21 papers · ranked by Valyu relevance
Martín Muñoz-López, José L. García-Pérez
Repeated DNA makes up a large fraction of a typical mammalian genome, and some repetitive elements are able to move within the genome (transposons and retrotransposons). DNA transposons move from one genomic location to another by a cut-and-paste mechanism. They are powerful forces of genetic change and have played a…
Asmaa H. Hassan, Morad M. Mokhtar, Achraf El Allali
Transposable elements (TEs) are indispensable components of eukaryotic genomes that play diverse roles in gene regulation, recombination, and environmental adaptation. Their ability to mobilize within the genome leads to gene expression and DNA structure changes. TEs serve as valuable markers for genetic and…
Wanxiangfu Tang, Ping Liang
Mobile elements generated via DNA transposition constitute ∼50% of the primate genomes. As a result of past and ongoing activity, DNA transposition is responsible for generating inter- and intra-species genomic variations, and it plays important roles in shaping genome evolution and impacting gene function. While…
Adekanmi Daniel Omole, Peter Czuppon
Transposable elements are DNA sequences that can move and replicate within genomes. Broadly speaking, two element types exist: autonomous elements, which encode the necessary enzymes for transposition, and nonautonomous elements that rely on these enzymes produced by autonomous elements for their transposition.…
Anuj Kumar
Since Barbara McClintock’s groundbreaking discovery of mobile DNA sequences some 70 years ago, transposable elements have come to be recognized as important mutagenic agents impacting genome composition, genome evolution, and human health. Transposable elements are a major constituent of prokaryotic and eukaryotic…
Roshan Prizak, Lennart Hilbert
Transposons, which are DNA sequences that can move to new positions in the genome, make up a large fraction of eukaryotic genomes and occur in clusters. The insertion of transposons into the genome is hindered by compact folding of chromatin, supposedly preventing aberrant or even pathogenic insertion. Chromatin can…
Wanxiangfu Tang, Ping Liang
Mobile elements (MEs) can be divided into two major classes based on their transposition mechanisms as retrotransposons and DNA transposons. DNA transposons move in the genomes directly in the form of DNA in a cut-and-paste style, while retrotransposons utilize an RNA-intermediate to transpose in a “copy-and-paste”…
Jinghan Tian, Doudou Tong, Zhendong Li, Erqiang Wang + 7 more
'Hangya Lv' 'Zhendan Hu' 'Fang Sun' 'Guoping Wang' 'Min He' 'Tian Xia'] Title: Abstract Transposons, as non-viral integration vectors, provide a secure and efficient method for stable gene delivery. In this study, we have discovered Mage (MG), a novel member of the piggyBac(PB) family, which exhibits strong…
Almorò Scarpa, Riccardo Pianezza, Filip Wierzbicki, Robert Kofler
Transposable element invasions have a profound impact on the evolution of genomes and phenotype. It is thus an important open question on how often such TE invasions occur. Based on strains sampled at different times, previous work showed that four different TE families invaded D. melanogaster during the 20^th^…
Nitzan Kutnowski, George E. Ghanim, Yeon Lee, Donald C. Rio
Transposable elements are mobile DNA segments that are found ubiquitously across the three domains of life. One family of transposons, called P elements, were discovered in the fruit fly Drosophila melanogaster. Since their discovery, P element transposase-homologous genes (called THAP-domain containing 9 or THAP9)…
Jasper R.L. Depotter, Johana C. Misas Villamil, Gunther Doehlemann
Plants are subjected to different types of threats that require appropriate physiological responses to counteract them. Signalling peptides are produced under specific conditions and elicit physiological changes. PROZIP1 encodes such a signalling peptide, Zip1, that induces salicylic acid defence responses in maize…
Daniel Heinzelmann, Franziska Reuss, Nikolas Zeh, Robin Nilson + 7 more
Transposases revolutionized the field of genetic engineering, yet the scarcity of functional systems remains a challenge. In response, we conducted a metagenomic screening and identified a novel transposase system from Acyrthosiphon pisum. Through systematic optimization, we enhanced nuclear localization, transposon…
Marie-Véronique Demattei, Sabah Hedhili, Ludivine Sinzelle, Christophe Bressac + 8 more
'Christophe Bressac' 'Sophie Casteret' 'Nathalie Moiré' 'Jeanne Cambefort' 'Xavier Thomas' 'Nicolas Pollet' 'Pascal Gantet' 'Yves Bigot' 'Richard Cordaux'] Mariner-like elements (MLEs) are widespread transposable elements in animal genomes. They have been divided into at least five sub-families with differing host…
Xiu-Ming Guo, Qian-Qian Zhang, Yi-Wen Sun, Xia-Yun Jiang + 1 more
'Shu-Ming Zou'] Tc1-like transposons consist of an inverted repeat sequence flanking a transposase gene that exhibits similarity to the mobile DNA element, Tc1, of the nematode, Caenorhabditis elegans. They are widely distributed within vertebrate genomes including teleost fish; however, few active Tc1-like…
Martin Carr, Douda Bensasson, Casey Bergman
Saccharomyces cerevisiae is one of the premier model systems for studying the genomics and evolution of transposable elements. The availability of the S. cerevisiae genome led to unprecedented insights into its five known transposable element families (the LTR retrotransposons Ty1-Ty5) in the years shortly after its…
George E. Ghanim, Donald C. Rio, Felipe Karam Teixeira
P elements were first discovered in the fruit fly Drosophila melanogaster as the causative agents of a syndrome of aberrant genetic traits called hybrid dysgenesis. This occurs when P element-carrying males mate with females that lack P elements and results in progeny displaying sterility, mutations and chromosomal…
Alexandr V. Vikhorev, Michael M. Rempel, Oksana Polesskaya, Ivan Savelev + 1 more
Points Revealed by Micro-C Data Analysis Authors: ['Alexandr V. Vikhorev' 'Michael M. Rempel' 'Oksana Polesskaya' 'Ivan Savelev' 'Max Myakishev-Rempel'] Transposable elements (TEs) constitute a significant portion of eukaryotic genomes, yet their role in chromatin organization remains poorly understood. This study…
Rebekah L. Rogers, John P. Wares, Jeffrey T. Garner
Nearly-neutral theory predicts that evolution will operate differently in small populations. Adaptive change is less common, and detrimental variation may accumulate. We test these theories with a new reference genome for a critically endangered freshwater mussel. Results for SNPs and duplications are fully consistent…
Authors not listed
Molecular mechanisms governing initiation steps of the assembly of thousands of endogenous multi-protein complexes (EMCs) remain incompletely understood. Here, multiple lines of observations are reported reflecting the biological functions-aligned initiation sequence of hybrid assembly pathways (HAPs) of EMCs. HAPs…
Justin P. Blumenstiel, Miaomiao He, Casey Bergman
| 1 | | | --- | --- | | 2 | | | 3 | | | 4 | An age-of-allele test of neutrality for transposable | | 5 | element insertions. | | 6 | | | 7 | Justin P. Blumenstiel , Xi Chen , Miaomiao He§ and Casey M. | | 8 | Bergman§ | | 9 | | | 10 | * Department of Ecology and Evolutionary Biology, University of | | 11 | Kansas…
Huda Al-Nayyef, Christophe Guyeux, Jacques M. Bahi
Insertion Sequences (ISs) are small DNA segments that have the ability of moving themselves into genomes. These types of mobile genetic elements (MGEs) seem to play an essential role in genomes rearrangements and evolution of prokaryotic genomes, but the tools that deal with discovering ISs in an efficient and accurate…