13 papers · ranked by Valyu relevance
Anil K. Challa, Evan R. Boitet, Ashley N. Turner, Larry W. Johnson + 6 more
'Daniel Kennedy' 'Ethan R. Downs' 'Katherine M. Hymel' 'Alecia K. Gross' 'Robert A. Kesterson' 'Edward E Schmidt'] Tyrosinase is a key enzyme in melanin biosynthesis. Mutations in the gene encoding tyrosinase (Tyr) cause oculocutaneous albinism (OCA1) in humans. Alleles of the Tyr gene have been useful in studying…
Davide Seruggia, Almudena Fernández, Marta Cantero, Ana Fernández-Miñán + 3 more
Control of gene expression is dictated by cell-type specific regulatory sequences that physically organize the structure of chromatin, including promoters, enhancers and insulators. While promoters and enhancers convey cell-type specific activating signals, insulators prevent the cross-talk of regulatory elements…
Yanchao Liu, Pan Liu, Tong Ren, Yang Gao + 11 more
'Chen Chen' 'Liqin Ji' 'Xiaoyou Hong' 'Xiaoli Liu' 'Chengqing Wei' 'Xinping Zhu' 'Zhangjie Chu' 'Wei Li' 'Alexander V. Ereskovsky'] In farmed animals, body color is not only an ecological trait but also an important trait that influences the commercial value of the animals. Melanin plays an important role in the…
Xueping Wang, Yalan Liu, Hongsheng Chen, Lingyun Mei + 8 more
'Lu Jiang' 'Zhijie Niu' 'Jie Sun' 'Hunjin Luo' 'Jiada Li' 'Yong Feng' 'Andrzej T Slominski'] TYR, DCT and MITF are three important genes involved in maintaining the mature phenotype and producing melanin; they therefore participate in neural crest cell development into melanocytes. Previous studies have revealed that…
Davide Seruggia, Almudena Fernández, Marta Cantero, Ana Fernández-Miñán + 3 more
'Ana Fernández-Miñán' 'José Luis Gomez-Skarmeta' 'Pawel Pelczar' 'Lluis Montoliu'] Control of gene expression is dictated by cell-type specific regulatory sequences that physically organize the structure of chromatin, including promoters, enhancers and insulators. While promoters and enhancers convey cell-type specific…
Qianqian Jin, Chuncao Huo, Wenhao Yang, Kaidi Jin + 10 more
'Yanxin Zheng' 'Baoyu Huang' 'Lei Wei' 'Meiwei Zhang' 'Yijing Han' 'Xuekai Zhang' 'Yaqiong Liu' 'Xiaotong Wang' 'Yuri V. Sergeev'] Retinoic acid (RA) plays important roles in various biological processes in animals. RA signaling is mediated by two types of nuclear receptors, namely retinoic acid receptor (RAR) and…
Kacie J. Meyer, Demelza R. Larson, S. Scott Whitmore, Carly J. van der Heide + 11 more
Central corneal thickness is a quantitative trait with important associations to human health. In a phenotype-driven approach studying corneal thickness of congenic derivatives of C57BLKS/J and SJL/J mice, the critical region for a quantitative trait locus influencing corneal thickness, Cctq1a, was delimited to a…
Olga Shchagina, Anna Stepanova, Polina Mishakova, Vitaliy Kadyshev + 9 more
'Nina Demina' 'Ludmila Bessonova' 'Sofya Ionova' 'Daria Guseva' 'Andrey Marakhonov' 'Rena Zinchenko' 'Sergey Kutsev' 'Aleksander Polyakov' 'Marie Černá'] Background: oculocutaneous albinism (OCA) is a hereditary impairment of skin, hair, and eye pigmentation. The most common form of albinism is autosomal recessive…
Guillermo Abascal-Palacios, Laura Jochem, Carlos Pla-Prats, Fabienne Beuron + 1 more
Retrotransposons are endogenous elements that have the ability to mobilise their DNA and integrate at different locations in the host genome. In budding yeast, the Ty3 retrotransposon integrates with an exquisite specificity in a narrow window upstream of RNA Polymerase III-transcribed genes, such as the genes of…
Alicia C. Salinero, Elisabeth R. Knoll, Z. Iris Zhu, David Landsman + 2 more
The Ty1 retrotransposons present in the genome of Saccharomyces cerevisiae belong to the large class of mobile genetic elements that replicate via an RNA intermediary and constitute a significant portion of most eukaryotic genomes. The retromobility of Ty1 is regulated by numerous host factors, including several…
E. Dalles Keyes, Marcus C. Mifflin, Maxwell J. Austin, Brighton J. Alvey + 4 more
Inspired by Nature's wide range of oxidation-induced modifications to install cross-links and cycles at tyrosine (Tyr) and other phenol-containing residue side chains, we report a Tyr-selective strategy for the preparation of Tyr-linked cyclic peptides. This approach leverages N4-substituted 1,2,4 triazoline-3,5-diones…
Authors not listed
SIMPLE SUMMARY TP53 gene is really important for keeping our cells healthy. It does this by fixing damaged DNA, managing cell growth, and telling cells to die if they're too damaged to repair. But when TP53 has mutations,these defenses stop working, and cells start growing out of control. One of the big problems in…
Jay C. Brown
The study described here was carried out to explore the properties of a novel DNA sequence element found concentrated in five human chromosomes, 16-18, 20 and Y. The new DNA sequence, 1519 bp in length and called t1519, was found throughout the high abundance chromosomes, but only rarely elsewhere in the genome. BLAST…