7 papers · ranked by Valyu relevance
Ke Ma, Jingping Ge
Atherosclerosis (AS), a chronic inflammatory disease driven by lipid accumulation and immune dysregulation, predisposes to acute cardiovascular events via plaque rupture and thrombosis. The molecular mechanisms linking immune microenvironment imbalance to plaque instability remain incompletely defined. Utilizing the…
Sepehr Ebrahimi‐Dehkordi, Amir Hossein Barjasteh, Aida Zarei, Sina Bazmi + 8 more
1## Introduction Atherosclerosis (AS) is one of the main causes of death worldwide despite significant therapeutic advances in cardiovascular diseases (CVD) . Since 2019, these entities have been responsible for approximately 18 million deaths annually, accounting for ~ of global mortality . As is determined by…
Alice Bradford, Stefan Bidula, Laszlo Fabian, Derek Warren
Cardiovascular disease involves coordinated remodelling across multiple biological processes. Gene-level signatures vary substantially between studies because different combinations of genes can support similar biological processes. Pathway-level analyses can provide more stable representations of these processes but…
Ke Lv, Huiying Wang, Ying Liu, Xunxiao Zhao + 4 more
Background The relationship between systemic inflammation, plaque vulnerability, and stroke phenotypes in intracranial atherosclerotic stenosis (ICAS) is unclear. This study investigated inflammatory markers’ association with high-risk plaques and their value in differentiating stroke phenotypes and predicting…
Xiaobo Liu, Kailin Shen, Fangtao Zhu, Cunwei Cheng + 1 more
We employed Mendelian randomization (MR) to explore causal relationships between gut microbiota (GM), coronary atherosclerotic heart disease (CAHD), and potential metabolic mediators. We utilized summary statistics from genome-wide association studies (GWAS), encompassing data on 473 GM traits from comprehensive…
Qiang Huang, Qiong Li, Jun-Hong Guo
Ischemic stroke (IS) exhibits notable sex-related differences, indicating a potentially important role for sex hormones such as sex hormone-binding globulin (SHBG), estradiol, and testosterone. This study employed 2-sample Mendelian randomization (MR) to investigate the causal relationships between these sex hormones…
Yanshu Wang, Ningyu Zhu, Amir Rattner, Philip M. Smallwood + 1 more
In CNS endothelial cells (ECs), VEGF signaling promotes vascular permeability, and Wnt/beta-catenin signaling reduces vascular permeability by controlling the gene expression program for the blood-brain barrier. Here we show, using genetic mosaics, that, in mouse brain ECs in vivo, an increase in Wnt/beta-catenin…