26 papers · ranked by Valyu relevance
Alina Costina Luca, Simona Georgiana David, Alexandru Gabriel David, Viorel Țarcă + 9 more
'Viorel Țarcă' 'Ioana-Alexandra Pădureț' 'Dana Elena Mîndru' 'Solange Tamara Roșu' 'Eduard Vasile Roșu' 'Heidrun Adumitrăchioaiei' 'Jana Bernic' 'Elena Cojocaru' 'Elena Țarcă' 'Damiano D’Ardes'] Cardiovascular disease is the leading cause of mortality and morbidity throughout the world, accounting for 16.7 million…
Pornsak Sriamornsak, Crispin R. Dass, Christian Celia
Chitosan is a natural biopolymer that is present in an abundant supply in sources such as crustacean shells, mushrooms, and insect exoskeletons. It can be used to make a variety of types of drug formulations and is generally safe to use in vivo; plus, it has inherent cholesterol-reducing properties. While an abundance…
Anastasia V. Poznyak, Evgeny E. Bezsonov, Evgeny E. Borisov, Andrey V. Grechko + 3 more
'Andrey V. Grechko' 'Andrey G. Kartuesov' 'Alexander N. Orekhov' 'Monica Currò'] For the past several decades, humanity has been dealing with HIV. This disease is one of the biggest global health problems. Fortunately, modern antiretroviral therapy allows patients to manage the disease, improving their quality of life…
Cristina Madaudo, Giuseppe Coppola, Antonio Luca Maria Parlati, Egle Corrado + 2 more
'Egle Corrado' 'Alessio Ardizzone' 'Emanuela Esposito'] This comprehensive review explores the various scenarios of atherosclerosis, a systemic and chronic arterial disease that underlies most cardiovascular disorders. Starting from an overview of its insidious development, often asymptomatic until it reaches advanced…
Puneetpal Singh, Nitin Kumar, Monica Singh, Manminder Kaur + 10 more
'Gurjinderpal Singh' 'Amit Narang' 'Abhinav Kanwal' 'Kirti Sharma' 'Baani Singh' 'Mario Di Napoli' 'Sarabjit Mastana' 'Vasso Apostolopoulos' 'Jack Feehan' 'Vivek P. Chavda'] Atherosclerosis is the formation of plaque within arteries due to overt assemblage of fats, cholesterol and fibrous material causing a blockage of…
Sonia Benitez, Núria Puig, Pol Camps-Renom, José Luis Sánchez-Quesada
'José Luis Sánchez-Quesada'] The fundamental role of qualitative alterations of lipoproteins in the early development of atherosclerosis has been widely demonstrated. Modified low-density lipoproteins (LDL), such as oxidized LDL (oxLDL), small dense LDL (sdLDL), and electronegative LDL [LDL(-)], are capable of…
Debasmita Mukherjee, Sishu Shankar Muni, Hammed Olawale Fatoyinbo
Atherosclerosis is a chronic inflammatory disease occurs due to plaque accumulation in the inner artery wall. In atherosclerotic plaque formation monocytes and macrophages play a significant role in controlling the disease dynamics. In the present article, the entire biochemical process of atherosclerotic plaque…
Angeliki Chroni, George Leondaritis, Helen Karlsson
Atherosclerosis is a focal disease of the arterial wall that leads to cardiovascular disease (CVD), the biggest cause of morbidity and mortality in Western societies. Atherosclerosis is a complex, chronic, progressive disease that affects large and medium-sized arteries. Atherosclerotic lesions are promoted by…
Mingqiao Li, Patrice Delafontaine, Sergiy Sukhanov
Rapacz pigs with familial hypercholesterolemia (FH pigs) fed with high-fat diet (HFD) develop early atherosclerotic lesions and complex atheromas in coronaries mimicking human coronary atherosclerotic disease (CAD). FH pigs have proven to be an excellent model for basic and pre-clinical atherosclerosis-focused…
Alexander A. Mironov, Galina V. Beznoussenko, Evgeny E. Bezsonov, Igor A. Sobenin + 1 more
'Igor A. Sobenin' 'Alexander N. Orekhov'] Title: Abstract Atherosclerosis is a multicausal disease characterized by the formation of cholesterol-containing plaque in the pronounced intima nearest to the heart’s elastic-type arteries that have high levels of blood circulation. Plaques are formed due to arterial…
Céline Luquain‐Costaz, Isabelle Delton
Atherosclerosis is a major cardiovascular complication of diseases associated with elevated oxidative stress such as type 2 diabetes and metabolic syndrome. In these situations, low density lipoproteins (LDL) undergo oxidation. Oxidized LDL display proatherogenic activities through multiple and complex mechanisms which…
R. L. Ray, Bhaskar Dey
Atherosclerosis, a chronic inflammatory cardiovascular disease, leads to arterial constriction caused by the accumulation of lipids, cholesterol, and various substances within artery walls. Such plaque can rupture, resulting in a blood clot that obstructs major arteries and may initiate myocardial infarction, ischemic…
Andrew Parton, Victoria McGilligan, Maurice O’Kane, Francina R. Baldrick + 1 more
'Francina R. Baldrick' 'Steven Watterson'] Atherosclerosis+is+one+of+the+principle+pathologies+of+cardiovascular+disease+with+blood+cholesterol+a+ significant+ risk+ factor.+ The+ World+ Health+ Organisation estimates+ that+ approximately+ 2.5 million deaths+ occur+ annually due+ to+ the risk+ from+ elevated+…
Zaid Salameh, Edward Jacobs, Rafael Davalos
Atherosclerotic vascular disease remains a leading cause of morbidity and mortality worldwide. Current treatments such as angioplasty, stenting, and atherectomy are invasive and limited by restenosis, thrombosis, and incomplete long-term efficacy. Pulsed field ablation (PFA), a nonthermal electroporation-based…
Kazeem Olanrewaju, Ashlee N. Ford Versypt
The human physiological system consists of several biological units carefully organized to engage in a bio-physicochemical interaction with complex fluids transporting nutritional and life-supporting species (oxygen and carbon dioxide) needed for the proper functioning of the body. The nutritional species are products…
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Atherosclerosis is a disease characterized by the development of atherosclerotic plaques (APs) in arterial endothelium. The APs in part of an arterial wall are inhomogeneous on size and on distribution. In order to understand this in-homogeneity, the pathology of APs is analyzed by Misrepair mechanism, a mechanism…
Vittal S. Rao, M. Naresh Kumar
—Coronary heart disease (CHD) caused by hardening of artery walls due to cholesterol known as atherosclerosis is responsible for large number of deaths world-wide. The disease progression is slow, asymptomatic and may lead to sudden cardiac arrest, stroke or myocardial infraction. Presently, imaging techniques are…
Marco Fernandes, Alisha Patel, Holger Husi
The cardiovascular disease (C/VD) database is an integrated and clustered information resource that covers multi-omic studies (microRNA, genomics, proteomics and metabolomics) of cardiovascular-related traits with special emphasis on coronary artery disease (CAD). This resource was built by mining existing literature…
Abinayaa Rajkumar, Gokulprasanth Panchalingam, Deepthy Jayakumar, Devasimman Perumal + 4 more
A high-cholesterol diet (HCD) is a well-established contributor to oxidative stress, inflammation, and atherogenesis, yet the temporal progression of these pathological changes and the regulatory role of circulating microRNAs (miRNAs) remain incompletely understood. In this study, we investigated the effects of…
Alice Marino, Yi Zhang, Luisa Rubinelli, James E Ip + 1 more
Hypercholesterolemia and hypertension are two major risk factors for coronary artery diseases, which remain the major cause of mortality in the industrialized world. Current animal models of atherosclerosis do not recapitulate coronary plaque disruption, thrombosis and myocardial infarction occurring in human.…
Nihal Ahmed, Ashfaq Ahmed, Sakan Binte Imran
—Atherosclerosis is a state in which plaque (fat, cholesterol, and other substances) builds up inside the arteries that eventually leads to carotid artery stenosis which is a stage of narrowing in the large arteries located on either side of the neck that carry blood to the brain, face, and head. Carotid stenosis is…
Jing Liu, Hisashi Sawada, Deborah A. Howatt, Jessica J. Moorleghen + 3 more
This study determined whether hypercholesterolemia would contribute to both the initiation and progression of angiotensin (Ang)II-induced abdominal aortic aneurysms (AAAs) in mice. To determine whether hypercholesterolemia accelerates the initiation of AAAs, male low-density lipoprotein (LDL) receptor -/- mice were…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Monika Colombo, Yingchao Meng, Marie Poirier-Quinot, Anne-Laure Rollet + 3 more
Iron oxide magnetic nanoparticles have emerged as promising theranostic agents for cardiovascular diseases. Using a multiscale approach, we investigate the interaction of 27 nm diameter multicore magnetite nanoflowers with blood components. Using flow cytometry and dynamic light scattering, we determine safe magnetite…
Authors not listed
Excessive reactive oxygen species (ROS) under pathophysiological conditions primarily initiate oxidative stress, which contributes to the development of atherosclerosis and other cardiovascular diseases. Hydrogen peroxide (H2O2) is a crucial oxidative stress biomarker due to its stability and significant role in…
Noor Abu Jarad, Jeffrey I Weitz, Tohid Didar
Improving the performance of blood-contacting medical implants is a global health necessity aimed at reducing mortality and morbidity in patients with cardiovascular diseases. Surface modification of the biomaterials from which the implants are constructed has been used to reduce the risk of complications such as…