25 papers · ranked by Valyu relevance
Babak Tavana, Aicheng Chen, Mourad N. El-Gamal, Mohannad Y. Elsayed
All pharmaceutical drugs, vaccines, cosmetic products, and many medical breakthroughs must first be approved through clinical research and trials before advancing to standard practice or entering the marketplace. Clinical trials are sets of tests that are required to determine the safety and efficacy of pharmaceutical…
Huangxian Ju, Serge Cosnier
1## Introduction Analytical chemistry is a measurement science that provides data on the chemical composition, structure, and concentrations of substances, their spatiotemporal distribution, and their interactions in different states, including evolutionary information. The discipline aims to propose new measurement…
Huangxian Ju
Analytical chemistry is a measuring science to probe the compositions and structures of matters, study the chemical constituents, contents, distribution, and interaction of matters, and reveal the space-time rules of matter changes. As the eyes of fundamental scientific research and social activities relative to human…
Matthew Lewis, Elena Chekmeneva, Stephane Camuzeaux, Caroline Sands + 11 more
Metabolomics utilising liquid chromatography mass spectrometry (LC-MS) offers biomedical researchers a powerful means of assessing and comparing human phenotypes via measurement of the metabolome in biological samples. Platforms for LC-MS-based global profiling quantify hundreds or thousands of small molecule…
Chaitanya Gupta, Kishan Aryasomayajula, Sean R. Fischer, Zheng Jia + 7 more
Analytical chemistry provides the content of nearly every scientific, technical and business decision relating to what atoms, molecules and devices are and how they interact in their environment. Various workflows come together in describing those interactions--separation, identification, quantitation…
Jake A. Carter, Ariane I. Barros, Joaquim A. Nóbrega, George L. Donati
'George L. Donati'] Applications, advantages, and limitations of the traditional external standard calibration, matrix-matched calibration, internal standardization, and standard additions, as well as the non-traditional interference standard method, standard dilution analysis, multi-isotope calibration, and…
Steffen Uhlig, Kapil Nichani, Manfred Stoyke, Petra Gowik
Non-targeted methods (NTMs) are being increasingly developed and adopted to detect food fraud and identify the authenticity of the food. Method validation is a critical step before bringing the NTMs to the routine to be assured of method performance and trust that its outcomes are reliable. However, the paucity of well…
Davide Ciccarelli, Tim Marczylo, Paolo Vineis, Leon Barron
A novel and generalisable analytical workflow for non-target analysis (NTA) and suspect screening (SS) of potentially toxic organic acids in drinking water is presented, featuring selective extraction by silica-based strong anion exchange solid-phase extraction (SAX-SPE), mixed-mode liquid chromatography-high…
Carl‐Fredrik Mandenius
This minireview suggests a conceptual and user-oriented approach for the design of process monitoring systems in bioprocessing. Advancement of process analytical techniques for quantification of critical analytes can take advantage of basic conceptual process design to support reasoning, reconsidering and ranking…
Filipe Monteiro-Silva, Gerardo González-Aguilar
Pyrrolizidine Alkaloids (PAs) are a group of naturally occurring alkaloids that are produced by plants as a defense mechanism against insect herbivores. The analytical methodologies employed for their detection have come a long way since the first analytical experiment and in the last 30 years had an enormous…
Huanhuan Hong, Ahsan Habib, Lei Bi, Deepro Qais + 1 more
Mass spectrometry (MS) has become an essential analytical method in every sector of science and technology. Because of its unique ability to provide direct molecular structure information on analytes, an extra method is rarely required. This review describes fabrication of a variable-pressure hollow cathode discharge…
Renato S. Lima, Leandro Y. Shiroma, Álvaro Vianna Novaes de Carvalho Teixeira, José Roberto de Toledo + 5 more
'Álvaro Vianna Novaes de Carvalho Teixeira' 'José Roberto de Toledo' 'Bruno C. Couto' 'Rogério M. Carvalho' 'Emanuel Carrilho' 'Lauro T. Kubota' 'Ângelo L. Gobbi'] ABSTRACT: We address a novel method for analytical determinations that combines simplicity, rapidity, low consumption of chemicals, and portability with…
D. S. Leonard, D. J. Auty, T. Didberidze, R. Gornea + 97 more
'Patrícia Grinberg' 'R. MacLellan' 'Brad Methven' 'A. Piepke' 'J.-L. Vuilleumier' 'J. B. Albert' 'G. Anton' 'I. Badhrees' 'P. S. Barbeau' 'Reimund Bayerlein' 'D. Beck' 'V. Belov' 'M. Breidenbach' 'T. Brunner' 'G. F. Cao' 'W. R. Cen' 'C. Chambers' 'B. T. Cleveland' 'Minor J. Coon' 'A. Craycraft' 'W. Cree' 'T. Daniels'…
L. L. Lamparski, T. J. Nestrick
The analytical chemist involved in industrial trace analysis is frequently confronted with many varied problems. Programs to produce acceptable data can be divided into two classes depending upon the level of quality assurance that is required. Frequently, unvalidated analytical procedures can be used to generate data…
Siarhei Charapitsa, S. Sytova, Andrey A. Makhomet, T.I. Guguchkina + 3 more
'Mikhail Markovsky' 'Yurii F. Yakuba' 'Yurii N. Kotov'] b Federal State Budgetary Scientific Institution North Caucasian Regional Research Institute of Horticulture and Viticulture, 40 Let Pobedy Str., 39, Krasnodar 350901, Russia c Branch of Joint Stock Company "Rosspirtprom" Wine and Distillery Plant "Cheboksary"…
Xuanwen Li, Nicholas A. Pierson, Xiaoqing Hua, Bhumit A. Patel + 4 more
The use of Multi-attribute method (MAM) for identity and purity testing of biopharmaceuticals offers the ability to complement and replace multiple conventional analytical technologies with a single mass spectrometry (MS) method. Method qualification and phase-appropriate validation is one major consideration for the…
Phyllis A. Rees, R. Joel Lowy
Western blot (WB) analysis is widely used, but obtaining consistent results can be problematic, particularly if all the treatments cannot be placed on one gel. Sources of variation were investigated by analyzing a set of samples which should produce statistically identical results, an approach commonly applied to…
Yuanjun Xu, An Zhu, Ning Huang, Peng Wang + 2 more
This paper introduces the necessity and significance of the investigation of cultural heritage objects. The multi-technique method is useful for the study of cultural heritage objects, but a comprehensive analytical instrument is a better choice since it can guarantee that different types of information are always…
Marek Wesolowski, Kyriakos Kachrimanis
Background/Objectives: Drug products on the pharmaceutical market must meet a number of requirements that guarantee their quality, safety, and efficacy. Accordingly, periodic inspection of the content of active pharmaceutical ingredients (APIs) in marketed drug products is carried out, confirming that they meet all…
Yasutaka Kitahama, Pablo Martínez Pancorbo, Hiroki Segawa, Machiko Marumi + 4 more
'Machiko Marumi' 'Ting‐Hui Xiao' 'K. Hiramatsu' 'William Yang' 'Keisuke Goda'] - a Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan. E-mail: goda@chem.s.utokyo.ac.jp - b LucasLand, Co. Ltd, Tokyo 101-0052, Japan - c Third Department of Forensic Science, National Research Institute of Police…
Jatin Nandania, Gopal Peddinti, Alberto Pessia, Meri Kokkonen + 1 more
The use of metabolomics profiling to understand metabolism under different physiological states has increased in recent years, which created the need for robust analytical platforms. Here, we present a validated method for targeted and semi-quantitative analysis of 102 polar metabolites that covers major metabolic…
Juan Allegretto, Jakub Dostalek
Volatile Organic Compounds (VOCs) represent health and environmental hazardous compounds but also play crucial roles in other fields including early disease diagnostics and organoleptic perception of aliments important in food production. Accurate VOCs analysis is essential, and require innovative analytical methods…
Igor Kaltashov, Kenyon Kowalski, Ryan Sullivan, Alyssa Marsico + 1 more
Forensics has long been viewed by chemical educators as a field with great potential as far as providing inspiration for modifying chemistry laboratory curriculum and enhancing students’ learning experience at different levels. While most experiments are based on adaptation of laboratory procedures routinely used in…
Brianna M. Garcia, Goncalo J. Gouveia, Amanda O. Shaver, Ricardo M. Borges + 3 more
Metabolomics commonly uses analytical techniques such as nuclear magnetic resonance (NMR) and liquid chromatography coupled to mass spectrometry (LC-MS) to quantify and identify metabolites associated with biological variation. Metabolome coverage from untargeted LC-MS studies relies heavily on the pre-analytical…
José Camacho, Jokin Ezenarro, Daniel Schorn-García, Johan A. Westerhuis
ANOVA Simultaneous Component Analysis (ASCA) is the current state-of-theart chemometric tool for analyzing and interpreting high-dimensional experimental data from a Design of Experiment (DoE). Being a multivariate extension of the ANOVA, ASCA makes a perfect tandem with DoE. This tutorial review recommends best…