20 papers · ranked by Valyu relevance
Agnieszka Gęgotek, Elżbieta Skrzydlewska, Giancarlo Aldini, Alessandra Altomare + 1 more
'Alessandra Altomare' 'Giovanna Baron'] Ascorbic acid, as a one of the basic exogenous vitamins, occurs in the body in the form of ascorbate, known for its strong antioxidant and anti-inflammatory properties. The presented review shows not only the importance of ascorbate as a free radical scavenger but also summarizes…
Xin Yin, Kaiwen Chen, Hao Cheng, Xing Chen + 4 more
The L-enantiomer of ascorbic acid is commonly known as vitamin C. It is an indispensable nutrient and plays a key role in retaining the physiological process of humans and animals. L-gulonolactone oxidase, the key enzyme for the de novo synthesis of ascorbic acid, is lacking in some mammals including humans. The…
Rodrigo Figueroa-Méndez, Selva Rivas-Arancibia
Ever since Linus Pauling published his studies, the effects of vitamin C have been surrounded by contradictory results. This may be because its effects depend on a number of factors such as the redox state of the body, the dose used, and also on the tissue metabolism. This review deals with vitamin C pharmacokinetics…
Alexander Muacevic, John R Adler, Harshit R Bhoot, Udit M Zamwar + 2 more
'Swarupa Chakole' 'Ashish Anjankar'] Ascorbic acid is also popularly known as vitamin C or ascorbate. It is a water-soluble vitamin. Ascorbic acid is necessary for bone formation, wound healing, connective tissue growth, and the maintenance of healthy gum tissue. Antioxidants like ascorbic acid shield the body from…
Andrei Cristian Grădinaru, Setalia Popa, Francois Lefort
Vitamin C is an organic compound biosynthesized in plants and most vertebrates. Since its discovery, the benefits of vitamin C use in the cure and prevention of various pathologies have been frequently reported, including its anti-oxidant, anti-inflammatory, anticoagulant, and immune modulatory properties. Vitamin C…
Hussein A. Algahtani, Abduljaleel P. Abdu, Imad M. Khojah, Ali M. Al-Khathaami
'Ali M. Al-Khathaami'] Scurvy has become rare in modern societies, but should be considered in malnourished persons, alcoholics, and in infants on unsupplemented milk diets who present with musculoskeletal pain or a bleeding tendency. The diagnosis of scurvy can be challenging because of the rare incidence and vague…
Ioan Bâldea
Antioxidants operate in biological environments where solvent effects dramatically alter their redox properties. Using ascorbic acid (vitamin C) as a paradigmatic example, we present a comprehensive quantum-chemical investigation of its global chemical reactivity indices—ionization potential, electron affinity…
Harpreet Kaur, Shubham Tiwari, Aman Kumar, Sandeep Kumar Jha + 2 more
Oxidative stress is a key factor in low fertility outcomes during assisted reproduction technology (ART) and contributes to poor sperm quality. Conventional assessment relies on bright-field microscopy, which lacks the quantitative sensitivity to resolve subcellular structural and biophysical changes without exogenous…
Florence Grenapin, Alessio D’Errico, Ebrahim Karimi
Some anisotropic materials form semicristalline structures, called spherulites, which observed in a polarisation microscope, exhibit a characteristic "maltese-cross"-like pattern. While this observation has been hitherto considered as a tool to characterize these materials, we show that these patterns are associated…
Himanshu Sen, Manpreet Kaur, Saumya Raychaudhuri
Cholera, a deadly diarrheal disease, continues to ravage various parts of the world. It is caused by Vibrio cholerae, an important member of gamma-proteobacteria. Based on certain genetic and phenotypic tests, the organism is classified in two major biotypes namely classical and El Tor. The El Tor and its variants are…
Diogo Oliveira, André M. Machado, Tiago Cardoso, Mónica Lopes-Marques + 2 more
Nucleobase-Ascorbate Transporter (NAT) family includes ascorbic acid, nucleobases and uric acid transporters: with a broad evolutionary distribution. In vertebrates, four members have been previously recognized, the ascorbate transporters Slc23a1 and Slc3a2, the nucleobase transporter Slc23a4 and an orphan transporter…
Bergoi Ibarlucea, Arnau Pérez Roig, D. K. Belyaev, Larysa Baraban + 1 more
'Gianaurelio Cuniberti'] We demonstrate a flexible sensor for ascorbic acid detection in sweat based on singlestep modified gold microelectrodes. The modification consists on the electrodeposition of alginate membrane with trapped CuO nanoparticles on top of the electrodes. The electrodes are fabricated at a thin…
Shun Kishimoto, Daniel R. Crooks, Otowa Yasunori, Yamashita Kota + 5 more
Hypoxic tumor microenvironments pose a significant challenge in cancer treatment. Hypoxia-activated prodrugs like evofosfamide aim to specifically target and eliminate these resistant cells. However, their effectiveness is often limited by reoxygenation after cell death. We hypothesized that ascorbate’s pro-oxidant…
Mahmood Rasheed, Gary Simmons, Bernard Fisher, Kevin Leslie + 5 more
Hematopoietic cell transplantation (HCT) conditioned using myeloablative conditioning (MAC) is complicated by end organ injury due to endothelial dysfunction and graft versus host disease. Mucositis and oxidant injury results in micronutrient deficiency. Ascorbic acid (AA) levels were measured in 15 patients undergoing…
Yoshihiro Yamazaki, Mitsunobu Kikuchi, Akihiko Toda, Jun-ichi Wakita + 1 more
'Mitsugu Matsushita'] There exists the threshold-sensitive dynamical transition between the uniform and the periodic growth modes in the domain growth of ascorbic acid crystals from its aqueous supersaturated solution film. The crystal growth induces the solution flow. Humidity controls the fluidity of the solution.…
Hidam Bishworjit Singh, Mohammad Imtiyaj Khan
Betalamic acid is the chromophore of betalains, which are pigments of chemotaxonomic and physiological importance. This study involves RACE-PCR-based gene cloning, heterologous expression, protein purification, and steady-state kinetics of B. alba L. var. ‘Rubra’ L-DOPA/dopamine-4,5-dioxygenase 1 (BrDOD1). BrDOD1 is a…
Laura L Driscoll, Abbey Jarvis, Rosie Madge, Jamie-Marie Price + 9 more
Large-scale recycling and regeneration of lithium-ion cathode materials is hindered by the complex mixture of chemistries often present in the waste stream. We outline an efficient process for the separation and regeneration of phases within a blended cathode. We demonstrate the efficacy of this approach using cathode…
Marwa Fouad
Thiazoles and pyrazolo[5,1-c][1,2,4]triazoles have attracted particular attention due to their reported biological and therapeutic effects, so the ultimate objective of the current research is to develop some novel heterocyclic ingredients with thiazole and pyrazolo[5,1-c][1,2,4]triazole constituents that have…
Authors not listed
Note on the Historical Context of This Submission This work was originally conducted in 2008 but was not published at the time due to limited recognition of non-biological phosphate turnover mechanisms. In the years since, growing evidence has accumulated for abiotic phosphatase-like activity in minerals, inorganic…
Authors not listed
Endophytic fungus are widely distributed in medicinal plants and the Penicillium species that recovered from plant tissues directly provide an attractive resource of structurally and biologically diverse natural products. For the sake of clarity, in this review only Penicillium strains derived from medicinal plants are…