
The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF)-α is synthesized as transmembrane TNF-α (tmTNF-α) where proteolytic processing releases soluble TNF-α (sTNF-α). tmTNF-α can act as either a ligand by activating TNF receptors, or a receptor that transmits outside-to-inside signals (reverse signalling)…
Csilla Uličná, Jozef Uličný
The TNF initiated processes are simulated using our integrative computational model with new quantitative proteomics data obtained on HeLa cell line. In spite of fact, that the model development is based on limited experimental information, with missing data estimated by simulations and parametrization using indirect…
Elsie C. Jacobson, Lekha Jain, Jo K. Perry, Mark H. Vickers + 3 more
Tumor necrosis factor alpha (TNF-α) is a potent cytokine involved in systemic inflammation and immune modulation. Signaling responses that involve TNF-α are context dependent and capable of stimulating pathways promoting both cell death and survival. TNF-α treatment has been investigated as part of a combined therapy…
Anjali Dhall, Sumeet Patiyal, Shubham Choudhury, Shipra Jain + 2 more
Tumor Necrosis Factor alpha (TNF-α) is a pleiotropic pro-inflammatory cytokine that plays a crucial role in controlling signaling pathways within the immune cells. Recent studies reported that the higher expression levels of TNF-α is associated with the progression of several diseases including cancers, cytokine…
Mark J. Cumming, Julien Gibon, Wayne S. Sossin, Philip A. Barker
Tumor necrosis factor receptors (TNFRs) regulate a diverse array of biological functions, including adaptive immunity, neurodevelopment, and many others. Although TNFRs are expressed in all metazoan phyla, a coherent model of the molecular origins of mammalian TNFRs—and how they relate to TNFRs in other phyla—has…
Sophie Steeland, Claude Libert, Roosmarijn E. Vandenbroucke
The first Food and Drug Administration-(FDA)-approved drugs were small, chemically-manufactured and highly active molecules with possible off-target effects, followed by protein-based medicines such as antibodies. Conventional antibodies bind a specific protein and are becoming increasingly important in the therapeutic…
Chuang Li, Yichen Wei, Chao Qin, Shifan Chen + 1 more
line-encoded receptors Authors: ['Chuang Li' 'Yichen Wei' 'Chao Qin' 'Shifan Chen' 'Xiaolong Shao'] - 2 College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China - 3 School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia - 4 Section of Infection and…
Victoria A. Rastrygina, Evgenia I. Deryusheva, Alexey S. Kazakov, Andrey S. Sokolov + 5 more
Tumor Necrosis Factor Superfamily (TNFSF) comprises 20 members of membrane/soluble signaling proteins regulating cell survival, cell proliferation/differentiation, and innate/adaptive immunity. Targeting signaling of TNFSF members is used clinically to treat several autoimmune and oncological diseases, and bone loss.…
Quentin Marcou, Irit Carmi-Levy, Coline Trichot, Vassili Soumelis + 2 more
'Thierry Mora' 'Aleksandra M. Walczak'] Cells of the immune system are confronted with opposing pro- and anti-inflammatory signals. Dendritic cells (DC) integrate these cues to make informed decisions whether to initiate an immune response. Confronted with exogenous microbial stimuli, DC endogenously produce both anti-…
Authors not listed
Acute myocardial infarction (AMI), also known as a heart attack, is a serious medical condition and a leading cause of death worldwide. The diagnosis of AMI relies on a combination of clinical symptoms, physical examination, electrocardiogram (ECG), and blood tests detecting elevated levels of cardiac disease protein…
Elena Agliari, Lorenzo Asti, Adriano Barra, Rossana Scrivo + 2 more
'Guido Valesini' 'Robert S. Wallis'] In this manuscript we apply stochastic modeling to investigate the risk of reactivation of latent mycobacterial infections in patients undergoing treatment with tumor necrosis factor inhibitors. First, we review the perspective proposed by one of the authors in a previous work and…
Julian Ivanov, Rumiana Tenchov, Krittika Ralhan, Kavita Iyer + 2 more
TBK1, or TANK-binding kinase 1, is an enzyme that functions as a serine/threonine protein kinase. It plays a crucial role in various cellular processes, including the innate immune response to viruses, cell proliferation, apoptosis, autophagy, and anti-tumor immunity. Dysregulation of TBK1 activity can lead to…
Maria Bzówka, Weronika Bagrowska, Artur Góra
Toll-like receptors (TLRs) are transmembrane proteins which recognise various molecular patterns and activate signalling that triggers the immune response. In this review, our goal was to summarise how, in recent years, various computational solutions contributed to a better understanding of TLRs, regarding both their…
She Xutong
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges. It is characterized by various pathological markers in the brain——large numbers ofamyloid plaques surrounded by neurons containing neurofibrillary tangles, vascular damage from extensive plaque…
Françoise Schoentgen, Slavica Jonić
PEBPs (PhosphatidylEthanolamine Binding Proteins) form a protein family widely present in the living world since they are encountered in microorganisms, plants and animals. In all organisms PEBPs appear to regulate important mechanisms that govern cell cycle, proliferation, differentiation and motility. In humans…
Maria Bzówka, Weronika Bagrowska, Artur Góra
Toll-like receptors (TLRs) are transmembrane proteins which recognise various molecular patterns and activate signalling that triggers the immune response. In this review, our goal was to summarise how, in recent years, various computational solutions contributed to a better understanding of TLRs, regarding both their…
Alfonso Vivanco-Lira, José-Raúl Nieto-Saucedo
Introduction. Infection by the Human Immunodeficiency Virus can be defined as a chronic viral infection which mainly affects T-cells; this virus displays a set of both structural and regulatory proteins that aid in its survival within the host's cell, through these proteins, can the virus alter the host's gene…
Aakarsh Vermani, Valentina Kouznetsova, Igor Tsigelny
P38-alpha (MAPK14) is a protein kinase that is implicated in the pathological mechanisms of BAG3 P209L myofibrillar myopathy, cancers, Alzheimer’s disease and other diseases like rheumatoid arthritis. Inhibition of p38 has shown promise as treatment for these diseases. Traditional drug discovery methods were unable to…