25 papers · ranked by Valyu relevance
Jimeng Su, Ying Song, Zhipeng Zhu, Xinyue Huang + 3 more
'Jie Qiao' 'Fengbiao Mao'] Multicellular organisms are composed of diverse cell types that must coordinate their behaviors through communication. Cell-cell communication (CCC) is essential for growth, development, differentiation, tissue and organ formation, maintenance, and physiological regulation. Cells communicate…
Xinyi Wang, Axel A. Almet, Qing Nie
Cell-cell interactions instruct cell fate and function. These interactions are hijacked to promote cancer development. Single-cell transcriptomics and spatial transcriptomics have become powerful new tools for researchers to profile the transcriptional landscape of cancer at unparalleled genetic depth. In this review…
Nayang Shan, Yao Lu, Hao Guo, Dongyu Li + 7 more
Cells are basic units of multicellular organisms, which cooperate with each other to carry out complex physiological functions. Some cells interact directly with others, mainly mediated by gap junctions, cell adhesions and ligand-receptor interactions of membrane proteins (; ; ). Others form indirect cell-cell…
Jakob Löber, Falko Ziebert, Igor S. Aranson
Collective migration of eukaryotic cells plays a fundamental role in tissue growth, wound healing and immune response. The motion, arising spontaneously or in response to chemical and mechanical stimuli, is also important for understanding life-threatening pathologies, such as cancer and metastasis formation. We…
Rebecca M. Crossley, Simon F. Martina-Perez
Electrotaxis, the process by which eukaryotic cells establish a polarity and move directionally along an electric field, is a well-studied mechanism to steer the migration of cells in vitro and in vivo. While the influence of an electric field on single cells in culture is well-documented, the influence of the electric…
James Boyle, Helen M Byrne, Ruth E Baker
Interactions between nearby cells are a key driver of cell movement in many biological systems, including collective cell migration and the immune response to cancer. However, inferring the interaction rules in a given system in a manner that is both accurate and biologically interpretable remains a challenge. A…
Yu Tang, Yanguang Cao
Despite the promising results of therapeutic antibodies in engaging the immune system to eliminate malignant cells, many aspects of the complex interplay between immune cells and cancer cells during antibody therapy remain incompletely understood. This study aimed to develop a biosensor system that can evaluate direct…
David B. Brückner, Nicolas Arlt, Alexandra Fink, Pierre Ronceray + 2 more
'Joachim O. Rädler' 'Chase P. Broedersz'] The migratory dynamics of cells in physiological processes, ranging from wound healing to cancer metastasis, rely on contact-mediated cell-cell interactions. These interactions play a key role in shaping the stochastic trajectories of migrating cells. While data-driven physical…
Ushasi Roy, Tyler Collins, Mohit Kumar Jolly, Parag Katira
| 1 | | Introduction - Collective Cell Migration | 2 | | --- | --- | --- | --- | | 2 | | Factors influencing Collective Cell Migration | 3 | | | 2.1 | Direct Cell-Cell Mechanical Interactions | 3 | | | 2.2 | Direct Cell-Cell Biochemical Interactions | 4 | | | 2.3 | Indirect Cell-Cell Interactions via the Environment |…
Tianjiao Zhang, Zhenao Wu, Liangyu Li, Jixiang Ren + 6 more
'Jingyu Zhang' 'Guohua Wang' 'Clement Agoni' 'Indrani Bera' 'Benoit Coulombe'] The growth, development, and differentiation of multicellular organisms are primarily driven by intercellular communication, which coordinates the activities of diverse cell types. This cell-to-cell signaling is typically mediated by various…
Somayeh Azadian, Javad Zahiri, Seyed Shahriar Arab, Reza Hassan sajedi
Intercellular interactions play an important role in regulating communications of cells with each other. So far, many studies have been done with both experimental and computational approaches in this field. Therefore, in order to investigate and analyze the intercellular interactions, use of network reconstruction has…
Tom Brandstätter, E.M. BRIEGER, David B. Brückner, Georg Ladurner + 2 more
governing collision behavior of distinct motile cells Authors: ['Tom Brandstätter' 'E.M. BRIEGER' 'David B. Brückner' 'Georg Ladurner' 'Joachim O. Rädler' 'Chase P. Broedersz'] The migration behavior of colliding cells is critically determined by transient contactinteractions. During these interactions, the motility…
Shambavi Ganesh, Beliz Utebay, Jeremy Heit, Ahmet F. Coskun
Advances in single-cell biotechnology have increasingly revealed interactions of cells with their surroundings, suggesting a cellular society at the microscale. Similarities between cells and humans across multiple hierarchical levels have quantitative inference potential for reaching insights about phenotypic…
Moriah Echlin, Boris Aguilar, Ilya Shmulevich, Alessandro Giuliani
Communication between cells enables the coordination that drives structural and functional complexity in biological systems. Both single and multicellular organisms have evolved diverse communication systems for a range of purposes, including synchronization of behavior, division of labor, and spatial organization.…
Tomohiro Minakawa, Tatsuya Katsuno, Keiko Okamoto-Furuta, Ryoko Ando + 8 more
Intercellular communication plays a central role in the development and integrity of multicellular organisms. Vesicle transfer, especially through extracellular space, has recently been highlighted as a critical intercellular communication modality, carrying nucleic acids, proteins, and others to distant cells.…
Agathe Jouneau, Tom Brandstätter, Bram Hoogland, Joachim O. Rädler + 1 more
In active matter and living matter, such as clusters of migrating cells, collective dynamics emerges from the underlying interactions. A common assumption of theoretical descriptions of collective cell migration is that these interactions are pairwise additive. It remains unclear, however, if the dynamics of groups of…
Kevin Troulé, Robert Petryszak, Batuhan Çakır, James Cranley + 6 more
'Alicia Harasty' 'Martin Prete' 'Zewen Kelvin Tuong' 'Sarah A. Teichmann' 'Luz García‐Alonso' 'Roser Vento‐Tormo'] Cell-cell communication is essential for tissue development, regeneration and function, and its disruption can lead to diseases and developmental abnormalities. The revolution of single-cell genomics…
Authors not listed
Chirality at the nanoscale has emerged as a powerful design parameter for engineering light-matter interactions, catalytic activity, and biological recognition. Among inorganic nanomaterials, plasmonic gold nanostructures are particularly attractive owing to their tunable optical resonances and compatibility with…
José A. Carrillo, Annachiara Colombi, Marco Scianna
- We demonstrate how concepts of statistical mechanics of interacting particles can have important implications in the choice of interaction potentials to model qualitative properties of cell aggregates in theoretical biology. We illustrate this by showing cell sorting phenomena for cell groups with different…
Jonathan E. Dawson, Abdul Naseer Malmi-Kakkada
Contact mediated cell-cell communication where direct physical contact between adjacent ligand cells and receptor cells trigger signal output is important during growth, development and regeneration of organisms. While the molecular machinery underlying contact mediated cell signaling is well explored, how the local…
Tongxia Jin, Luling Wu, Ti Jia, Rongrong Zhao + 6 more
Vicinal dithiol-containing proteins (VDPs) are of considerable importance due to their role in regulating cellular functions through the reversible dithiol/disulfide inter-conversion reaction. However, there are currently no effective tools for the simultaneous tracing of endogenous VDPs in live cells. Here, we report…
Authors not listed
Recent advances in cell-penetrating-peptide (CPP)-mediated intracellular protein delivery strategies have highlighted the importance of sustained membrane association to improve delivery efficiency. In this study, we report cell-surface-reactive, polyfluoroalkyl-tagged polyarginine peptides as CPP-additives with…
Zexi Xu, Michael Rappolt, Arwen Tyler, Paul Beales
Lipid nanoparticles have important applications as biomedical delivery platforms and broader engineering biology applications in artificial cell technologies. These emerging technologies often require changes in the shape and topology of biological or biomimetic membranes. Here we show that topologically-active…
Pierre-Henri Puech, Pierre Bongrand
How do cells process environmental cues to make decisions? This simple question is still generating much experimental and theoretical work, at the border of physics, chemistry and biology, with strong implications in medicine. The purpose of mechanobiology is to understand how biochemical and physical cues are turned…
Miriam Bassler, Jonas Hiller, Frank Wackenhut, Sven zur Oven-Krockhaus + 9 more
Malignant primary brain tumors are a group of highly aggressive and often infiltrating tumors that lack adequate therapeutic treatments to achieve long time survival. Complete tumor removal is one precondition to reach this goal. A promising approach to optimize resection margins and eliminate remaining infiltrative…