25 papers · ranked by Valyu relevance
Stefanie Widder, Javier Macía, Ricard Solé, Mark Isalan
Genetic toggle switches are widespread in gene regulatory networks (GRN). Bistability, namely the ability to choose among two different stable states, is an essential feature of switching and memory devices. Cells have many regulatory circuits able to provide bistability that endow a cell with efficient and reliable…
Jan Rombouts, Lendert Gelens
Bistability is a common mechanism to ensure robust and irreversible cell cycle transitions. Whenever biological parameters or external conditions change such that a threshold is crossed, the system abruptly switches between different cell cycle states. Experimental studies indicate that the shape of the bistable…
Jan Rombouts, Lendert Gelens, Attila Csikász-Nagy
Bistability is a common mechanism to ensure robust and irreversible cell cycle transitions. Whenever biological parameters or external conditions change such that a threshold is crossed, the system abruptly switches between different cell cycle states. Experimental studies have uncovered mechanisms that can make the…
Xavier Richard, Benoît Richard, Christian Mazza, Jan Roelof van der Meer
'Jan Roelof van der Meer'] Prokaryotic gene expression is dynamic and noisy, and can lead to phenotypic variations. Previous work has shown that the selection of such variation can be modeled through basic reaction networks described by O.D.E. displaying a bistable behavior. While previous mathematical studies have…
G. Chorasiya, R. Prakash, S. Sen
Achieving robustness to global perturbations where all parameters can change at the same time is challenging because the controller would also face the same disturbance as the plant. For nonlinear positive feedback, an important mechanism for cell fate determination in biomolecular contexts, quantitative aspects of…
Rodrigo A. Mora-Rodríguez, Jose Guevara-Coto, ManSai Acon, Jorge Torres + 3 more
Macrophages are crucial immune regulators as they can either trigger or resolve inflammation. These properties rely on defined inflammatory states and make macrophages valuable therapeutic targets. Identification of stable steady states and bistability in inflammatory transitions provides deeper insights into immune…
Robert G. Endres
Bistability is considered wide-spread among bacteria and eukaryotic cells, useful e.g. for enzyme induction, bet hedging, and epigenetic switching. However, this phenomenon has mostly been described with deterministic dynamic or well-mixed stochastic models. Here, we map known biological bistable systems onto the…
Naren Ramakrishnan, Upinder S. Bhalla, Herbert M. Sauro
Just as complex electronic circuits are built from simple Boolean gates, diverse biological functions, including signal transduction, differentiation, and stress response, frequently use biochemical switches as a functional module. A relatively small number of such switches have been described in the literature, and…
Andrey Dovzhenok, Alexey Kuznetsov
Many neurons display bistability – coexistence of two firing modes such as bursting and tonic spiking or tonic spiking and silence. Bistability has been proposed to endow neurons with richer forms of information processing in general and to be involved in short-term memory in particular by allowing a brief signal to…
Clarmyra Hayes, Elisenda Feliu, Orkun S Soyer
Here, we focus on a common class of enzymes that have multiple substrate-binding sites (multi-site enzymes), and analyse their capacity to generate bistable dynamics in the reaction systems that they are embedded in. Using mathematical techniques, we show that the inherent binding and catalysis reactions arising from…
Debora Tenenbaum, Juan Ignacio Marrone, Hernán E. Grecco, Alejandra C. Ventura
'Alejandra C. Ventura'] Biological systems are spatially organized. This microscopic heterogeneity has been shown to produce emergent complex behaviors such as bistability. Even though the connection between spatiality and dynamic response is essential to understand biological output, its robustness and extent has not…
Hoon Yeub Jeong, Soo-Chan An, In Cheol Seo, Eunseo Lee + 3 more
'Namhun Kim' 'Young Chul Jun'] Three-dimensional (3D) printing is ideal for the fabrication of various customized 3D components with fine details and material-design complexities. However, most components fabricated so far have been static structures with fixed shapes and functions. Here we introduce bistability to 3D…
Indrani Bose
Systems biology approaches combining theoretical modeling with experiments have been singularly successful in uncovering novel features of cellular phenomena. One such feature is that of binary gene expression in which the expression level is either low or high, i.e., digital in nature. This gives rise to two distinct…
Dan Siegal-Gaskins, Elisa Franco, Tiffany Zhou, Richard M. Murray
Small biomolecular circuits with two distinct and stable steady states have been identified as essential components in a wide range of biological networks, with a variety of mechanisms and topologies giving rise to their important bistable property. Understanding the differences between circuit implementations is an…
Pedro Parra-Rivas, Daniel Ruiz-Reynés, Lendert Gelens
Regular transitions between interphase and mitosis during the cell cycle are driven by changes in the activity of the enzymatic protein complex cyclin B with cyclin-dependent kinase 1 (Cdk1). At the most basic level, this cell cycle oscillator is driven by negative feedback: active cyclin B Cdk1 activates the…
Miriam Leon, Mae L. Woods, Alex J. H. Fedorec, Chris P. Barnes
Background Genetic switches exhibit multistability, form the basis of epigenetic memory, and are found in natural decision making systems, such as cell fate determination in developmental pathways. Synthetic genetic switches can be used for recording the presence of different environmental signals, for changing…
Michael C. Mackey, Marta Tyran‐Kamińska
We consider the dynamics of a population of organisms containing two mutually inhibitory gene regulatory networks, that can result in a bistable switchlike behaviour. We completely characterize their local and global dynamics in the absence of any noise, and then go on to consider the effects of either noise coming…
Konstantin Günther, Niklas Grabicki, Beatrice Battistella, Lutz Grubert + 1 more
Controlling the electronic spin state in single-molecules through an external stimulus is of interest in developing devices for information technology, such as data storage and quantum computing. We report the synthesis and operation mode of two all-organic molecular spin state switches that can be photochemically…
Authors not listed
Molecules exhibiting multifunctional properties, such as magnetic bistability, luminescence, and dielectric properties have excellent potential for application in magnetic optoelectronic devices. Research into luminescent magnets and switching materials is continuously expanding because, in these cases, spin-state…
Authors not listed
In recent world advancement and the quest for smart multi-functional material, stimuli-responsive molecular bistable systems offer unique opportunities to explore their applicability in molecular switches, data storage, and sensing technologies. Multi-stimuli responsive stepwise Spin Crossover (SCO) systems stand tall…
Brandon S. Razooky, Youfang Cao, Alan S. Perelson, Michael L. Simpson + 1 more
Fundamental to biological decision-making is the ability to generate bimodal expression patterns where two alternate expression states simultaneously exist. Here, we use a combination of single-cell analysis and mathematical modeling to examine the sources of bimodality in the transcriptional program controlling HIV’s…
Authors not listed
Phase change materials (PCMs) with distinct optical properties at different phases are promising candidates for programmable photonics, optical communication and photonic computing. In this work, we have studied thermo-optic effect in a PCM-based integrated photonic device comprising a film of bistable [Fe2Co2]…
Aliye Hazal Koyuncu, Jacopo Movilli, Sevil Sahin, Dmitrii V. Kriukov + 2 more
This work describes a competing activation network, which is regulated by chemical feedback at the liquid-surface interface. Feedback loops dynamically tune the concentration of chemical components in living systems, thereby controlling regulatory processes in neural, genetic, and metabolic networks. Advances in…
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Controlling the spin state that influences the magnetic properties of radical species using external stimuli has been a challenge with potential applications in the emerging fields of spintronics, information technology, high-density data storage, and quantum computations. Although spin state flipping is traditionally…
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This paper formally defines an operational isomorphism between spectral damping in molecular vibronic systems and neuromodulatory control in biological sensory systems. Without asserting causal continuity or physical identity across scales, we show that both domains instantiate the same class of output-selective…