19 papers · ranked by Valyu relevance
Xin Yin, Kaiwen Chen, Hao Cheng, Xing Chen + 4 more
The L-enantiomer of ascorbic acid is commonly known as vitamin C. It is an indispensable nutrient and plays a key role in retaining the physiological process of humans and animals. L-gulonolactone oxidase, the key enzyme for the de novo synthesis of ascorbic acid, is lacking in some mammals including humans. The…
Agnieszka Gęgotek, Elżbieta Skrzydlewska, Giancarlo Aldini, Alessandra Altomare + 1 more
'Alessandra Altomare' 'Giovanna Baron'] Ascorbic acid, as a one of the basic exogenous vitamins, occurs in the body in the form of ascorbate, known for its strong antioxidant and anti-inflammatory properties. The presented review shows not only the importance of ascorbate as a free radical scavenger but also summarizes…
Jenifer da Silva Mendonça, Rita de Cássia Avellaneda Guimarães, Verônica Assalin Zorgetto-Pinheiro, Carolina Di Pietro Fernandes + 8 more
Antioxidants have drawn the attention of the scientific community due to being related to the prevention of various degenerative diseases. The antioxidant capacity has been extensively studied in vitro, and different methods have been used to assess its activity. However, the main issues related to studying natural…
Alexander Muacevic, John R Adler, Harshit R Bhoot, Udit M Zamwar + 2 more
'Swarupa Chakole' 'Ashish Anjankar'] Ascorbic acid is also popularly known as vitamin C or ascorbate. It is a water-soluble vitamin. Ascorbic acid is necessary for bone formation, wound healing, connective tissue growth, and the maintenance of healthy gum tissue. Antioxidants like ascorbic acid shield the body from…
Florence Grenapin, Alessio D’Errico, Ebrahim Karimi
Some anisotropic materials form semicristalline structures, called spherulites, which observed in a polarisation microscope, exhibit a characteristic "maltese-cross"-like pattern. While this observation has been hitherto considered as a tool to characterize these materials, we show that these patterns are associated…
Andrei Cristian Grădinaru, Setalia Popa, Francois Lefort
Vitamin C is an organic compound biosynthesized in plants and most vertebrates. Since its discovery, the benefits of vitamin C use in the cure and prevention of various pathologies have been frequently reported, including its anti-oxidant, anti-inflammatory, anticoagulant, and immune modulatory properties. Vitamin C…
Ioan Bâldea
Antioxidants operate in biological environments where solvent effects dramatically alter their redox properties. Using ascorbic acid (vitamin C) as a paradigmatic example, we present a comprehensive quantum-chemical investigation of its global chemical reactivity indices—ionization potential, electron affinity…
Harpreet Kaur, Shubham Tiwari, Aman Kumar, Sandeep Kumar Jha + 2 more
Oxidative stress is a key factor in low fertility outcomes during assisted reproduction technology (ART) and contributes to poor sperm quality. Conventional assessment relies on bright-field microscopy, which lacks the quantitative sensitivity to resolve subcellular structural and biophysical changes without exogenous…
Himanshu Sen, Manpreet Kaur, Saumya Raychaudhuri
Cholera, a deadly diarrheal disease, continues to ravage various parts of the world. It is caused by Vibrio cholerae, an important member of gamma-proteobacteria. Based on certain genetic and phenotypic tests, the organism is classified in two major biotypes namely classical and El Tor. The El Tor and its variants are…
Shun Kishimoto, Daniel R. Crooks, Otowa Yasunori, Yamashita Kota + 5 more
Hypoxic tumor microenvironments pose a significant challenge in cancer treatment. Hypoxia-activated prodrugs like evofosfamide aim to specifically target and eliminate these resistant cells. However, their effectiveness is often limited by reoxygenation after cell death. We hypothesized that ascorbate’s pro-oxidant…
Prolay Halder, Himanshu Sen, Sanjib Das, Pritam Nandy + 4 more
In the last three centuries, our world has experienced seven cholera pandemics. Cholera is a deadly diarrheal disease caused by Vibrio cholerae, an important member of the gamma-proteobacteria. Despite conventional treatments like antibiotics, vaccines, and ORS, the 7th cholera pandemic is still a major threat to…
Lea-Sophie Berendes, Petra Schulze Westhoff, Ann-Marie Tobinski, Victoria Wingert + 13 more
Heme oxygenase 1 (HO-1) deficiency is a fatal genetic disorder characterized by impaired heme catabolism, leading to excessive oxidative damage and cell death. Despite evidence from non-human models suggesting mitochondrial dysfunction, the precise pathomechanisms in humans remain unclear, resulting in a lack of…
Zheng Wei
Fluorescence detection is a commonly used analytical method with the advantages of fast response, good selectivity and low destructiveness. However, fluorescence detection, a single-mode detection method, has some limitations, such as background interference that affects the accuracy of the fluorescence signal, lack of…
Hidam Bishworjit Singh, Mohammad Imtiyaj Khan
Betalamic acid is the chromophore of betalains, which are pigments of chemotaxonomic and physiological importance. This study involves RACE-PCR-based gene cloning, heterologous expression, protein purification, and steady-state kinetics of B. alba L. var. ‘Rubra’ L-DOPA/dopamine-4,5-dioxygenase 1 (BrDOD1). BrDOD1 is a…
Xiadi He, Yun Wei, Jiang Wu, Qiwei Wang + 12 more
Vitamin C (vitC) is a vital nutrient for health and also used as a therapeutic agent in diseases such as cancer. However, the mechanisms underlying vitC’s effects remain elusive. Here we report that vitC directly modifies lysine without enzymes to form vitcyl-lysine, termed “vitcylation”, in a dose-, pH-, and…
Laura L Driscoll, Abbey Jarvis, Rosie Madge, Jamie-Marie Price + 9 more
Large-scale recycling and regeneration of lithium-ion cathode materials is hindered by the complex mixture of chemistries often present in the waste stream. We outline an efficient process for the separation and regeneration of phases within a blended cathode. We demonstrate the efficacy of this approach using cathode…
Marwa Fouad
Thiazoles and pyrazolo[5,1-c][1,2,4]triazoles have attracted particular attention due to their reported biological and therapeutic effects, so the ultimate objective of the current research is to develop some novel heterocyclic ingredients with thiazole and pyrazolo[5,1-c][1,2,4]triazole constituents that have…
Authors not listed
Note on the Historical Context of This Submission This work was originally conducted in 2008 but was not published at the time due to limited recognition of non-biological phosphate turnover mechanisms. In the years since, growing evidence has accumulated for abiotic phosphatase-like activity in minerals, inorganic…
Authors not listed
Endophytic fungus are widely distributed in medicinal plants and the Penicillium species that recovered from plant tissues directly provide an attractive resource of structurally and biologically diverse natural products. For the sake of clarity, in this review only Penicillium strains derived from medicinal plants are…