27 papers · ranked by Valyu relevance
Rahel Paloots, Ziying Yang, Michael Baudis
Cancer cell lines are frequently used in biological and translational research to study cellular mechanisms and explore treatment options. However, cancer cell lines may display mutational profiles divergent from native cancers or may be misidentified or contaminated. We explored how similar cancer cell lines are to…
Rahel Paloots, Michael Baudis
Cancer cell lines are an important component in biological and medical research, enabling studies of cellular mechanisms as well as the development and testing of pharmaceuticals. Genomic alterations in cancer cell lines are widely studied as models for oncogenetic events and are represented in a wide range of primary…
Marina Salvadores, Francisco Fuster-Tormo, Fran Supek
Cell lines are commonly used as cancer models. Because the tissue and/or cell type of origin provide important context for understanding mechanisms of cancer, we systematically examined whether cell lines exhibit features matching the cancer type that supposedly originated them. To this end, we aligned the mRNA…
Florian T. Unger, Irene Witte, Kerstin A. David
Since the introduction of chemotherapy for cancer treatment in the early 20th century considerable efforts have been made to maximize drug efficiency and at the same time minimize side effects. As there is a great interpatient variability in response to chemotherapy, the development of predictive biomarkers is an…
Jones, Catarina Franco, Dias, Diogo + 14 more
Breast cancer cell lines are indispensable tools for unraveling disease mechanisms, enabling drug discovery, and developing personalized treatments, yet their heterogeneity and inconsistent classification pose significant challenges in model selection and data reproducibility. This review aims at providing a…
Rileen Sinha, Nikolaus Schultz, Chris Sander
Cancer cell lines are often used in laboratory experiments as models of tumors, although they can have substantially different genetic and epigenetic profiles compared to tumors. We have developed a general computational method – TumorComparer - to systematically quantify similarities and differences between tumor…
James L. Mulshine, Peter Ujhazy, Melissa Antman, Christine M. Burgess + 9 more
'Christine M. Burgess' 'Igor Kuzmin' 'Paul A. Bunn Jr' 'Bruce E. Johnson' 'Jack A. Roth' 'Harvey I. Pass' 'Sheila M. Ross' 'Carolyn R. Aldige' 'Ignacio I. Wistuba' 'John D Minna'] Title: Abstract The intramural the National Cancer Institute (NCI) and more recently the University of Texas Southwestern Medical Center…
Ying Li
I would like to take this opportunity to express my sincere gratitude to my supervisor. I can honestly say that without you, this thesis would not exist. Thank you for being a role model and inspiring me into pursuing an education in the field of Occupational Health. Dr. Héroux runs the lab with his own money, and…
Lauren M. Granat, Ooha Kambhampati, Stephanie Klosek, Brian Niedzwecki + 2 more
'Brian Niedzwecki' 'Kian Parsa' 'Dong Zhang'] Title: Abstract In the era of precision medicine, cancer researchers and oncologists are eagerly searching for more realistic, cost effective, and timely tumor models to aid drug development and precision oncology. Tumor models that can faithfully recapitulate the…
Michael B. Black, Alina Y. Efremenko, Patrick D. McMullen, A. Rasim Barutcu + 1 more
In vitro toxicology has used immortalized cancer cell lines as model human systems for decades. However, these cell lines pose problems in designing toxicity testing programs as they inherently do not represent normal human biology. There is also a huge number of such cell lines to choose from, derived from human…
Cristina Martínez-Hernández, Mariana del Carmen Aguilera-Puga, Fabien Plisson
Current cancer treatments damage healthy cells and tissues, causing short-term and long-term side effects. New treatments are desired that show greater selectivity toward cancer cells and evade the common mechanisms of multidrug resistance. Membranolytic anticancer peptides (mACPs) hold promise against cancer and…
L. Usha, O. Klapko, S. Edassery
Cell-based therapies cure some hematologic malignancies, although little information exists on solid cancer cell responses. The study objective was to test the hypothesis that xenogeneic fibroblasts can inhibit the growth of human cancer cell lines in vitro. Seven human cell lines (pancreatic cancer HPAF II; brain…
SEUNG WOOK KIM, SUN-JIN KIM, ROBERT R. LANGLEY, ISAIAH J. FIDLER
We investigated how varying the composition of cell culture formulations and growing cancer cells at different densities might affect tumor cell genotype. Specifically, we compared gene expression profiles generated by human MDA-MB-231 breast cancer cells cultured in different media [minimum essential medium (MEM)…
Jenna L. Gordon, Mark A. Brown, Melissa M. Reynolds
Determination of therapeutic efficacy is a major challenge in developing treatment options for cancer. Prior to in vivo studies, candidate therapeutics are evaluated using cell-based in vitro methods to assess their anti-cancer potential. This review describes the utility and limitations of evaluating therapeutic…
Yongqi Wu, Kyoung-Joo Jenny Park, Clayton Deighan, Peter Amaya + 5 more
'Brandon Miller' 'Quintin Pan' 'Maciej Zborowski' 'Maryam Lustberg' 'Jeffery Chalmers'] Circulating tumor cells (CTCs) are routinely identified as cytokeratin (CK)-positive, epithelial cell adhesion molecule (EpCAM)-positive, and CD45-negative and are enriched based on EpCAM. However, there are a number of…
Dayun Yan, Jonathan H. Sherman, Jerome Canady, Barry Trink + 1 more
'Michael Keidar'] 1Department of Mechanical and Aerospace Engineering, The George Washington University, Science & Engineering Hall, 800 22nd Street, NW, Washington, DC 20052, USA 2Neurological Surgery, The George Washington University, Foggy Bottom South Pavilion, 22nd Street, NW, 7th Floor, Washington, DC 20037, USA…
Clémence Dubois, Robin Dufour, Pierre Daumar, Corinne Aubel + 5 more
'Claire Szczepaniak' 'Christelle Blavignac' 'Emmanuelle Mounetou' 'Frédérique Penault‐Llorca' 'Mahchid Bamdad'] Triple-Negative Basal-Like tumors, representing 15 to 20% of breast cancers, are very aggressive and with poor prognosis. Targeted therapies have been developed extensively in preclinical and clinical studies…
Authors not listed
While metallodrugs have been known for decades, developing new effective formulations still remains a challenge, underscoring the need for new tools to assist identification of potent metal-containing anticancer agents. In this work, we developed a straightforward data-driven approach to predict cytotoxicity of metal…
Tesfay Tesfatsion, Arianna Collins, Giovanni Ramirez, Yousef Mzannar + 6 more
Cannabinoid receptors CB1 and CB2 are the primary endogenous receptors with which cannabinoids interact, inducing physiological and psychological effects. Although interactions with other receptors including TRPV1 and GPCR55, have been recognized in earlier studies, these interactions may play a significant role in…
Davide Cardella, Louis Yu Pan Luk, Yu-Hsuan Tsai
Despite continuous advances, anticancer therapy still faces several technical hurdles such as selectivity on cellular and subcellular targets of therapeutics. Toward addressing these limitations, we have combined the use of proapoptotic peptides, cyanine dyes and folate to target the mitochondria of tumor cells. Hence…
Ami Shah, Katarzyna A. Rejniak, Jana L. Gevertz
While chemoresistance in primary tumors is well-studied, much less is known about the influence of systemic chemotherapy on the development of drug resistance at metastatic sites. In this work, we use a hybrid spatial model of tumor response to a DNA damaging drug to study how the development of chemoresistance in…
Hanieh Karimi, Paweł Moskal, Ewa Ł. Stępień
It was recently demonstrated that newly invented positronium imaging may be used for improving cancer diagnostics by providing additional information about tissue pathology with respect to the standardized uptake value currently available in positron emission tomography (PET). Positronium imaging utilizes properties of…
Shadeeb Hossain
Bioelectrical properties of cells such as relative permittivity, conductivity, and characteristic time constants vary significantly between healthy and malignant cells across different frequencies. These distinctions provide a promising foundation for diagnostic and classification applications. This study…
Authors not listed
A quantitative high throughput screen (qHTS) of 7,988 compounds with annotated libraries using biliary tract cancer cell lines with or without isocitrate dehydrogenase I (IDH1) mutations had identified YC-1 as being selectively cytotoxic against the IDH1 mutant cell lines. We present the structure-activity relationship…
Authors not listed
The WRN helicase has recently emerged as a promising therapeutic target for microsatellite instability (MSI)-high cancers. Here, we report LXW-P1, a potent WRN degrader derived from marine bromotyrosine alkaloids. Its molecular target was identified using an AI-guided, pathway-informed perturbation transcriptomics…
Ana Vila, Miguel Abal, Laura Muinelo-Romay, Carlos Rodriguez-Abreu + 4 more
'José Rivas' 'Rafael López-López' 'Clotilde Costa' 'Jung Weon Lee'] Circulating tumour cells (CTCs) play a key role in the metastasis process, as they are responsible for micrometastasis and are a valuable tool for monitoring patients in real-time. Moreover, efforts to develop new strategies for CTCs isolation and…
Authors not listed
This paper addresses the challenges in cell line development (CLD), the lengthy and ambiguous clone screening in upstream biopharmaceutical production. Typically, only a small subset of the later stages of CLD data is used for manually selecting lead clones. Addressing this issue, we introduce a multivariate data…