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27 papers · ranked by Valyu relevance
Sixuan Chen, Liping Tu, Quanhua Chen
The field of spatial pharmacology has emerged as a critical framework for understanding the complex interactions between anti-cancer immunomodulators, tumor cells, and the tumor microenvironment (TME) at single-cell resolution. This review synthesizes the theoretical foundations, historical evolution, clinical…
Shaoming Zhu, Tian Zhang, Lei Zheng, Hongtao Liu + 4 more
'Delong Liu' 'Zihai Li' 'Chong-xian Pan'] Immunotherapies such as immune checkpoint blockade (ICB) and adoptive cell therapy (ACT) have revolutionized cancer treatment, especially in patients whose disease was otherwise considered incurable. However, primary and secondary resistance to single agent immunotherapy often…
Lekshmi R. Nath, Gautam Sethi, Vijayasteltar B. Liju
Cancer remains a major global health challenge, reinforcing the need for innovative therapeutic strategies to achieve better outcomes. Despite existing traditional therapies such as radiation therapy, chemotherapy, and photodynamic therapy, cancer mortality rates continue to rise each year. Recently, immunotherapy has…
Hamdoon A. Mohammed, Abdul-Hamid Emwas, Riaz A. Khan, Shivraj Hariram Nile + 1 more
'Shivraj Hariram Nile' 'Doo Hwan Kim'] Halophytes and xerophytes, plants with adequate tolerance to high salinity with strong ability to survive in drought ecosystem, have been recognized for their nutritional and medicinal values owing to their comparatively higher productions of secondary metabolites, primarily the…
Ruchi Roy, Sunil Kumar Singh, Sweta Misra, Fabio Grizzi
Recent work has suggested involvement of the immune system in biological therapies specifically targeting tumor microenvironment. Substantial advancement in the treatment of malignant tumors utilizing immune cells, most importantly T cells that play a key role in cell-mediated immunity, have led to success in clinical…
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin + 4 more
Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood. Early immune checkpoint inhibitors have delivered significant clinical benefit, but their efficacy and durability remain limited in many patients.…
Richard J Beck, Bettina Weigelin, Joost B Beltman
Several immunotherapeutic strategies for the treatment of cancer are under development. Two prominent strategies are adoptive cell transfer (ACT) of cytotoxic T lymphocytes (CTLs) and modulation of CTL function with immune checkpoint inhibitors or with costimulatory antibodies. Despite some success with these…
Kavita Iyer, Julian Ivanov, Rumiana Tenchov, Krittika Ralhan + 4 more
Rapid and sustained growth in the field of immuno-oncology has resulted in expansion of available scientific literature. Gaining valuable insights and establishing deep and often hidden meaningful connections in such a large body of work is the need of the hour. In this report we summarize our findings from a novel…
Sawsan Sudqi Said, Wisam Nabeel Ibrahim, Maria Teresa Cruz, Gabriele Grassi
Cancer immunotherapy is a type of treatment that harnesses the power of the immune systems of patients to target cancer cells with better precision compared to traditional chemotherapy. Several lines of treatment have been approved by the US Food and Drug Administration (FDA) and have led to remarkable success in the…
Alaina C. Larson, Kenadie R. Doty, Joyce C. Solheim
Although the development of immunotherapies has been revolutionary in the treatment of several cancers, many cancer types remain unresponsive to immune-based treatment and are largely managed by chemotherapy drugs. However, chemotherapeutics are not infallible and are frequently rendered ineffective as resistance…
Darawan Rinchai, Elena Verzoni, Veronica Huber, Agata Cova + 14 more
Anti-angiogenic tyrosine-kinase inhibitors (TKIs) and immune checkpoint blockade (ICB) constitute the backbone of metastatic renal cell carcinoma (mRCC) treatment. The development of the optimal combinatorial or sequential approach is hindered by the lack of comprehensive data regarding TKI-induced immunomodulation and…
Li, Chenghang, Lei, Jinzhi
Mathematical oncology is a rapidly evolving interdisciplinary field that uses mathematical models to enhance our understanding of cancer dynamics, including tumor growth, metastasis, and treatment response. Tumorimmune interactions play a crucial role in cancer biology, influencing tumor progression and the…
Wan-Chung Hu
Cancer immunotherapy is a promising new approach for cancer treatment. We propose to use a new host immunological pathway: THαβ immunity for cancer treatment. THαβ immunity is a natural host immunity which can be used IFN-α/β and its major effectors are IL-10 and IL-15. Thus, we here used these cytokines for treatment…
Authors not listed
Immuno-oncology, a rapidly evolving field at the forefront of cancer research, leverages the body’s immune system to fight cancer. In this follow up report, we extend our natural language processing (NLP)-based analysis to pinpoint the context of emergence of the previously identified emerging concepts. To achieve this…
C. Demerle, L. Gorvel, M. Mello, S. Pastor + 11 more
TNFRF-14/HVEM is the ligand for BTLA and CD160 negative immune co-signaling molecules as well as viral proteins. Its expression is dysregulated with an overexpression in tumors and a connection with tumors of adverse prognosis. We developed C57BL/6 mouse models co-expressing human huBTLA and huHVEM as well as…
Collin Y. Zheng, Peter Kim
We introduce a set of ordinary differential equations (ODE) that qualitatively reproduces delayed responses observed in immune checkpoint blockade therapy (e.g. anti-CTLA-4 Ipilimumab). This type of immunotherapy has been at the forefront of novel and promising cancer treatments over the past decade and was recognised…
Kamran Kaveh, Feng Fu
Immune checkpoint therapy is one of the most promising immunotherapeutic methods that are likely able to give rise to durable treatment response for various cancer types. Despite much progress in the past decade, there are still critical open questions with particular regards to quantifying and predicting the efficacy…
Manish Kumar
Cancer is a complex disease having a number of composite problems to be considered including cancer immune evasion, therapy resistance, and recurrence for a cure. Fundamentally, it remains a genetic disease as diverse aspects of the complexity of tumor growth and cancer development relate to its genetic machinery and…
E. Amit Romach, M. Nachliely, O. Moran, M. Brami + 1 more
The use of Psychedelics by patients with cancer to relieve anxiety and depression has increased in the past few years. Since Psychedelics have immunomodulatory effects, their consumption among cancer patients should be carefully considered due to their potential negative effects on the tumor immune stroma, especially…
Vasiliki Bitsouni, Vasilis Tsilidis
tBregs are a newly discovered subcategory of B regulatory cells, which are generated by breast cancer, resulting in the increase of Tregs and therefore in the death of NK cells. In this study, we use a mathematical and computational approach to investigate the complex interactions between the aforementioned cells as…
Chenghang Li, Haifeng Zhang, Xiulan Lai, Jinzhi Lei
The tumor-immune system plays a critical role in colorectal cancer progression. Recent preclinical and clinical studies showed that combination therapy with anti-PD-L1 and cancer vaccines improved treatment response. In this study, we developed a multiscale mathematical model of interactions among tumors, immune cells…
Cristina Martínez-Hernández, Mariana del Carmen Aguilera-Puga, Fabien Plisson
Current cancer treatments damage healthy cells and tissues, causing short-term and long-term side effects. New treatments are desired that show greater selectivity toward cancer cells and evade the common mechanisms of multidrug resistance. Membranolytic anticancer peptides (mACPs) hold promise against cancer and…
Ganapathy Sriram, Lauren Milling, Jung-Kuei Chen, Wuhbet Abraham + 3 more
Inhibition of immune checkpoints has shown promising results in the treatment of certain tumor types. However, the majority of cancers do not respond to immune checkpoint inhibition (ICI) treatment, indicating the need to identify additional modalities that enhance the response to immune checkpoint blockade. In this…
Authors not listed
Hodgkin’s lymphoma is a malignancy (cancer) that affects the immune system, primarily lymphocytes (white blood cells). CD30 is a protein receptor expressed on the surface of Hodgkin's cancer cells and is a crucial target for diagnosis and treatment. As of now, current CD30-targeted therapies come with extensive side…
Aman Chandra Kaushik, Mengyang Li, Dong-Qing Wei
The Anti-cancer targets play crucial role in signalling processes of cells. We have developed an Anti-Cancer Scanner (ACS) tool for identification of Anti-cancer targets in form of peptides. ACS tool also allows fast fingerprinting of the Anti-cancer targets of significance in the current bioinformatics research. There…
Tibor Bakács, Katalin Kristóf, J.N. Mehrishi, Tamás Szabados + 3 more
'Csaba Kerepesi' 'Enikoe Regoes' 'Gábor Tusnády'] 1Department of Probability, Alfred Renyi Institute of Mathematics, The Hungarian Academy of Sciences, 1053 Budapest, Reáltanoda str. 13-15. Hungary; 2Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Robert-Koch-Str. 40…
Arpana Parihar, Nidhi Puranik, Rekha Khandia, Raju Khan
Background: Cancer is a prominent cause of disease burden all over the world. Primary cause of the development of cancer is exposure to potentially hazardous environmental factors and unhealthy lifestyle. Among all types of cancer, breast cancer is most common in women and becomes a public health issue on a global…