21 papers · ranked by Valyu relevance
Tobias Bergmiller, Ekaterina Krasnopeeva, Srdjan Sarikas, Nela Nikolic + 1 more
Since bacteria lack a nucleus, the location of mRNA molecules is determined by the different characteristics of the encoded proteins, and the transcriptome is spatially arranged into cytosolic and membrane-associated mRNA. While translation of membrane protein-encoding mRNA has been studied in great mechanistic detail…
Steven C King
Background In establishing structure-function relationships for membrane transport proteins, the interpretation of phenotypic changes can be problematic, owing to uncertainties in protein expression levels, sub-cellular localization, and protein-folding fidelity. A dual-label competitive transport assay called…
Shuhua Fu, Parker Wilson, Bo Zhang
Cells can transcribe different isoforms of a gene by using distinct Transcriptional Start Regions (TSRs), which are recognized by RNA-Polymerase II and regulated by cell-type-specific expressed transcription factors, eventually forming tissue and cell-type-specific expression during development. However, how the…
Siena J. Glenn, Zealon Gentry-Lear, Michael Shavlik, Michael J. Harms + 2 more
Enterobacteriaceae bacteria are prone to opportunistic pathogenic behavior during gut dysbiosis, potentially influenced by distinct environmental cues within the compromised gut. Chemosensing systems play a central role in allowing bacteria to perceive and react to physicochemical signals within the gastrointestinal…
Vibeke Krane, Bengt Karlsson, Ottar Ness, Per-Einar Binder
The aim of this study was to explore how teachers and helpers experience that teacher-student relationship (TSR) is developed and promoted in upper secondary school. We also explored their experiences of qualities of TSR with students with mental health problems or at risk of dropping out. The study used a qualitative…
Felix Anne Dikland, Cyrine Fekih, Marius René Jacques Wellenstein, Ricella Souza da Silva + 6 more
The tumour-stroma ratio (TSR), which refers to the composition of stromal tissue and tumour epithelium of a malignant lesion, is gaining recognition as a promising biomarker in pathology. In 2018, recommendations for quantifying TSR in colorectal carcinoma were published, yet diverse quantification methods are still in…
Xiaqing Pan, Sachin Chachada, C.‐C. Jay Kuo
A robust two-stage shape retrieval (TSR) method is proposed to address the 2D shape retrieval problem. Most state-of-the-art shape retrieval methods are based on local features matching and ranking. Their retrieval performance is not robust since they may retrieve globally dissimilar shapes in high ranks. To overcome…
Jung-Soo Pyo, Nae Yu Kim, Kyueng-Whan Min, Dong-Wook Kang + 1 more
'Sorin Tiberiu Alexandrescu'] Background and Objectives: The present study aimed to elucidate the distribution and the prognostic implications of tumor-stroma ratio (TSR) in various malignant tumors through a meta-analysis. Materials and Methods: This meta-analysis included 51 eligible studies with information for…
Georgina I. Reyes, Caralyn E. Flack, John S. Parkinson
The experimental challenges posed by integral membrane proteins hinder molecular understanding of transmembrane signaling mechanisms. Here, we exploited protein crosslinking assays in living cells to follow conformational and dynamic stimulus signals in Tsr, the Escherichia coli serine chemoreceptor. Tsr mediates…
Emilie-Fleur Neubauer, Angela Z Poole, Philipp Neubauer, Olivier Detournay + 4 more
'Olivier Detournay' 'Kenneth Tan' 'Simon K Davy' 'Virginia M Weis' 'Paul G Falkowski'] The mutualistic endosymbiosis between cnidarians and dinoflagellates is mediated by complex inter-partner signaling events, where the host cnidarian innate immune system plays a crucial role in recognition and regulation of…
Liisa Petäinen, Juha P. Väyrynen, Pekka Ruusuvuori, Ilkka Pölönen + 2 more
'Sami Äyrämö' 'Teijo Kuopio'] Tumor-stroma ratio (TSR) is a prognostic factor for many types of solid tumors. In this study, we propose a method for automated estimation of TSR from histopathological images of colorectal cancer. The method is based on convolutional neural networks which were trained to classify…
Sophie C. Hagenaars, Kiki M. H. Vangangelt, Gabi W. Van Pelt, Zsófia Karancsi + 5 more
'Zsófia Karancsi' 'Rob A. E. M. Tollenaar' 'Andrew R. Green' 'Emad A. Rakha' 'Janina Kulka' 'Wilma E. Mesker'] Purpose The tumor-stroma ratio (TSR) has repeatedly proven to be correlated with patient outcomes in breast cancer using large retrospective cohorts. However, studies validating the TSR often show variability…
Sonja Kersten, Fernando A. Rabanal, Johannes Herrmann, Martin Hess + 3 more
Rapid adaptation of weeds to herbicide applications in agriculture through resistance development is a widespread phenomenon. In particular, the grass Alopecurus myosuroides is an extremely problematic weed in cereal crops with the potential to manifest resistance in the course of only a few generations. Target-site…
Sara F. Hartke, Ari Athair, Owen Williams, Jennifer A. Franck
Understanding the intricate dynamics of cross-flow turbines (CFT) is critical to the improvement of performance and optimal control strategies. The current study numerically investigates intracycle control by modulating the angular velocity as a function of blade position for a 2-bladed NACA0018 turbine at a lab-scale…
Authors not listed
The calculation of transition state (TS) geometries is essential for understanding reaction mechanisms and rational synthetic methodology design. However, traditional methods like density functional theory (DFT) are often too computationally expensive for large-scale TS identification and are significantly slower than…
Authors not listed
Catalytic reactions involving multiple cycles are common in many key organic transformations. We report a detailed mechanistic analysis of one such network of “nested” cycles, the Ni-catalyzed cross-coupling of alkyl sulfonyl hydrazides with (hetero)aryl halides, employing a battery of techniques including temperature…
Authors not listed
Efficient and reliable identification of transition states (TS) is critical for reaction modelling. Among the approaches available, the combination of double-ended TS search with eigenvector-following, referred to as “hierarchical TS search”, is an effective tool to locate TSs starting from reactant and product…
Ningfei Wang, Shaoyuan Xie, Takami Sato, Yunpeng Luo + 2 more
Recognition: A Commercial Systems Perspective Authors: ['Ningfei Wang' 'Shaoyuan Xie' 'Takami Sato' 'Yunpeng Luo' 'Kaidi Xu' 'Qi Alfred Chen'] Abstract—Traffic Sign Recognition (TSR) is crucial for safe and correct driving automation. Recent works revealed a general vulnerability of TSR models to physical-world…
M. J. Keith
The High Time Resolution Universe survey for pulsars and transients is the first truly all-sky pulsar survey, taking place at the Parkes Radio Telescope in Australia and the Effelsberg Radio Telescope in Germany. Utilising multibeam receivers with custom built all-digital recorders the survey targets the fastest…
Duncan Neill, David Tsang, Hendrik van Eerten, Geoffrey Ryan + 1 more
'William G. Newton'] Resonant Shattering flares (RSFs) are bursts of gamma-rays expected to be triggered by tidal resonance of a neutron star (NS) during binary inspiral. They are strongly dependent on the magnetic field strength at the surface of the NS. By modelling these flares as being the result of multiple…
Authors not listed
Photoinduced charge separation (CS) in organic solids is critical for energy conversion and information storage. However, the lifetime of the CS state is fundamentally limited by charge carrier recombination. Here we demonstrate long-term stabilization of CS states in a purely organic donor-acceptor-trap system by…