26 papers · ranked by Valyu relevance
Shadeeb Hossain
Bioelectrical properties of cells such as relative permittivity, conductivity, and characteristic time constants vary significantly between healthy and malignant cells across different frequencies. These distinctions provide a promising foundation for diagnostic and classification applications. This study…
Xinyue Chen, Amaleah Hartman, Xiao Hu, Anna E. Eastman + 3 more
Cancer is a hyper-proliferative clonal disease. Whether the proliferative state originates from the cell-of-origin or emerges later remains elusive. By tracking de novo transformation from normal hematopoietic progenitors expressing an acute myeloid leukemia (AML) oncogene MLL-AF9, we reveal that the cell cycle rate…
Iram Shazia Tyagi, Ho Yin Calvin Tsui, Si Chen, Xinyi Li + 9 more
Introduction Anti-mitosis has been a key strategy of anti-cancer therapies, targeting at a fundamental property of cancer cells, their non-controllable proliferation due to overactive mitotic divisions. For improved anti-cancer therapies, it is important to find out whether cancer cells can proliferate independent of…
Tattym E. Shaiken, Mohamad Siam, Joel M. Sederstrom, Padmini Narayanan
For decades cancer studies have focused on molecular genetics while the role of the cytoplasm has remained obscure. Separation of the viscous fluid cytosol and elastic-solid cytomatrix has offered an opportunity to solve an age-old mystery in biochemistry; how millions of complex chemical reactions can occur…
Manish Kumar
Cancer is a complex disease having a number of composite problems to be considered including cancer immune evasion, therapy resistance, and recurrence for a cure. Fundamentally, it remains a genetic disease as diverse aspects of the complexity of tumor growth and cancer development relate to its genetic machinery and…
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Lymphoid leukemia (LL) and lymphoma are two groups of neoplasms developed from lymphoid cells (LCs). To understand why different forms of LL/lymphoma occur at different ages, we analyzed the effects of different types of DNA changes on a LC and the cellular characteristics of LCs. Point DNA mutations (PDMs) and…
Annika Jögi, Marica Vaapil, Martin Johansson, Sven Påhlman
The differentiation stage of tumors is a central aspect in the histopathological classification of solid malignancies. The differentiation stage is strongly associated with tumor behavior, and generally an immature tumor is more aggressive than the more differentiated counterpart. While this is common knowledge in…
Kasper Karlsson, Moritz Przybilla, Hang Xu, Eran Kotler + 13 more
The earliest events during human tumor initiation are poorly characterized but may hold clues as to how to detect and prevent malignancy. Here we model occult pre-neoplasia by engineering TP53 deficiency, a common and early event in gastric cancer, into human gastric organoids. By performing experimental evolution in…
Helge Waldum, Geir Slupphaug
Malignancy manifests itself by deregulated growth and the ability to invade surrounding tissues or metastasize to other organs. These properties are due to genetic and/or epigenetic changes, most often mutations. Many aspects of carcinogenesis are known, but the cell of origin has been insufficiently focused on, which…
Yosuke Nagahata, Hiroshi Kawamoto
Cells forming malignant tumors are distinguished from those forming normal tissues based on several features: accelerated/dysregulated cell division, disruption of physiologic apoptosis, maturation/differentiation arrest, loss of polarity, and invasive potential. Among them, accelerated cell division and…
William B. Miller Jr., John S. Torday
Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition based evolution is suggested as an alternative approach to cancer development and progression in which…
Mikaela M. Mallin, Nicholas Kim, Mohammad Ikbal Choudhury, Se Jong Lee + 5 more
Although metastasis is the leading cause of cancer deaths, it is quite rare at the cellular level. Only a rare subset of cancer cells (∼1 in 1.5 billion) can complete the entire metastatic cascade: invasion, intravasation, survival in the circulation, extravasation, and colonization (i.e. are metastasis competent). We…
Yue Deng, Mingjing Li, Jinzhi Lei
Understanding how microenvironmental heterogeneity influences tumor progression is essential for advancing both cancer biology and therapeutic strategies. In this study, we develop a cellular automata (CA) model to simulate tumor growth under varying microenvironmental conditions and genetic mutation rates, addressing…
S. Sajedeh Mousavi, Sara Razi
Breast cancer is the most common cancer in women worldwide, and discovering the biomarkers of this disease became so vital nowadays and Cell in Cell structure could be one of them, and it may be used as an available proxy for tumour malignancy. (CICs) are unusual in that keep morphologically healthy cells within…
Laura El Nachef, Audrey Bouchet, Michel Bourguignon, Nicolas Foray + 2 more
'Brian Gabrielli' 'Yutaka Midorikawa'] Simple Summary The current theories of carcinogenesis are the result of a long succession of thoughts and beliefs since antiquity. From the humor theory that interpreted cancer as an excess of black bile to the three notions of initiation, promotion, and progression and the most…
Charlie George Barker, Eirini Petsalaki, Girolamo Giudice, Emmanuel Nsa Ekpenyong + 2 more
The morphology of breast cancer cells is often used as an indicator of tumour severity and prognosis. Additionally, morphology can be used to identify more fine-grained, molecular developments within a cancer cell, such as transcriptomic changes and signaling pathway activity. Delineating the interface between…
Stefania E. Kapsetaki, Luis H. Cisneros, Carlo C. Maley
Cells in obligately multicellular organisms by definition have aligned fitness interests, minimum conflict, and cannot reproduce independently. However, some cells eat other cells within the same body, sometimes called cell cannibalism. Such cell-in-cell events have not been thoroughly discussed in the framework of…
András Szabó, Roeland M. H. Merks
Cancer is a disease of cellular regulation, often initiated by genetic mutation within cells, and leading to a heterogeneous cell population within tissues. In the competition for nutrients and growth space within the tumors the phenotype of each cell determines its success. Selection in this process is imposed by both…
Xinlong Wang, Yilong Li, Jiating Li, Le Li + 7 more
'Rui Kong' 'Gang Wang' 'Yongwei Wang' 'Jisheng Hu' 'Bei Sun'] The term cell-in-cell, morphologically, refers to the presence of one cell within another. This phenomenon can occur in tumors but also among non-tumor cells. The cell-in-cell phenomenon was first observed 100 years ago, and it has since been found in a…
Hanieh Karimi, Paweł Moskal, Ewa Ł. Stępień
It was recently demonstrated that newly invented positronium imaging may be used for improving cancer diagnostics by providing additional information about tissue pathology with respect to the standardized uptake value currently available in positron emission tomography (PET). Positronium imaging utilizes properties of…
Miriam Bassler, Jonas Hiller, Frank Wackenhut, Sven zur Oven-Krockhaus + 9 more
Malignant primary brain tumors are a group of highly aggressive and often infiltrating tumors that lack adequate therapeutic treatments to achieve long time survival. Complete tumor removal is one precondition to reach this goal. A promising approach to optimize resection margins and eliminate remaining infiltrative…
Tesfay Tesfatsion, Arianna Collins, Giovanni Ramirez, Yousef Mzannar + 6 more
Cannabinoid receptors CB1 and CB2 are the primary endogenous receptors with which cannabinoids interact, inducing physiological and psychological effects. Although interactions with other receptors including TRPV1 and GPCR55, have been recognized in earlier studies, these interactions may play a significant role in…
Authors not listed
The WRN helicase has recently emerged as a promising therapeutic target for microsatellite instability (MSI)-high cancers. Here, we report LXW-P1, a potent WRN degrader derived from marine bromotyrosine alkaloids. Its molecular target was identified using an AI-guided, pathway-informed perturbation transcriptomics…
Rumiana Tenchov, Aparna Sapra, Janet Sasso, Krittika Ralhan + 3 more
Cancer is one of the leading causes of death worldwide. Early cancer detection is critical because it can significantly improve treatment outcome thus saving lives, reducing suffering, and lessening psychological and economic burdens. Cancer biomarkers provide varied information about cancer, from early detection of…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Authors not listed
Altered differentiation of blood cell precursors and their clonal expansion occurs in various types of leukaemia. One treatment strategy is to induce differentiation into the mature form, which is capable of undergoing apoptosis. It has been found that low doses of doxorubicin (DOX) induce phenotypic and morphological…