20 papers · ranked by Valyu relevance
Alexander Muacevic, John R Adler, Ana I Flores, Mitchell B Liester
Memory, a fundamental aspect of human cognition and consciousness, is multifaceted and extends beyond traditional conceptualizations of mental recall. This review article explores memory through various lenses, including brain-based, body-based, and cellular mechanisms. At its core, memory involves the encoding…
Yanfei Jiang, Zohreh AkhavanAghdam, Yutian Li, Brian M. Zid + 1 more
Cells can store memories of prior experiences to modulate their responses to subsequent stresses, as seen for the protein kinase A (PKA)-mediated general stress response in yeast, which is required for resistance against future stressful conditions. Using microfluidics and time-lapse microscopy, we quantitatively…
Paras Jain, Mohit Kumar Jolly, Jason T. George
Cells invariably encounter unpredictable changes in their microenvironment and undergo adaptation by orchestrating considerable alterations in their molecular states that often result in appreciable phenotypic changes. The timescale of molecular and, therefore, cellular adaptation depends on how quickly the memory of…
Christopher C. Price, Jairaj Mathur, Joel D. Boerckel, Amit Pathak + 1 more
Mechanotransduction describes activation of gene expression by changes in the cell’s physical microenvironment. Recent experiments show that mechanotransduction can lead to long-term “mechanical memory”, where cells cultured on stiff substrates for sufficient time (priming phase) maintain altered phenotype after…
Zacchari Ben Meriem, Yasmine Khalil, Pascal Hersen, Emmanuelle Fabre
Cellular memory is a critical ability displayed by microorganisms in order to adapt to potentially detrimental environmental fluctuations. In the unicellular eukaryote S. cerevisiae cellular memory can take the form of a faster or a decreased response following repeated stresses in cell population. Using microfluidics…
Tamás Veres, Márk Kerestély, Borbála M. Kovács, Dávid Keresztes + 5 more
'Klára Schulc' 'Erik Seitz' 'Zsolt Vassy' 'Dániel V. Veres' 'Péter Csermely'] Recent findings show that single, non-neuronal cells are also able to learn signalling responses developing cellular memory. In cellular learning nodes of signalling networks strengthen their interactions e.g. by the conformational memory of…
Jason T. George
Phenotypic adaptation is a core design feature of bacterial populations and multicellular systems navigating highly variable environments. Recent empirical data implicates the role of memory-driven decision-making in cellular systems navigating uncertain future nutrient environments based on prior experience, wherein a…
Mu-ming Poo, Michele Pignatelli, Tomás J. Ryan, Susumu Tonegawa + 15 more
'Tobias Bonhoeffer' 'Kelsey C. Martin' 'Andrii Rudenko' 'Li-Huei Tsai' 'Richard W. Tsien' 'Gord Fishell' 'Caitlin Mullins' 'J. Tiago Gonçalves' 'Matthew Shtrahman' 'Stephen T. Johnston' 'Fred H. Gage' 'Yang Dan' 'John Long' 'György Buzsáki' 'Charles Stevens'] The mechanism of memory remains one of the great unsolved…
Jingxin Li, Pavithran T. Ravindran, Aoife O’Farrell, Gianna T. Busch + 9 more
Cellular responses to environmental stimuli are typically thought to be governed by genetically encoded programs. We demonstrate that melanoma cells can form and maintain cellular memories during the acquisition of therapy resistance that exhibit characteristics of cellular learning and are dependent on the…
Adam Gosztolai, Mauricio Barahona
The response of microbes to external signals is mediated by biochemical networks with intrinsic time scales. These time scales give rise to a memory that impacts cellular behaviour. Here we study theoretically the role of cellular memory in Escherichia coli chemotaxis. Using an agent-based model, we show that cells…
Péter Csermely, Nina Kunšič, Péter Mendik, Márk Kerestély + 3 more
Molecular processes of neuronal learning have been well-described. However, learning mechanisms of non-neuronal cells have not been fully understood at the molecular level. Here, we discuss molecular mechanisms of cellular learning, including conformational memory of intrinsically disordered proteins and prions…
Sruthi Sridhar, Abdulrahman Khamaj, Manish Kumar Asthana
This paper explores memory from a cognitive neuroscience perspective and examines associated neural mechanisms. It examines the different types of memory: working, declarative, and non-declarative, and the brain regions involved in each type. The paper highlights the role of different brain regions, such as the…
de la Fuente, M Ildefonso
A large number of studies have shown the existence of metabolic covalent modifications in different molecular structures, able to store biochemical information that is not encoded by the DNA. Some of these covalent mark patterns can be transmitted across generations (epigenetic changes). Recently, the emergence of…
Ramón Alonso‐Sanz, Andrew Adamatzky
Commonly studied cellular automata are memoryless and have fixed topology of connections between cells. However by allowing updates of links and short-term memory in cells we may potentially discover novel complex regimes of spatio-temporal dynamics. Moreover by adding memory and dynamical topology to state update…
Jin-Hui Wang, Shan Cui
The acquisition, integration and storage of exogenous associated signals are termed as associative learning and memory. The consequences and processes of associative thinking and logical reasoning based on these stored exogenous signals can be memorized as endogenous signals, which are essential for decision making…
Oliver Hardt, Wayne S. Sossin
A number of observations in recent years demonstrates that across all levels of organization, memory is inherently fluid. On the cognitive-behavioral level, the innocent act of remembering can irrevocably alter the contents of established long-term memories, while the content of dormant long-term memories that is…
Hongzhe Wang, Junjie Wang, Shiqin Yan, Ruicheng Pan + 5 more
'Qi Yu' 'Tupei Chen' 'Lei Chen' 'Yang Liu'] Cellular automata (CA) are computational systems that exhibit complex global behavior arising from simple local rules, making them a fascinating candidate for various research areas. However, challenges such as limited flexibility and efficiency on conventional hardware…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in brain, along with neuroinflammation and synaptic dysfunction. Genetic…
Pierfrancesco Ombrini, Qidi Wang, Alexandros Vasileiadis, Fangting Wu + 6 more
Effective optimization and control of lithium-ion batteries cannot neglect the relation between fundamental physicochemical phenomena and performance. In this work, we apply a multi-step charging protocol to commercially relevant electrodes, such as LiNi0.8Mn0.1Co0.1O2 (NMC811), LiFePO4 (LFP), LiMn1.5Ni0.5O4 (LMNO)…