26 papers · ranked by Valyu relevance
Luca Falzone, Salvatore Salomone, Massimo Libra
The medical history of cancer began millennia ago. Historical findings of patients with cancer date back to ancient Egyptian and Greek civilizations, where this disease was predominantly treated with radical surgery and cautery that were often ineffective, leading to the death of patients. Over the centuries, important…
Sukhdev Singh, Bhupender Sharma, Shamsher S. Kanwar, Ashok Kumar
Cancer is a serious concern at present. A large number of patients die each year due to cancer illnesses in spite of several interventions available. Development of an effective and side effects lacking anticancer therapy is the trending research direction in healthcare pharmacy. Chemical entities present in plants…
Yuan Gao, Qingyao Shang, Wenyu Li, Wenxuan Guo + 4 more
'Alexander Stojadinovic' 'Ciaran Mannion' 'Yan-gao Man' 'Tingtao Chen'] Various antibiotics have been used in the treatment of cancers, via their anti-proliferative, pro-apoptotic and anti-epithelial-mesenchymal-transition (EMT) capabilities. However, increasingly studies have indicated that antibiotics may also induce…
Cristina Martínez-Hernández, Mariana del Carmen Aguilera-Puga, Fabien Plisson
Current cancer treatments damage healthy cells and tissues, causing short-term and long-term side effects. New treatments are desired that show greater selectivity toward cancer cells and evade the common mechanisms of multidrug resistance. Membranolytic anticancer peptides (mACPs) hold promise against cancer and…
Sarad Pawar Naik Bukke, Balakrishna Vuyyala, Chandrashekar Thalluri, Ananda Kumar Chettupalli + 9 more
Genetic or epigenetic changes that lead to abnormal development of signalling through cellular pathways such as MAPK, PI3K/AKT/mTOR, Wnt/β-catenin play an important role in driving cancer. These signalling pathways control how cells grow, divide and die (apoptosis). Thus, the continued activation of these pathways…
Youssef T. Abdou, Sheri M. Saleeb, Khaled M. A. Abdel-Raouf, Mohamed Allam + 2 more
Peptide-based drugs have emerged as highly selective and potent cancer therapy. Cancer is one of the leading causes of death worldwide. Multiple approaches have been developed towards cancer treatment, including chemotherapy, radiation, and hormonal therapy; however, such procedures’ non-specificity, toxicity, and…
Marcos Vilariño, Josune García-Sanmartín, Laura Ochoa-Callejero, Alberto López-Rodríguez + 2 more
Mushrooms have been used for millennia as cancer remedies. Our goal was to screen several species from the rain forest of Costa Rica looking for new antitumor molecules. Mushroom extracts were screened using two human cell lines: A549 (lung adenocarcinoma) and NL20 (immortalized normal lung epithelium). Extracts able…
Idowu Jonas Sagbo, Wilfred Otang-Mbeng, Silvie Rimpelová
Cancer occurrence is rapidly increasing all over the world, including in developing countries. The current trend in cancer management requires the use of herbal remedies since the majority of anticancer drugs are known to be costly, with unwanted side effects. In the Eastern Cape province, the use of medicinal plants…
Katarzyna Gach-Janczak, Joanna Drogosz-Stachowicz, Anna Janecka, Karol Wtorek + 2 more
'Karol Wtorek' 'Marek Mirowski' 'Robert Kleszcz'] Simple Summary Cancer is one of the leading causes of death worldwide. Among several therapeutic options available for patients, chemotherapy remains the most often used treatment strategy. Anticancer drugs known today are either substances isolated from plants and…
Aman Chandra Kaushik, Mengyang Li, Dong-Qing Wei
The Anti-cancer targets play crucial role in signalling processes of cells. We have developed an Anti-Cancer Scanner (ACS) tool for identification of Anti-cancer targets in form of peptides. ACS tool also allows fast fingerprinting of the Anti-cancer targets of significance in the current bioinformatics research. There…
Jannis Born, Matteo Manica, Ali Oskooei, Joris Cadow + 1 more
'María Rodríguez Martínez'] With the advent of deep generative models in computational chemistry, in silico drug design has undergone an unprecedented transformation. While state-of-the-art deep learning approaches have shown potential in generating compounds with desired chemical properties, they disregard the…
Enrico Catalano
Phytochemicals are plant-derived secondary metabolites, which may exert many biological activities in humans, including anticancer properties. Although recent findings appear to support their role in cancer prevention and treatment, this issue is still controversial. Anti-cancer activity of phytochemicals mainly…
Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Elena Bustamante Munguira, Celia Andrés Juan + 2 more
Simple Summary Conventional cancer treatments, based on chemotherapy and radiotherapy, are often effective but suffer from serious side effects and a potential risk of resistance. Dual therapies, combining DNA alkylating agents and antimicrobial peptides, are generating great interest. Within chemotherapies, a…
Justin Riley Y. Lam, Guinevere A. Casimpan, Christine May L. Batoy, Ma. Felaine Cebedo + 11 more
Antimitotic Activity of Samanea saman Leaf Extract in the In Vitro Development of Tripneustes gratilla Embryo Commercially available anticancer drugs are expensive and may have side effects. This led the researchers to look into alternative plant sources. One of these is acacia or S. saman. To determine whether S.…
Onur Karakaya, Zeynep Hilal Kilimci
Anticancer peptides (ACPs) are a group of peptides that exhibite antineoplastic properties. The utilization of ACPs in cancer prevention can present a viable substitute for conventional cancer therapeutics, as they possess a higher degree of selectivity and safety. Recent scientific advancements generate an interest in…
Raúl Isea, Johan Hoebeke, Rafael Mayo, Fernando Alvarez + 1 more
'David S. Holmes'] Cancer is a disease involving many genes, consequently it has been difficult to design anticancer drugs that are efficacious over a broad range of cancers. The robustness of cellular responses to gene knockout and the need to reduce undesirable side effects also contribute to the problem of effective…
Manish Kumar
Cancer is a complex disease having a number of composite problems to be considered including cancer immune evasion, therapy resistance, and recurrence for a cure. Fundamentally, it remains a genetic disease as diverse aspects of the complexity of tumor growth and cancer development relate to its genetic machinery and…
Authors not listed
Dysregulation of transmembrane chloride flux has emerged as a promising strategy for inducing cancer-cell death through disruption of intracellular pH gradients and subsequent apoptosis. Herein, we report the design and synthesis of novel ortho-phenylenediamine (o-PDA) bisurea derivatives bearing carboxyl (5a–f) and…
Authors not listed
The design of Cu(II) metallodrugs has traditionally emphasized strong DNA binding as a proxy for anticancer efficacy, but this paradigm has rarely been questioned. Herein, we report two new Cu(II) aroyl-hydrazone Schiff base complexes containing either a pyrrole (Complex 1) or a furan (Complex 2) moiety, which exhibit…
Zachary Schwehr
—Cancer is the second leading cause of death, with chemotherapy as one of the primary forms of treatment. As a result, researchers are turning to drug combination therapy to decrease drug resistance and increase efficacy. Current methods of drug combination screening, such as in vivo and in vitro, are inefficient due…
HACHEMI KADRI, Mesk Alshatfa, Feras Z Alsalloum, Abdelbary Elhissi + 2 more
Cancer, a global health burden, is characterized by uncontrolled cell growth and metastasis, often resulting in debilitating treatments and mortality. While conventional therapeutic strategies have improved survival rates, they are limited by challenges such as off-target toxicity and drug resistance. With their design…
Saheed Oluwasina Oseni, Genesis Acosta Laguer, Faika Ambrin, Magdalah Philemy + 2 more
There is currently no definitive cure for metastatic castration-resistant prostate cancer (mCRPC), therefore justifying the incessant need for more investigative studies to either repurpose old drugs or identify novel and effective therapeutics. In this study, we investigated the possible anticancer effects of two…
Isabelle Holzer, Oksana Desiatkina, Nicoleta Anghel, Serena K. Johns + 4 more
Eight novel carbohydrate-tethered trithiolato dinuclear ruthenium(II)-arene complexes were synthesized using CuAAC 'click' (Cu(I)-catalyzed azide-alkyne cycloaddition) reactions and, together with the diruthenium intermediates, were assessed for their in vitro activity against transgenic Toxoplasma gondii (T. gondii)…
Ajay Kumar, Swati Swami, Nilesh Kumar Sharma
The tumor microenvironment, including microbiome populations in the local niche of several types of solid tumors like mammary and colorectal cancer are distinct. The occurrence of one type of cancer over another varies from animals to human individuals. Further, clinical data suggest that specific cancer types such as…
Kavita Iyer, Julian Ivanov, Rumiana Tenchov, Krittika Ralhan + 4 more
Rapid and sustained growth in the field of immuno-oncology has resulted in expansion of available scientific literature. Gaining valuable insights and establishing deep and often hidden meaningful connections in such a large body of work is the need of the hour. In this report we summarize our findings from a novel…
Authors not listed
Twelve thiosemicarbazones and twenty-four of their Cu(II) and Pd(II) complexes were synthesized and studied in terms of physicochemical properties and biological activities. Single crystal X-ray diffraction and mass spectrometry confirmed ligand deprotonation and the formation of ML2-type complexes. All compounds were…