24 papers · ranked by Valyu relevance
Ajai R. Singh, Shakuntala A. Singh
Brain, Mind and Consciousness are the research concerns of psychiatrists, psychologists, neurologists, cognitive neuroscientists and philosophers. All of them are working in different and important ways to understand the workings of the brain, the mysteries of the mind and to grasp that elusive concept called…
Alexey Semyanov, Alexei Verkhratsky
“We hold these truths to be self-evident, that all cells in the brain are created equal and work in concert thus producing our emotions, and thoughts, and behaviors.” Paraphrasing Declaration of Independence of the thirteen United States of America, 1776. The human brain (as well as brains of other mammals) is a…
Taylor Bolt, Lucina Q. Uddin
A reader of the peer-reviewed neuroscience literature will often encounter expressions like the following: ‘the brain is a dynamic system’, ‘the brain is a complex network’, or ‘the brain is a highly metabolic organ’. These expressions attempt to define the essential functions and properties of the mammalian or human…
Sunil K. Pandya
Treatment of diseases of the brain by drugs or surgery necessitates an understanding of its structure and functions. The philosophical neurosurgeon soon encounters difficulties when localising the abstract concepts of mind and soul within the tangible 1300-gram organ containing 100 billion neurones. Hippocrates had…
Jiawei Zhang
In this paper, we will provide an introduction to the brain structure and function. Brain is an astonishing living organ inside our heads, weighing about 1.5kg, consisting of billions of tiny cells. The brain enables us to sense the world around us (to touch, to smell, to see and to hear, etc.), to think and to respond…
George Spanoudis, Andreas Demetriou
The relations between the developing mind and developing brain are explored. We outline a theory of intellectual development postulating that the mind comprises four systems of processes (domain-specific, attention and working memory, reasoning, and cognizance) developing in four cycles (episodic, realistic…
Taylor Bolt, Lucina Q. Uddin
A reader of the peer-reviewed neuroscience literature will often encounter expressions like the following: ‘the brain is a dynamic system’, ‘the brain is a complex network’, or ‘the brain is a highly metabolic organ’. These expressions attempt to define the essential functions and properties of the mammalian or human…
Authors not listed
Molecular mechanisms governing initiation steps of the assembly of thousands of endogenous multi-protein complexes (EMCs) remain incompletely understood. Here, multiple lines of observations are reported reflecting the biological functions-aligned initiation sequence of hybrid assembly pathways (HAPs) of EMCs. HAPs…
Nicolas Rouleau, Nicholas Cimino, James Sonne, Xavier Gallart-Palau
Identifying a complete, accurate model of brain function would allow neuroscientists and clinicians to make powerful neuropsychological predictions and diagnoses as well as develop more effective treatments to mitigate or reverse neuropathology. The productive model of brain function, which has been dominant in the…
Włodzisław Duch
Phenomics is concerned with detailed description of all aspects of organisms, from their physical foundations at genetic, molecular and cellular level, to behavioural and psychological traits. Neuropsychiatric phenomics, endorsed by NIMH, provides such broad perspective to understand mental disorders. It is clear that…
Denis Le Bihan
Considering the very large body of knowledge which neuroimaging has put at our fingertips over the last three decades we looked at the brain with a fresh view which could unveil those "old" things in new ways, in a framework which could help us making predictions tailored made for a scrutiny with the outstanding…
Vikram Chandra, Mehrana R. Nejad, Allison P. Kann, Ananya Salem + 3 more
Brains likely evolved from diffuse nerve nets in the Precambrian, but we do not know what the first brains looked like or how they were organized. Acoel worms, the sister lineage to all other animals with brains, offer a window into this transition. We studied the three-banded panther worm Hofstenia miamia, whose brain…
Siddhartha Sen
In this paper a theoretical model for measuring consciousness based on experimental observations is proposed. Consciousness, the awareness of one's self and one's immediate environment, is defined, in this paper, in terms of the information about this awareness that is contained in or being processed by the brain. This…
Lüder Deecke
I have been asked to write a few words on consciousness in this editorial issue. My thoughts on consciousness will focus on the relation between consciousness and will. Consciousness is not an epiphenomenon as some people believe-it is not a psychological construct either. Consciousness is a brain function. With deeper…
Damian G. Kelty‐Stephen, Paul E. Cisek, Benjamin De Bari, James Dixon + 7 more
'James Dixon' 'Luis H. Favela' 'Fred Hasselman' 'Fred Keijzer' 'Vicente Raja' 'Jeffrey B. Wagman' 'Brandon J. Thomas' 'Madhur Mangalam'] The brain-as-computer metaphor has anchored the professed computational nature of mind, wresting it down from the intangible logic of Platonic philosophy to a material basis for…
Aki Nikolaidis, Aron K. Barbey
Scientific discovery and insight into the biological foundations of human intelligence have advanced considerably with progress in neuroimaging. Neuroimaging methods allow for not only an exploration of what biological characteristics underlie intelligence and creativity, but also a detailed assessment of how these…
Kuranosuke Takagi, Osamu Kondo
The uniqueness of human brain growth and development has been considered promising to understand the advanced cognitive ability of humans. Compared with that of chimpanzees, the human endocranium undergoes several characteristic shape changes immediately after birth, which has been termed “endocranial globularization.”…
Vladimir Shalgunov, Sara Irence Lopes van den Broek, Ida Vang Andersen, Rocío García Vázquez + 12 more
Vladimir Shalgunov 1 , Sara Lopes van den Broek 1 , Ida Vang Andersen 1 , Rocío García Vázquez 1 , Nakul Raval 1 , Mikael Palner 1 , Yuki Mori 1 , Gabriela Schäfer 2 , Hannes Mikula 3 , Natalie Beschorner 1 , Maiken Nedergaard 1 , Stina Syvänen 4 , Matthias Barz 2 , Gitte Moos Knudsen 1 , Umberto Maria Battisti 1 …
Miriam Bassler, Jonas Hiller, Frank Wackenhut, Sven zur Oven-Krockhaus + 9 more
Malignant primary brain tumors are a group of highly aggressive and often infiltrating tumors that lack adequate therapeutic treatments to achieve long time survival. Complete tumor removal is one precondition to reach this goal. A promising approach to optimize resection margins and eliminate remaining infiltrative…
Isabella Schapira, Lillian Russo-Savage, Terdha Narla, Maggie O'Neill + 3 more
Despite the fact that tryptophan is an essential amino acid that humans typically obtain through diet, there are several interesting tryptophan dynamics at play in the body. Quantifying and understanding these dynamics are crucial in studies of depression, autism spectrum disorder, and other disorders that involve…
Jiwon Lee
Dopamine is a hormone that is released by the adrenal gland and influences motor control and motivation. Dopamine is known to have 5 receptors which are D1, D2, D3, D4 and D5, which are further categorized into 2 families: D1 family and D2 family. The D1 family is known to play a role in motivation and motor control…
Melody M.Y. Chan, Matthew A. Lambon Ralph, Gail A. Robinson
Humans can create impressive art, make major scientific breakthroughs, and generate creative solutions that solve everyday life problems. But how are these creative activities supported by the brain? This question is of great scientific interest but remains unanswered. New hypotheses, grounded in converging evidence…
wenzhong liu, hualan li
Infection with the Zika virus results in severe neurological disease in adults or congenital Zika syndrome in newborns. We employed the domain search strategy to study the Zika virus glycoprotein E in this work. The results revealed that immature E contains a NGF domain…
Wojciech Michno, Patrick Wehrli, Srinivas Koutarapu, Christian Marsching + 9 more
Understanding of Alzheimer’s disease (AD) pathophysiology, requires molecular assessment of how key pathological factors, specifically amyloid β (Aβ) plaques, influence the surrounding microenvironment. Here, neuronal lipids are particularly of interest as these are implicated in pathological- and neurodegenerative…