27 papers · ranked by Valyu relevance
Alexey Semyanov, Alexei Verkhratsky
“We hold these truths to be self-evident, that all cells in the brain are created equal and work in concert thus producing our emotions, and thoughts, and behaviors.” Paraphrasing Declaration of Independence of the thirteen United States of America, 1776. The human brain (as well as brains of other mammals) is a…
Katrin Amunts, Javier DeFelipe, Cyriel Pennartz, Alain Destexhe + 11 more
'Michele Migliore' 'Philippe Ryvlin' 'Steve Furber' 'Alois Knoll' 'Lise Bitsch' 'Jan G. Bjaalie' 'Yannis Ioannidis' 'Thomas Lippert' 'Maria V. Sanchez-Vives' 'Rainer Goebel' 'Viktor Jirsa'] Title: Visual Abstract
Taylor Bolt, Lucina Q. Uddin
A reader of the peer-reviewed neuroscience literature will often encounter expressions like the following: ‘the brain is a dynamic system’, ‘the brain is a complex network’, or ‘the brain is a highly metabolic organ’. These expressions attempt to define the essential functions and properties of the mammalian or human…
Jiawen Yang, Sen-Fang Sui, Zheng Liu
The brain is one of the most complex organs in nature. In this organ, multiple neurons, neuron clusters, or multiple brain regions are interconnected to form a complex structural network where various brain functions are completed through interaction. In recent years, multiple tools and techniques have been developed…
Taylor Bolt, Lucina Q. Uddin
A reader of the peer-reviewed neuroscience literature will often encounter expressions like the following: ‘the brain is a dynamic system’, ‘the brain is a complex network’, or ‘the brain is a highly metabolic organ’. These expressions attempt to define the essential functions and properties of the mammalian or human…
Authors not listed
Molecular mechanisms governing initiation steps of the assembly of thousands of endogenous multi-protein complexes (EMCs) remain incompletely understood. Here, multiple lines of observations are reported reflecting the biological functions-aligned initiation sequence of hybrid assembly pathways (HAPs) of EMCs. HAPs…
Nicolas Rouleau, Nicholas Cimino, James Sonne, Xavier Gallart-Palau
Identifying a complete, accurate model of brain function would allow neuroscientists and clinicians to make powerful neuropsychological predictions and diagnoses as well as develop more effective treatments to mitigate or reverse neuropathology. The productive model of brain function, which has been dominant in the…
Vikram Chandra, Mehrana R. Nejad, Allison P. Kann, Ananya Salem + 5 more
The origin of brains in the Precambrian was a landmark in animal evolution, enabling new behavior and life histories. Brains likely evolved from diffuse nerve nets, but we do not know what the first brains looked like or how they were organized. Acoel worms, the likely sister lineage to all other animals with brains…
Nitish Singh Jangwan, Ghulam Md Ashraf, Veerma Ram, Vinod Singh + 3 more
'Badrah S. Alghamdi' 'Adel Mohammad Abuzenadah' 'Mamta F. Singh'] Ever since the dawn of antiquity, people have strived to improve their cognitive abilities. From the advent of the wheel to the development of artificial intelligence, technology has had a profound leverage on civilization. Cognitive enhancement or…
Evgenii Gusev, Alexey Sarapultsev, Maria Komelkova, Moses O. Sokunbi
Consciousness remains one of the most critical yet least understood functions of the brain, not only in humans but also in certain highly organized animal species. In this review, we propose treating consciousness as an emergent, goal-directed informational system organized by the subjective “self” as an active…
Damian G. Kelty‐Stephen, Paul E. Cisek, Benjamin De Bari, James Dixon + 7 more
'James Dixon' 'Luis H. Favela' 'Fred Hasselman' 'Fred Keijzer' 'Vicente Raja' 'Jeffrey B. Wagman' 'Brandon J. Thomas' 'Madhur Mangalam'] The brain-as-computer metaphor has anchored the professed computational nature of mind, wresting it down from the intangible logic of Platonic philosophy to a material basis for…
Charles Johnstone, Prashant S. Alegaonkar
The way we view the reality of nature, including ourselves, depend on consciousness.It also defines the identity of the person, since we know people in terms of their experiences. In general, consciousness defines human existence in this universe. Furthermore, consciousness is associated with the most debated problems…
Vikram Chandra, Mehrana R. Nejad, Allison P. Kann, Ananya Salem + 3 more
Brains likely evolved from diffuse nerve nets in the Precambrian, but we do not know what the first brains looked like or how they were organized. Acoel worms, the sister lineage to all other animals with brains, offer a window into this transition. We studied the three-banded panther worm Hofstenia miamia, whose brain…
Birgitta Dresp
In the field theories in physics, any particular region of the presumed space-time continuum and all interactions between elementary objects therein can be objectively measured and/or accounted for mathematically. Since this does not apply to any of the field theories, or any other neural theory, of consciousness…
Seyed Samie Alizadeh Darbandi, Alex Fornito, Abdorasoul Ghasemi
Network control theory can be used to model how one should steer the brain between different states by driving a specific region with an input. The needed energy to control a network is often used to quantify its controllability, and controlling brain networks requires diverse energy depending on the selected input…
Zamzuri Idris, Jafri Malin Abdullah, Abdul Rahman Izaini Ghani, Zaitun Zakaria + 4 more
The cranium houses the brain, and layers formed by the scalp, cranial bones, and meninges protect it from external energy, including light. Therefore, the brain can be viewed as a black body in a black box. The layers also protect the brain from external atmospheric or gravity force, and together with cerebrospinal…
Peter Coppola
How subjective experience (i.e., consciousness) arises out of objective material processes has been called the hard problem. The neuroscience of consciousness has set out to find the sufficient conditions for consciousness and theoretical and empirical endeavours have placed a particular focus on the cortex and…
Kuranosuke Takagi, Osamu Kondo
The uniqueness of human brain growth and development has been considered promising to understand the advanced cognitive ability of humans. Compared with that of chimpanzees, the human endocranium undergoes several characteristic shape changes immediately after birth, which has been termed “endocranial globularization.”…
Santosh A. Helekar
Existing noninvasive neurophysiological recording methods can acquire neuronal correlates of consciousness, but they do not differentiate between conscious and unconscious states mechanistically. Here we describe a method that detects a new physical effect of apparent neural origin in the peri-somatic space that might…
Vladimir Shalgunov, Sara Irence Lopes van den Broek, Ida Vang Andersen, Rocío García Vázquez + 12 more
Vladimir Shalgunov 1 , Sara Lopes van den Broek 1 , Ida Vang Andersen 1 , Rocío García Vázquez 1 , Nakul Raval 1 , Mikael Palner 1 , Yuki Mori 1 , Gabriela Schäfer 2 , Hannes Mikula 3 , Natalie Beschorner 1 , Maiken Nedergaard 1 , Stina Syvänen 4 , Matthias Barz 2 , Gitte Moos Knudsen 1 , Umberto Maria Battisti 1 …
wenzhong liu, hualan li
Infection with the Zika virus results in severe neurological disease in adults or congenital Zika syndrome in newborns. We employed the domain search strategy to study the Zika virus glycoprotein E in this work. The results revealed that immature E contains a NGF domain…
Robert Worden
Neural theories of consciousness face three difficulties: (1) The selection problem: how are those neurons which create consciousness selected, from all the other neurons which do not? (2) the precision problem: how do neurons hold a detailed internal model of 3D space, as the origin of our spatial conscious…
Miriam Bassler, Jonas Hiller, Frank Wackenhut, Sven zur Oven-Krockhaus + 9 more
Malignant primary brain tumors are a group of highly aggressive and often infiltrating tumors that lack adequate therapeutic treatments to achieve long time survival. Complete tumor removal is one precondition to reach this goal. A promising approach to optimize resection margins and eliminate remaining infiltrative…
Isabella Schapira, Lillian Russo-Savage, Terdha Narla, Maggie O'Neill + 3 more
Despite the fact that tryptophan is an essential amino acid that humans typically obtain through diet, there are several interesting tryptophan dynamics at play in the body. Quantifying and understanding these dynamics are crucial in studies of depression, autism spectrum disorder, and other disorders that involve…
Jiwon Lee
Dopamine is a hormone that is released by the adrenal gland and influences motor control and motivation. Dopamine is known to have 5 receptors which are D1, D2, D3, D4 and D5, which are further categorized into 2 families: D1 family and D2 family. The D1 family is known to play a role in motivation and motor control…
Melody M.Y. Chan, Matthew A. Lambon Ralph, Gail A. Robinson
Humans can create impressive art, make major scientific breakthroughs, and generate creative solutions that solve everyday life problems. But how are these creative activities supported by the brain? This question is of great scientific interest but remains unanswered. New hypotheses, grounded in converging evidence…
Wojciech Michno, Patrick Wehrli, Srinivas Koutarapu, Christian Marsching + 9 more
Understanding of Alzheimer’s disease (AD) pathophysiology, requires molecular assessment of how key pathological factors, specifically amyloid β (Aβ) plaques, influence the surrounding microenvironment. Here, neuronal lipids are particularly of interest as these are implicated in pathological- and neurodegenerative…