24 papers · ranked by Valyu relevance
P Jayanthi, Elizabeth Joshua, K Ranganathan
Ageing processes are defined as those that increase the susceptibility of individuals, as they grow older, to the factors that eventually lead to death. It is a complex multi-factorial process, where several factors may interact simultaneously and may operate at many levels of functional organization. The heterogeneity…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Rumiana Tenchov, Janet M. Sasso, Xinmei Wang, Qiongqiong Angela Zhou
and Progression and Age-Related Diseases: A Landscape View of Research Advancement Authors: ['Rumiana Tenchov' 'Janet M. Sasso' 'Xinmei Wang' 'Qiongqiong Angela Zhou'] Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic…
Tamas Fulop, Anis Larbi, Abdelouahed Khalil, Alan A. Cohen + 1 more
'Jacek M. Witkowski'] Growing elderly populations, sometimes referred to as gray (or silver) tsunami, are an increasingly serious health and socioeconomic concern for modern societies. Science has made tremendous progress in the understanding of aging itself, which has helped medicine to extend life expectancies. With…
Hema Sharma Datta, S. K. Mitra, Rangesh Paramesh, Bhushan Patwardhan
Aging is a complex phenomenon, a sum total of changes that occur in a living organism with the passage of time and lead to decreasing ability to survive stress, increasing functional impairment and growing probability of death. There are many theories of aging and skin remains the largest organ of the study. Skin aging…
Alessandro Fontana, Marios Kyriazis
At any moment in time, evolution is faced with a formidable challenge: refining the already highly optimised design of biological species, a feat accomplished through all preceding generations. In such a scenario, the impact of random changes (the method employed by evolution) is much more likely to be harmful than…
David Gems
From a biological perspective aging (senescence) appears to be a form of complex disease syndrome, though this is not the traditional view. This essay aims to foster a realistic understanding of aging by scrutinizing ideas old and new. The conceptual division between aging-related diseases and an underlying…
T. Roget, P. Jolivet, S. Méléard, M. Rera
The possibility of ageing being directly selected through evolution has been discussed for the past hundred years. As ageing is occurring, by definition, only late in life - i.e. after the organismal development is finalized -, many think that it cannot be actively selected for as a process. In addition, by decreasing…
Tamàs Fülöp, Mathieu Desroches, Fernando Antônio Nóbrega Santos, Serafim Rodrigues
'Serafim Rodrigues'] Living systems are subject to the arrow of time; from birth, they undergo complex transformations (self-organization) in a constant battle for survival, but inevitably ageing and disease trap them to death. Can ageing be understood and eventually reversed? What tools can be employed to further our…
Francis Heylighen
Aging is analyzed as the spontaneous loss of adaptivity and increase in fragility that characterizes dynamic systems. Cybernetics defines the general regulatory mechanisms that a system can use to prevent or repair the damage produced by disturbances. According to the law of requisite variety, disturbances can be held…
Leonard Hayflick
Age changes can occur in only two fundamental ways: by a purposeful program driven by genes or by random, accidental events. It is a cornerstone of modern biology that a purposeful genetic program drives all biological processes that occur from the beginning of life to reproductive maturation. However, once…
Yin Wang, Tao Huang, Xianzheng Sha, Yixue Li + 1 more
Aging is a fundamental biological process, where key bio-markers interact with each other and synergistically regulate the aging process. Thus aging dysfunction will induce many disorders. Finding aging markers and re-constructing networks based on multi-omics data (i.e. methylation, transcriptional and so on) are…
Alexander Muacevic, John R Adler, Víctor Manuel Mendoza-Núñez, Ana Belén Mendoza-Soto
'Ana Belén Mendoza-Soto'] Ageism is a type of discrimination characterized by negative social representations of old age and aging, with prejudices and stereotypes that cause rejection and marginalization of older adults, generally considering them as fragile and unproductive. For this reason, it is recognized as one…
Andrey V. Kuznetsov
This study proposes using accumulated neurotoxicity, defined as the time integral of Aβ oligomer concentration, as a biomarker for neuronal aging. A relationship between biological age and accumulated neurotoxicity is proposed. Numerical analysis guided the development of a new analytical solution linking the…
Andrey V. Kuznetsov
This study proposes using accumulated neurotoxicity, defined as the time integral of Aβ oligomer concentration, as a biomarker for neuronal aging. A relationship between biological age and accumulated neurotoxicity is proposed. Numerical analysis guided the development of a new analytical solution linking the…
Richard Y. Chin
The teleology of aging has been one of the more vexing and controversial question in biology. One potential evolutionary driver of programmed aging is selection pressure from parasites and other infectious organisms. While selection pressure from parasites and other infectious organisms have long been considered by…
Dale Dannefer, Jessica Kelley, Olugbenga Okunade
While aging is a general phenomenon that characterizes virtually all species, human aging entails mechanisms of stability and change that comprise distinct or unique features of the species homo sapiens. Such mechanisms occur in two interrelated but analytically distinguishable domains, an ontogenetic domain…
Peter Lenart, Julie Bienertová-Vašků, Luděk Berec
Since at first sight aging seems to be omnipresent, many authors to this very day regard it as an inevitable consequence of the laws of physics. However, studies published in the past two decades have conclusively shown that a number of organisms do not age, or at least do not age on a scale comparable with other aging…
Lev Salnikov
This paper proposes an original theory of aging of multicellular organisms. The cells of multicellular organisms, in contrast to unicellular organisms, are burdened with a two- part genome: housekeeping and specialized (multicellular), responsible for ontogenesis and terminal differentiation. The two parts of the…
Matthew J. Baker, Joyce P. Jacobsen
We discuss the interrelationship between the treatment of the elderly, the nature of production, and the transmission of culture. Respect for the elderly is endogenous. Parents cultivate an interest in consuming culture in their children; when they are older, children compensate their elders proportional to the degree…
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Many theories have been proposed for answering two questions on aging: "Why do we age?" and "How do we age?" But which ones of them are finally tenable? We have made an analysis of these theories to select out the useful ones. Evolutionary theories are made for interpreting the evolutionary advantage of aging, and…
Authors not listed
Aging is a natural process that is also influenced by some factors like food someone eats, lifestyle decisions, and impacts on general health. Despite the recognized role of nutrition in modulating the molecular and cellular mechanisms underlying aging, there is a lack of comprehensive exploration into potential…
James Swift, Matthew Arran Turner, James Christopher Reynolds
A rapid headspace analysis method for the authenticity testing of whiskies of different brands and years was developed for a low cost, deployable atmospheric pressure ionisation mass spectrometer, which required minimal sample preparation. Principal component analysis was applied to the time-averaged mass spectra, the…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in brain, along with neuroinflammation and synaptic dysfunction. Genetic…