27 papers · ranked by Valyu relevance
Rumiana Tenchov, Janet M. Sasso, Xinmei Wang, Qiongqiong Angela Zhou
and Progression and Age-Related Diseases: A Landscape View of Research Advancement Authors: ['Rumiana Tenchov' 'Janet M. Sasso' 'Xinmei Wang' 'Qiongqiong Angela Zhou'] Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Sergiy Libert, Alex Chekholko, Cynthia Kenyon
Why people age at different rates is a fundamental, unsolved problem in biology. We created a model that predicts an individual’s age from physiological traits that change with age in the large UK Biobank dataset, such as blood pressure, lung function, strength and stimulus-reaction time. The model best predicted a…
Bruno César Feltes
The question of whether aging should be classified as a disease has gained prominence in geroscience, fueled by advances in molecular biology and the aspiration to develop interventions that mitigate age-associated functional decline. However, evolutionary models describe aging as an emergent consequence of declining…
Alexander Muacevic, John R Adler, Víctor Manuel Mendoza-Núñez, Ana Belén Mendoza-Soto
'Ana Belén Mendoza-Soto'] Ageism is a type of discrimination characterized by negative social representations of old age and aging, with prejudices and stereotypes that cause rejection and marginalization of older adults, generally considering them as fragile and unproductive. For this reason, it is recognized as one…
Shinichi Noto, Manoj Sharma
The aging of the world’s population and the health problems accompanying it are becoming increasingly severe. Healthcare policies in developed countries focus on how to prevent and treat diseases associated with aging and how to maintain quality of life. Typical age-related diseases include deafness, cataracts…
Reuben Ng, Nicole Indran, Andrea Gilmore-Bykovskyi
Aging is a natural phase of life. However, the meanings ascribed to it are highly subjective, making attitudes toward growing older diverse and complex (; ). Both positive and negative views of later life exist. On the positive side, later life is often celebrated as a time of fulfillment (; ), increased well-being ()…
Axel Kowald, Thomas B L Kirkwood
Human life expectancy has increased dramatically over the past two centuries, marking a significant public health achievement. While some projections predict a future where median lifespans reach 100 years, others contend that further longevity will depend on breakthroughs targeting the biological processes of aging.…
Kamarul Ariffin Khalid, Ahmad Faris Mohd Nawi, Nuraqilah Zulkifli, Md. Abul Barkat + 2 more
'Md. Abul Barkat' 'Hazrina Hadi' 'Enzo Berardesca'] Aging is a universal process that can cause diminished function of organs and various diseases. The most striking consequences of aging can be seen visibly on the skin, which acts as a barrier against various external insults. Aging of the skin consists of intrinsic…
Authors not listed
A steep, age‑related drop in nicotinamide adenine dinucleotide (NAD+) now ranks among the most reproducible molecular signatures of human aging, driving metabolic slowdown, mitochondrial dysfunction, DNA‑repair deficits, chronic inflammation, and stem‑cell fatigue. Boost NAD+ for Anti‑Aging: A Multidimensional Review…
Silvio Cabral Patricio
Human aging is marked by a steady rise in mortality risk with age — a process demographers describe as senescence. While life expectancy has improved dramatically over the past century, a fundamental question remains: is the rate at which mortality accelerates biologically fixed, or has it shifted across generations?…
Alison Ziesel, Jennifer Reeves, Anastasia Mallidou, Lorelei Newton + 4 more
Biological aging is a rapidly growing area of research, which entails characterizing the rate of aging independent of an individual’s chronological age. In this review, we analyze the results of biological aging research in 435 papers published in a twelve year window, revealing changing patterns of molecular markers…
Andrey V. Kuznetsov
This study proposes using accumulated neurotoxicity, defined as the time integral of Aβ oligomer concentration, as a biomarker for neuronal aging. A relationship between biological age and accumulated neurotoxicity is proposed. Numerical analysis guided the development of a new analytical solution linking the…
Muhammad Ali, Fei Li, Manpreet Katari
Identifying the set of genes that regulate baseline healthy aging – aging that is not confounded by illness – is critical to understating aging biology. Machine learning-based age-estimators (such as epigenetic clocks) offer a robust method for capturing biomarkers that strongly correlate with age. In principle, we can…
Andrey V. Kuznetsov
This study proposes using accumulated neurotoxicity, defined as the time integral of Aβ oligomer concentration, as a biomarker for neuronal aging. A relationship between biological age and accumulated neurotoxicity is proposed. Numerical analysis guided the development of a new analytical solution linking the…
Hong Qin
Systems Authors: ['Hong Qin'] Based on the study of cellular aging using the single cell model organism of budding yeast and corroborated by other studies, we propose the Emergent Aging Model (EAM). EAM hypothesizes that aging is an emergent property of complex biological systems, exemplified by biological networks…
Jacques Demongeot, Pierre Magal
The chronological age used in demography describes the linear evolution of the life of a living being. The chronological age cannot give precise information about the exact developmental stage or aging processes an organism has reached. On the contrary, the biological age (or epigenetic age) represents the true…
Alexey Kondyurin
Theory of aging based on the kinetics of chemical reactions and the rules of natural selection of organisms is proposed. Biochemical processes in organism can be described in terms of chemical reaction kinetics. The evolutionary process of organisms is determined by the goal of continuing life, and the natural…
Francesco Mattace-Raso
Aging is the most impressive demographic phenomenon in human history. Due to fast medical developments, in addition to developments in the fields of transport, communication and economics, the world’s population is aging progressively and globally. Humans have always reached extreme ages; it is not uncommon for…
Authors not listed
Aging is a natural process that is also influenced by some factors like food someone eats, lifestyle decisions, and impacts on general health. Despite the recognized role of nutrition in modulating the molecular and cellular mechanisms underlying aging, there is a lack of comprehensive exploration into potential…
Samir Aisin, Boris V. Lidskii, Peter V Lidsky
The biological feasibility of human rejuvenation remains a subject of intense debate, yet answering this question is critical for guiding research strategies. Should aging research focus on reversing aging in older individuals, or on pausing its progression at earlier ages? We address this question with evolutionary…
Shuchao Yang, Daoshun Ge
Aging anxiety constitutes a pressing practical issue impacting active aging and healthy aging of the population. Existing theories on aging anxiety predominantly analyze its intrinsic causes through psychosocial perspectives such as perception and identity formation, yet insufficient attention has been paid to…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in brain, along with neuroinflammation and synaptic dysfunction. Genetic…
Matthew J. Baker, Joyce P. Jacobsen
We discuss the interrelationship between the treatment of the elderly, the nature of production, and the transmission of culture. Respect for the elderly is endogenous. Parents cultivate an interest in consuming culture in their children; when they are older, children compensate their elders proportional to the degree…
Glen Pridham, Kenneth Rockwood, Andrew D. Rutenberg
tipping point near age 75 Authors: ['Glen Pridham' 'Kenneth Rockwood' 'Andrew D. Rutenberg'] The frailty index (FI) serves as a useful quantitative summary of age-related health. We quantitatively modelled FI trajectories with age. We fit directly to longitudinal transitions in health attributes from normal to deficit…
Jiajun Ma, Qinghua Chen, Xiaosong Chen, Jingfang Fan + 2 more
structure in 200 countries Authors: ['Jiajun Ma' 'Qinghua Chen' 'Xiaosong Chen' 'Jingfang Fan' 'Xiaomeng Li' 'Yi Shi'] Ignoring the differences between countries, human reproductive and dispersal behaviors can be described by some standardized models, so whether there is a universal law of population growth hidden in…
Authors not listed
Protein aggregation is a hallmark of molecular aging and is implicated in various neurodegenerative diseases. Aggregation proceeds via autocatalytic, thermodynamically favored pathways. Yet in living systems, dynamic, active regulation and compartmentalization—such as in biomolecular condensates—can suppress or delay…