25 papers · ranked by Valyu relevance
Rumiana Tenchov, Janet M. Sasso, Xinmei Wang, Qiongqiong Angela Zhou
and Progression and Age-Related Diseases: A Landscape View of Research Advancement Authors: ['Rumiana Tenchov' 'Janet M. Sasso' 'Xinmei Wang' 'Qiongqiong Angela Zhou'] Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Tamas Fulop, Anis Larbi, Abdelouahed Khalil, Alan A. Cohen + 1 more
'Jacek M. Witkowski'] Growing elderly populations, sometimes referred to as gray (or silver) tsunami, are an increasingly serious health and socioeconomic concern for modern societies. Science has made tremendous progress in the understanding of aging itself, which has helped medicine to extend life expectancies. With…
Hema Sharma Datta, S. K. Mitra, Rangesh Paramesh, Bhushan Patwardhan
Aging is a complex phenomenon, a sum total of changes that occur in a living organism with the passage of time and lead to decreasing ability to survive stress, increasing functional impairment and growing probability of death. There are many theories of aging and skin remains the largest organ of the study. Skin aging…
Leonard Hayflick
Age changes can occur in only two fundamental ways: by a purposeful program driven by genes or by random, accidental events. It is a cornerstone of modern biology that a purposeful genetic program drives all biological processes that occur from the beginning of life to reproductive maturation. However, once…
David Gems
From a biological perspective aging (senescence) appears to be a form of complex disease syndrome, though this is not the traditional view. This essay aims to foster a realistic understanding of aging by scrutinizing ideas old and new. The conceptual division between aging-related diseases and an underlying…
Alexander Muacevic, John R Adler, Víctor Manuel Mendoza-Núñez, Ana Belén Mendoza-Soto
'Ana Belén Mendoza-Soto'] Ageism is a type of discrimination characterized by negative social representations of old age and aging, with prejudices and stereotypes that cause rejection and marginalization of older adults, generally considering them as fragile and unproductive. For this reason, it is recognized as one…
Yin Wang, Tao Huang, Xianzheng Sha, Yixue Li + 1 more
Aging is a fundamental biological process, where key bio-markers interact with each other and synergistically regulate the aging process. Thus aging dysfunction will induce many disorders. Finding aging markers and re-constructing networks based on multi-omics data (i.e. methylation, transcriptional and so on) are…
Kamarul Ariffin Khalid, Ahmad Faris Mohd Nawi, Nuraqilah Zulkifli, Md. Abul Barkat + 2 more
'Md. Abul Barkat' 'Hazrina Hadi' 'Enzo Berardesca'] Aging is a universal process that can cause diminished function of organs and various diseases. The most striking consequences of aging can be seen visibly on the skin, which acts as a barrier against various external insults. Aging of the skin consists of intrinsic…
Authors not listed
A steep, age‑related drop in nicotinamide adenine dinucleotide (NAD+) now ranks among the most reproducible molecular signatures of human aging, driving metabolic slowdown, mitochondrial dysfunction, DNA‑repair deficits, chronic inflammation, and stem‑cell fatigue. Boost NAD+ for Anti‑Aging: A Multidimensional Review…
Silvio Cabral Patricio
Human aging is marked by a steady rise in mortality risk with age — a process demographers describe as senescence. While life expectancy has improved dramatically over the past century, a fundamental question remains: is the rate at which mortality accelerates biologically fixed, or has it shifted across generations?…
Timothy V. Pyrkov, Konstantin Avchaciov, Andrei E. Tarkhov, Leonid I. Menshikov + 2 more
We analyzed aging trajectories of complete blood counts (CBC) and their association with the incidence of chronic diseases and death in cohorts of aging individuals registered in the UK Biobank and National Health and Nutrition Examination Survey (NHANES) studies. Application of a proportional hazards model to the CBC…
Andrey V. Kuznetsov
This study proposes using accumulated neurotoxicity, defined as the time integral of Aβ oligomer concentration, as a biomarker for neuronal aging. A relationship between biological age and accumulated neurotoxicity is proposed. Numerical analysis guided the development of a new analytical solution linking the…
Andrey V. Kuznetsov
This study proposes using accumulated neurotoxicity, defined as the time integral of Aβ oligomer concentration, as a biomarker for neuronal aging. A relationship between biological age and accumulated neurotoxicity is proposed. Numerical analysis guided the development of a new analytical solution linking the…
Richard Y. Chin
The teleology of aging has been one of the more vexing and controversial question in biology. One potential evolutionary driver of programmed aging is selection pressure from parasites and other infectious organisms. While selection pressure from parasites and other infectious organisms have long been considered by…
Hong Qin
Systems Authors: ['Hong Qin'] Based on the study of cellular aging using the single cell model organism of budding yeast and corroborated by other studies, we propose the Emergent Aging Model (EAM). EAM hypothesizes that aging is an emergent property of complex biological systems, exemplified by biological networks…
Alex Zhavoronkov, Bhupinder Bhullar
Aging is a complex continuous multifactorial process leading to loss of function and crystalizing into the many age-related diseases. Here, we explore the arguments for classifying aging as a disease in the context of the upcoming World Health Organization’s 11th International Statistical Classification of Diseases and…
Authors not listed
Aging is a natural process that is also influenced by some factors like food someone eats, lifestyle decisions, and impacts on general health. Despite the recognized role of nutrition in modulating the molecular and cellular mechanisms underlying aging, there is a lack of comprehensive exploration into potential…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in brain, along with neuroinflammation and synaptic dysfunction. Genetic…
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Many theories have been proposed for answering two questions on aging: "Why do we age?" and "How do we age?" But which ones of them are finally tenable? We have made an analysis of these theories to select out the useful ones. Evolutionary theories are made for interpreting the evolutionary advantage of aging, and…
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Aging changes including age spots and atherosclerotic plaques develop in an inhomogeneous and accelerated manner. For understanding this phenomenon, some aging changes are analyzed by Misrepair mechanism, a mechanism proposed in Misrepair-accumulation theory. I. Misrepair is a strategy of repair for survival of an…
André C. R. Martins
The question of why we age is a fundamental one. It is about who we are, and it also might have critical practical aspects as we try to find ways to age slower. Or to not age at all. Different reasons point at distinct strategies for the research of anti-ageing drugs. While the main reason why biological systems work…
Matthew J. Baker, Joyce P. Jacobsen
We discuss the interrelationship between the treatment of the elderly, the nature of production, and the transmission of culture. Respect for the elderly is endogenous. Parents cultivate an interest in consuming culture in their children; when they are older, children compensate their elders proportional to the degree…
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Hutchinson–Gilford Progeria syndrome, Werner syndrome, and Cockayne syndrome are three genetic disorders, in which the children have premature aging features. To understand the phenomenon of premature aging, the similarity of aging features in these syndromes to that in normal aging is investigated. Although these…
Authors not listed
Protein aggregation is a hallmark of molecular aging and is implicated in various neurodegenerative diseases. Aggregation proceeds via autocatalytic, thermodynamically favored pathways. Yet in living systems, dynamic, active regulation and compartmentalization—such as in biomolecular condensates—can suppress or delay…