22 papers · ranked by Valyu relevance
Mansi Chaudhary, Omkar Mahadeo Desai, Poonam Sharma, Sharanya Premraj + 2 more
Unlike mammals, the Muller glia reprogramming in zebrafish retina restores vision after an acute retinal injury. Here, we explored the Ying yang (Yy1) protein and its multi-faceted roles in different phases of retina regeneration. We show that the acetylation and deacetylation status of Yy1 contribute to its…
Michael L. Atchison
During B cell development, long-distance DNA interactions are needed for V(D)J somatic rearrangement of the immunoglobulin (Ig) loci to produce functional Ig genes, and for class switch recombination (CSR) needed for antibody maturation. The tissue-specificity and developmental timing of these mechanisms is a subject…
Gustavo Ulises Martinez-Ruiz, Abigail Morales-Sanchez, Angel Francisco Pacheco-Hernandez
'Angel Francisco Pacheco-Hernandez'] Accumulating evidence strongly indicates that the presence of cancer stem cells (CSCs) leads to the emergence of worse clinical scenarios, such as chemo- and radiotherapy resistance, metastasis, and cancer recurrence. CSCs are a highly tumorigenic population characterized by…
Raed Rizkallah, Karen E. Alexander, Ari Kassardjian, Bernhard Lüscher + 2 more
'Bernhard Lüscher' 'Myra M. Hurt' 'Anja-Katrin Bielinsky'] Yin-Yang 1 (YY1) is an essential multifunctional zinc-finger protein. It has been shown over the past two decades to be a critical regulator of a vast array of biological processes, including development, cell proliferation and differentiation, DNA repair, and…
Chenxi Xu, Damu Wu, Bo Pan, Xiaoxiao Ren + 10 more
Genetic and epigenetic aberrations often act in concert to establish oncogenic transcriptomic programs in aggressive cancers. For example, the development of castration-resistant prostate cancer (CRPC), an advanced prostate cancer form, is closely associated with over-expression and/or hyper-activation of transcription…
Xuan Pan, Morgan Jones, Jie Jiang, Kristina Zaprazna + 5 more
'Warren Pear' 'Ivan Maillard' 'Michael L. Atchison' 'Maurizio Pesce'] Ying Yang 1 (YY1) is a multifunctional Polycomb Group (PcG) transcription factor that binds to multiple enhancer binding sites in the immunoglobulin (Ig) loci and plays vital roles in early B cell development. PcG proteins have important functions in…
Chenxi Xu, Yi-Hsuan Tsai, Phillip Galbo, Weida Gong + 13 more
Castration-resistant prostate cancer (CRPC) is a terminal disease, demanding a better understanding of its pathogenesis. Targeted therapy needs to be developed for CRPC due to its heterogeneity and resistance to current treatments. Here, through cistrome study of YY1, a transcription factor significantly overexpressed…
Karabi Saha, Grace I. Nielsen, Raj Nandani, Lingqi Kong + 2 more
Long interspersed element type 1 (LINE-1, L1) is an active autonomous transposable element (TE) in the human genome. The first step of L1 replication is transcription, which is controlled by an internal RNA polymerase II promoter in the 5’ untranslated region (UTR) of a full-length L1. It has been shown that…
Zhiying Shao, Wendong Yang, Xiannan Meng, Minle Li + 5 more
2## YY1 SEQUENCE AND STRUCTURE YY1 is a member of the GLI-Kruppel family and polycomb protein family. Human YY1 gene, located in the telomere region q32.2 of chromosome No. 14, encodes a highly conserved protein of 414 amino acids with multiple functional domains including a transcriptional activation domain, a…
Wenchao Li, SaiSai Chen, Jian Lu, Weipu Mao + 19 more
Immune checkpoint therapy for prostate cancer (PCa) has failed in clinical trials; however, the precise underlying mechanisms involved remain elusive. PCa, a classic "immune-cold” tumor, is characterized by an immunosuppressive tumor microenvironment. Within this milieu, macrophages, the predominant immune cell…
Wenmeng Wang, Shiyao Qiao, Guangyue Li, Cuicui Yang + 5 more
As an oncogenic transcription factor, Yin Yang 1 (YY1) regulates enhancer and promoter connection. However, gaps still exist in understanding how YY1 coordinates coactivators and chromatin elements to assemble super-enhancers. Here, we demonstrate that YY1 activates FOXM1 gene expression through forming liquid-liquid…
Yuri Ofusa, Sanae Nishio, Tatsuji Enoki, Junichi Mineno + 3 more
Adeno-associated virus (AAV) vectors are widely used in gene therapy, whereas low manufacturing efficiency and a large proportion of empty capsids are major obstacles. This study focused on the Yin Yang 1 (YY1) binding motif (YY1-motif) and investigated the effect of its presence or insertion upstream of the Replicase…
Jia Guo, Hongwei Yao, Xin Lin, Haodong Xu + 5 more
'Gang Liu' 'Patricia Sime' 'Carol Feghali-Bostwick'] A key feature of lung fibrosis is the accumulation of myofibroblasts. Interleukin 13 (IL-13) is a pro-fibrotic mediator that directly and indirectly influences the activation of myofibroblasts. Transforming growth factor beta (TGF-β) promotes the differentiation of…
Authors not listed
Here, we have reported the computational design of a new class of ylides, elusive carbon-carbon ylides featuring zwitterionic σ-bonds, derived from the norbornane-2,6-dione framework. Utilizing the state-of-the-art computational methods, we have demonstrated that appropriate substitutions on this scaffold can stabilize…
Irene Goti, Stefano Condio, Cecilia Clivati, Matias Risaro + 5 more
'Michele Gozzelino' 'Giovanni Antonio Costanzo' 'Filippo Levi' 'Davide Calonico' 'Marco Pizzocaro'] Abstract. We present the new absolute frequency measurement of ytterbium (171Yb) obtained at INRiM with the optical lattice clock IT-Yb1 against the cryogenic caesium ( 133Cs) fountain IT-CsF2, evaluated through a…
Huidong Kim, Myoung-Sun Heo, Chang Yong Park, Dai-Hyuk Yu + 1 more
'Won-Kyu Lee'] We report a measurement of the absolute frequency of the 1 S0- 3 P0 transition in the 171Yb optical lattice clock at KRISS (KRISS-Yb1) for 14 months, which was referenced to the SI second by primary and secondary standards worldwide via TAI (International Atomic Time). The determined absolute frequency…
Huidong Kim, Myoung-Sun Heo, Won-Kyu Lee, Chang Yong Park + 3 more
'Hyun-Gue Hong' 'Sang-Wook Hwang' 'Dai-Hyuk Yu'] We measured the absolute frequency of the 1 S0–3 P0 transition of 171Yb atom confined in a one-dimensional optical lattice relative to the SI second. The determined frequency was 518 295 836 590 863.38(57) Hz. The uncertainty was reduced by a factor of 14 compared with…
L. Nenadovic, J. J. McFerran
We have carried out concurrent optical frequency measurements of the (6s 2 ) 1S0 − (6s6p) 3P1 (F = 3 2 ) and (6s 2 ) 1S0 − (6s6p) 3P0 transitions in 171Yb, and in so doing have determined the frequency separation between the 3P0 (F = 1 2 ) and 3P1 (F = 3 2 ) levels with an uncertainty in the ppb range. The knowledge of…
Takumi Kobayashi, Daisuke Akamatsu, Yusuke Hisai, Takehiko Tanabe + 5 more
'Hajime Inaba' 'Tomonari Suzuyama' 'Feng-Lei Hong' 'Kazumoto Hosaka' 'Masami Yasuda'] Abstract—We report an uncertainty evaluation of an 171Yb optical lattice clock with a total fractional uncertainty of 3.6 × 10−16, which is mainly limited by the lattice-induced light shift and the blackbody radiation shift. Our…
Bingyi Chen, Dan Xie, Stephen S.‐T. Yau, Shing–Tung Yau + 1 more
Here X is conjectured to be an isolated rational Gorenstein singularity [XY] with a good C ∗ action, and we take string coupling gs → 0 and go to infrared limit [SV, GKP]. These rational Gorenstein singularities naturally appear in the degeneration limit of compact Calabi-Yau three manifolds, and in fact general…
C. Fry, M. Thoennessen
| 1. | Introduction | 2 | | --- | --- | --- | | 2. | Discovery of 139−169Dy | 3 | | 3. | Discovery of 140−172Ho | 10 | | 4. | Discovery of 144−175Er | 17 | | 5. | Discovery of 145−177Tm | 25 | | 6. | Discovery of 149−180Yb | 33 | | 7. | Summary | 40 | | | References | 40 | | | Explanation of Tables | 47 | | 8. | Table…
Jack Emerson-King, Gemma Gransbury, George Whitehead, Iñigo Vitorica-Yrezabal + 4 more
The isolation of formally two-coordinate lanthanide (Ln) complexes is synthetically challenging, due to predominantly ionic Ln bonding regimes favoring high coordination numbers. In 2014 some of us predicted that a near-linear dysprosium bis(amide) cation [Dy{N(SiiPr3)2}2]+ could provide a single-molecule magnet (SMM)…