17 papers · ranked by Valyu relevance
Alexander Muacevic, John R Adler, Ana I Flores, Mitchell B Liester
Memory, a fundamental aspect of human cognition and consciousness, is multifaceted and extends beyond traditional conceptualizations of mental recall. This review article explores memory through various lenses, including brain-based, body-based, and cellular mechanisms. At its core, memory involves the encoding…
Schiller, Martin R.
This paper proposes an extension of the traditional Central Dogma of molecular biology to a more dynamic model termed the Central Dogma Cycle (CDC) and a broader network called the Central Dogma Cyclic Network (CDCN). While the Central Dogma is necessary for genetic information flow, it is not sufficient to fully…
Paras Jain, Mohit Kumar Jolly, Jason T. George
Cells invariably encounter unpredictable changes in their microenvironment and undergo adaptation by orchestrating considerable alterations in their molecular states that often result in appreciable phenotypic changes. The timescale of molecular and, therefore, cellular adaptation depends on how quickly the memory of…
Yoshikazu Endo, Haruki Nishio, Taichi Oguchi, Kyoko Yamane + 4 more
Some biological responses persist long after the initial stimulus has disappeared—a phenomenon known as cellular memory. In its long-term form, cellular memory often reflects interactions between cis-acting chromatin states and diffusible trans-acting regulators, which are experimentally difficult to separate in vivo.…
Tamás Veres, Márk Kerestély, Borbála M. Kovács, Dávid Keresztes + 5 more
'Klára Schulc' 'Erik Seitz' 'Zsolt Vassy' 'Dániel V. Veres' 'Péter Csermely'] Recent findings show that single, non-neuronal cells are also able to learn signalling responses developing cellular memory. In cellular learning nodes of signalling networks strengthen their interactions e.g. by the conformational memory of…
Jason T. George
Phenotypic adaptation is a core design feature of bacterial populations and multicellular systems navigating highly variable environments. Recent empirical data implicates the role of memory-driven decision-making in cellular systems navigating uncertain future nutrient environments based on prior experience, wherein a…
Jingxin Li, Pavithran T. Ravindran, Aoife O’Farrell, Gianna T. Busch + 9 more
Cellular responses to environmental stimuli are typically thought to be governed by genetically encoded programs. We demonstrate that melanoma cells can form and maintain cellular memories during the acquisition of therapy resistance that exhibit characteristics of cellular learning and are dependent on the…
Etienne Guichard, Felix Reimers, Mia Kvalsund, Mikkel Lepperød + 1 more
'Stefano Nichele'] This study introduces EngramNCA, a neural cellular automaton (NCA) that integrates both publicly visible states and private, cell-internal memory channels, drawing inspiration from emerging biological evidence suggesting that memory storage extends beyond synaptic modifications to include…
F. Sevlever
In the context of cellular signaling and gene regulatory networks, the concept of molecular memory emerges as a crucial determinant of molecular mechanisms. This study introduces a novel memory quantifier designed to comprehensively capture and quantify the memory of a system in response to transient stimuli. We…
Sruthi Sridhar, Abdulrahman Khamaj, Manish Kumar Asthana
This paper explores memory from a cognitive neuroscience perspective and examines associated neural mechanisms. It examines the different types of memory: working, declarative, and non-declarative, and the brain regions involved in each type. The paper highlights the role of different brain regions, such as the…
Jacob A. Berry, Dana C. Guhle, Ronald L. Davis
Recent and pioneering animal research has revealed the brain utilizes a variety of molecular, cellular, and network-level mechanisms used to forget memories in a process referred to as “active forgetting”. Active forgetting increases behavioral flexibility and removes irrelevant information. Individuals with impaired…
Daniel Szelogowski
Despite substantial research into the biological basis of memory, the precise mechanisms by which experiences are encoded, stored, and retrieved in the brain remain incompletely understood. A growing body of evidence supports the engram theory, which posits that sparse populations of neurons undergo lasting physical…
Axel Guskjolen, Mark S. Cembrowski
Tremendous strides have been made in our understanding of the neurobiological substrates of memory - the so-called memory “engram”. Here, we integrate recent progress in the engram field to illustrate how engram neurons transform across the “lifespan” of a memory - from initial memory encoding, to consolidation and…
Samuel J. Gershman
The most widely accepted view of memory in the brain holds that synapses are the storage sites of memory, and that memories are formed through associative modification of synapses. This view has been challenged on conceptual and empirical grounds. As an alternative, it has been proposed that molecules within the cell…
Hongzhe Wang, Junjie Wang, Shiqin Yan, Ruicheng Pan + 5 more
'Qi Yu' 'Tupei Chen' 'Lei Chen' 'Yang Liu'] Cellular automata (CA) are computational systems that exhibit complex global behavior arising from simple local rules, making them a fascinating candidate for various research areas. However, challenges such as limited flexibility and efficiency on conventional hardware…
Luz Bavassi, Lluís Fuentemilla
What dynamics characterize the transformation of memories over time? Here we introduce a neural network formalization that reveals that memory representations undergo a transition from highly segregated to richly integrated network forms, driven by a combination of neural network reactivations, spreading, and synaptic…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…