25 papers · ranked by Valyu relevance
Weida Wu, Sarah H. Ishamuddin, Thomas W. Quinn, Smitha Yerrum + 10 more
Cell density, the ratio of cell mass to volume, is an indicator of molecular crowding and therefore a fundamental determinant of cell state and function. However, existing density measurements lack the precision or throughput to quantify subtle differences in cell states, particularly in primary samples. Here we…
An Gong, Mingwei Min
The size and growth of a cell can be described by three related physical parameters: volume, density and mass. All the three are coupled to numerous biochemical reactions and biophysical properties of a cell. It is therefore not surprising that cell size and growth pattern are tightly regulated across all kingdoms of…
Benjamin Figueroa, Fiona Xi Xu, Ruoqian Hu, Shuaiqian Men + 1 more
Cell size and density impact a wide range of physiological functions, including tissue homeostasis, growth regulation, and osmoregulation. Both are tightly regulated in mammalian cells. In comparison, density variation of a given cell type is much smaller than cell size, indicating that maintenance of cell…
Pascal D Odermatt, Teemu P Miettinen, Joël Lemière, Joon Ho Kang + 6 more
'Emrah Bostan' 'Scott R Manalis' 'Kerwyn Casey Huang' 'Fred Chang' 'Mohan K Balasubramanian' 'Naama Barkai'] Intracellular density impacts the physical nature of the cytoplasm and can globally affect cellular processes, yet density regulation remains poorly understood. Here, using a new quantitative phase imaging…
Abin Biswas, Omar Muñoz, Kyoohyun Kim, Carsten Hoege + 5 more
The packing and confinement of macromolecules in the cytoplasm and nucleoplasm has profound implications for cellular biochemistry. How intracellular density distributions vary and affect cellular physiology remains largely unknown. Here, we show that the nucleus is less dense than the cytoplasm and that living systems…
Pascal D. Odermatt, Teemu P. Miettinen, Joon Ho Kang, Emrah Bostan + 3 more
Intracellular density impacts the physical nature of the cytoplasm and can globally affect cellular processes, yet density regulation remains poorly understood. Here, using a new quantitative phase imaging method, we determined that dry-mass density varies during the cell cycle in fission yeast. Density decreased…
Avik Mukherjee, Yanqing Huang, Jens Elgeti, Seungeun Oh + 12 more
Mechanical forces have been shown to influence cellular decisions to grow, die, or differentiate, through largely mysterious mechanisms. Separately, changes in resting membrane potential have been observed in development, differentiation, regeneration, and cancer. We now demonstrate that membrane potential is the…
Aashrith Saraswathibhatla, Jacob Notbohm
Key to collective cell migration is the ability of cells to rearrange their position with respect to their neighbors. Recent theory and experiments demonstrated that cellular rearrangements are facilitated by cell shape, with cells having more elongated shapes and greater perimeters more easily sliding past their…
David Martinez-Martin
Cellular processes, in particular homeostasis and growth, require an intricate and complex exchange of matter between a cell and its surroundings. Yet experimental difficulties have prevented a detailed description of the dynamics of a cell’s mass and volume along different cellular processes, limiting our…
Francisco Feijó Delgado, Nathan Cermak, Vivian C. Hecht, Sungmin Son + 8 more
'Yingzhong Li' 'Scott M. Knudsen' 'Selim Olcum' 'John M. Higgins' 'Jianzhu Chen' 'William H. Grover' 'Scott R. Manalis' 'Michael Polymenis'] We present a method for direct non-optical quantification of dry mass, dry density and water mass of single living cells in suspension. Dry mass and dry density are obtained…
Sang-Woo Lee, Yoshihiro Morishita, Philip K. Maini
Recent technological advances in high-resolution imaging and artificial modulation of genetic functions at different times and regions have enabled direct observations of the formation and elimination of abnormal cell populations. A recent trend in cell competition research is the incorporation of cell mechanics. In…
Steven J. Chisolm, Emily Guo, Vignesh Subramaniam, Kyle D. Schulze + 1 more
in non-Jammed MDCK Monolayers Authors: ['Steven J. Chisolm' 'Emily Guo' 'Vignesh Subramaniam' 'Kyle D. Schulze' 'Thomas E. Angelini'] Transitions between solid-like and fluid-like states in living tissues have been found in steps of embryonic development and in stages of disease progression. Our current understanding…
Teemu P Miettinen, Kevin S Ly, Alice Lam, Scott R Manalis + 2 more
'Jon Pines' 'Jonathan A Cooper'] Cell mass and composition change with cell cycle progression. Our previous work characterized buoyant mass dynamics in mitosis (Miettinen et al., 2019), but how dry mass and cell composition change in mitosis has remained unclear. To better understand mitotic cell growth and…
Steven J. Chisolm, Emily Guo, Vignesh Subramaniam, Kyle D. Schulze + 1 more
Monolayers Authors: ['Steven J. Chisolm' 'Emily Guo' 'Vignesh Subramaniam' 'Kyle D. Schulze' 'Thomas E. Angelini'] The elastic moduli of tissues are connected to their states of health and function. The epithelial monolayer is a simple, minimal, tissue model that is often used to gain understanding of mechanical…
Silja Borring Låstad, Nigar Abbasova, Thomas Combriat, Dag Kristian Dysthe
Collective migration and pulsatile flows in epithelial monolayers are commonly quantified using projected area, implicitly assuming constant cell volume and prism-shaped cells. These 2.5D assumptions ignore the height, volume, and mass dynamics that, in confluent space-filling tissues, must accompany every density…
Helena Bestová, Jules Segrestin, Klaus von Schwartzenberg, Pavel Škaloud + 2 more
'Pavel Škaloud' 'Thomas Lenormand' 'Cyrille Violle'] The Metabolic Scaling Theory (MST), hypothesizes limitations of resource-transport networks in organisms and predicts their optimization into fractal-like structures. As a result, the relationship between population growth rate and body size should follow a…
Steffen Lange, Jannik Schmied, Paul Willam, Anja Voß-Böhme
epithelial colony growth Authors: ['Steffen Lange' 'Jannik Schmied' 'Paul Willam' 'Anja Voß-Böhme'] Regulation of cell proliferation is a crucial aspect of tissue development and homeostasis and plays a major role in morphogenesis, wound healing, and tumor invasion. A phenomenon of such regulation is contact…
Authors not listed
Perovskite solar cells (PSCs) have emerged as a promising technology due to their remarkable efficiency and stability improvements over the years. However, commercialization is hindered by challenges such as material toxicity, high costs, and limited stability. To address these issues, this study investigates vanadium…
Pablo Ángel Prieto-Díaz, Ange A. Maurice, Marcos Vera
The variation of the physical properties of vanadium electrolytes during vanadium redox flow batteries (VRFB) operation is known to have a significant impact on the flow of the electrolytes both in the cells and in the tanks. This study presents extensive accurate measurements of the density and viscosity of vanadium…
Jonathan E. Dawson, Abdul N. Malmi-Kakkada
A variety of living and non-living systems exhibit collective motion. From swarm robotics to bacterial swarms, and tissue wound healing to human crowds, examples of collective motion are highly diverse but all of them share the common necessary ingredient of moving and interacting agents. While collective motion has…
Authors not listed
The ability to track therapeutic cells is critical for advancing adoptive cell therapy (ACT). Positron emission tomography (PET) offers sensitive and quantitative imaging, yet improved cell radiolabeling strategies are sorely needed. We report a metabolic glycoengineering (MGE) approach that installs azide moieties on…
Elizabeth Lawson-Keister, M. Lisa Manning
Collective cell motility is crucial to many biological processes including morphogenesis, wound healing, and cancer invasion. Recently, the biology and biophysics communities have begun to use the term "cell jamming" to describe the collective arrest of cell motion in tissues. Although this term is widely used, the…
Michael F. Staddon, Natalie A. Dye, Marko Popović, Frank Jülicher
Michael F. Staddon,1, 2, 3, 4 Natalie A. Dye,4, 5, 6 Marko Popović,1, 2, 4, 7, ∗ and Frank Jülicher1, 2, 4, † Max Planck Institute for Physics of Complex Systems, Dresden, Germany Center for Systems Biology, Dresden, Germany Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany Cluster of…
Authors not listed
In this study, an all-perovskite solar cell is proposed consists of MASnI3, CsSnI3 and MAGeI3 proposed to replace conventional expensive HTM, ETM. Several physical parameters of each layer (HTM, ETM and Absorber) of the proposed cell including thickness, doping density, defect density, electron affinity, temperature…
Authors not listed
Vertex models have been established as powerful tools for the cell-based simulation of epithelial tissues as they allow a detailed description of their mechanical development with respect to the properties of individual cells. Thus, they suit the challenges of simulating intestinal organoids which arise from the…