20 papers · ranked by Valyu relevance
Misbahuddin Rafeeq, Muhammad Afzal, Muhammad Shahid Nadeem, Alaa Hamed Habib + 4 more
TNFR1 is a type I transmembrane receptor with four cysteine-rich domains (CRD1-CRD4): CRD1 stabilizes pre-assembly, CRD2-CRD3 contains the TNF interface, and CRD4 positions binding near the membrane to couple with intracellular death domain signaling. This signals NF-κB-mediated survival, caspase-8-mediated apoptosis…
Ricardo Antonia, Eveliina Karelehto, Kan Toriguchi, Mary Matli + 3 more
Previous work demonstrated that the Signal Transducer and Activator of Transcription 3 (STAT3) is activated downstream of the Type 1 TNF Receptor. However, whether and how STAT3 regulates gene expression downstream of TNFR1 has not been elucidated. Global transcriptome analysis by RNA sequencing was performed in wild…
Subhamoy Jana, Priyanka Roy, Jibitesh Das, Parijat Biswas + 3 more
Tumor Necrosis Factor Receptor 1 (TNFR1) signaling determines cell fate during inflammation, immunopathogenesis, and tumorigenesis. TNFR1 proteins homo-oligomerize into clusters on the plasma membrane. The potential impact of TNFR1 clustering on downstream signaling remains unexplored. Homo-FRET measurements elucidate…
Safina Gadeock, Nandini Girish, Cambrian Y. Liu, Ying Huang + 2 more
Anti-tumor necrosis factor (anti-TNF) is a mainstay of inflammatory bowel disease (IBD) therapy but fails in many patients. Although TNF has pro-inflammatory effects, depletion of TNF receptor 1 (TNFR1) paradoxically exacerbates chronic colitis. Because colitis induces remodeling of mesenchymal cell populations, which…
Tamim Ahsan, Abu Ashfaqur Sajib
Background Tumor necrosis factor alpha (TNFA) is an important cytokine that influences multiple biological processes. It is one of the key mediators of acute and chronic systemic inflammatory reactions and plays a central role in several autoimmune diseases. A number of approved monoclonal antibodies (mAbs) are widely…
Daria M. Yurkina, Elena A. Romanova, Anna V. Tvorogova, Zlata K. Naydenysheva + 5 more
Understanding the exact mechanisms of the activation of proinflammatory immune response receptors is very important for the targeted regulation of their functioning. In this work, we were able to identify the sites of the molecules in the proinflammatory cytokine TNF (tumor necrosis factor) and its TNFR1 (tumor…
Chan Seok Lim, Jisun Lee, Ji Won Kim, Jie-Oh Lee
We report the cryo-EM structures of clusters of TNF receptor family proteins, TNFR1 and BAFFR. The receptor-ligand complexes were anchored to a flat lipid layer to mimic the membrane-bound state. We observed that the TNFα-TNFR1 complex forms highly ordered binary, bent, trigonal, and linear quadruple clusters of…
Jiangnan Zhang, Huijian Zhao, Qianqian Zhou, Xiaoyue Yang + 4 more
'Haoran Qi' 'Yongxing Zhao' 'Longhua Yang' 'Chan Kyung Kim'] Activating tumor necrosis factor receptor 1 (TNFR1) with tumor necrosis factor alpha (TNFα) is one of the key pathological mechanisms resulting in the exacerbation of rheumatoid arthritis (RA) immune response. Despite various types of drugs being available…
Youguang Wang, Na Yin, Min Peng
Targeted protein degradation (TPD) relies on molecules engaging host protein degradation machinery. Here, we developed a novel TPD platform based on antigen endocytosis and degradation by chimeric antigen receptor (CAR) T cells. T cells expressing a CAR with TNFR1 as the antigen-binding domain (TNFR1T) were able to…
Daria M. Yurkina, Elena A. Romanova, Kirill A. Shcherbakov, Rustam H. Ziganshin + 3 more
'Rustam H. Ziganshin' 'Denis V. Yashin' 'Lidia P. Sashchenko' 'Sonia Emanuele'] Receptors of cytokines are major regulators of the immune response. In this work, we have discovered two new ligands that can activate the TNFR1 (tumor necrosis factor receptor 1) receptor. Earlier, we found that the peptide of the Tag…
Obinna C. Ubah, Eric W. Lake, Stella Priyanka, Ke Shi + 5 more
The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF)-α is synthesized as transmembrane TNF-α (tmTNF-α) where proteolytic processing releases soluble TNF-α (sTNF-α). tmTNF-α can act as either a ligand by activating TNF receptors, or a receptor that transmits outside-to-inside signals (reverse signalling)…
Cristian R. Smulski
Tumor necrosis factor alpha (TNF) is a key modulator of immune responses. Its ability to trigger pro-survival and apoptotic or necroptotic signaling pathways has long been the subject of intense research. However, its role in inflammatory diseases is far from being fully understood. The outcome of signaling, following…
T. V. Tregubchak, S. N. Shchelkunov
Immune-mediated inflammatory diseases affect a substantial proportion of the global population, and tumor necrosis factor (TNF) plays a central role in their pathogenesis. The most common diseases in clude rheumatoid arthritis (RA), Crohn’s disease, psoriasis, multiple sclerosis, and septic shock. All of these…
Yadira Palacios, Leslie Chavez-Galan, Jean Jacques, Vanden Eynde + 1 more
'Annie Mayence'] The study of cytokine storm in COVID-19 has been having different edges in accordance with the knowledge of the disease. Various cytokines have been the focus, especially to define specific treatments; however, there are no conclusive results that fully support any of the options proposed for emergency…
Auddya, Debabrata, Rudraraju, Shiva
Traumatic Brain Injury (TBI) is associated with an impact or concussion to the head with the injury being specifically characterized through pathological degradation at various biological length scales. To quantify the sequence of events following TBI, various mechanical modeling techniques have been proposed in the…
Chuang Li, Yichen Wei, Chao Qin, Shifan Chen + 1 more
line-encoded receptors Authors: ['Chuang Li' 'Yichen Wei' 'Chao Qin' 'Shifan Chen' 'Xiaolong Shao'] - 2 College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China - 3 School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia - 4 Section of Infection and…
Authors not listed
Acute myocardial infarction (AMI), also known as a heart attack, is a serious medical condition and a leading cause of death worldwide. The diagnosis of AMI relies on a combination of clinical symptoms, physical examination, electrocardiogram (ECG), and blood tests detecting elevated levels of cardiac disease protein…
Julian Ivanov, Rumiana Tenchov, Krittika Ralhan, Kavita Iyer + 2 more
TBK1, or TANK-binding kinase 1, is an enzyme that functions as a serine/threonine protein kinase. It plays a crucial role in various cellular processes, including the innate immune response to viruses, cell proliferation, apoptosis, autophagy, and anti-tumor immunity. Dysregulation of TBK1 activity can lead to…
Maria Bzówka, Weronika Bagrowska, Artur Góra
Toll-like receptors (TLRs) are transmembrane proteins which recognise various molecular patterns and activate signalling that triggers the immune response. In this review, our goal was to summarise how, in recent years, various computational solutions contributed to a better understanding of TLRs, regarding both their…
She Xutong
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges. It is characterized by various pathological markers in the brain——large numbers ofamyloid plaques surrounded by neurons containing neurofibrillary tangles, vascular damage from extensive plaque…