20 papers · ranked by Valyu relevance
Aske L. Ejdrup, Matthew D. Lycas, Niels Lorenzen, Ainoa Konomi + 3 more
Dual-color single-molecule localization microscopy (SMLM) provides unprecedented possibilities for detailed studies of colocalization of different molecular species in a cell. However, the informational richness of the data is not fully exploited by current analysis tools that often reduce colocalization to a single…
Yasuhiro Kojima, Shinji Mii, Shuto Hayashi, Haruka Hirose + 4 more
Analyzing colocalization of single cells with heterogeneous molecular phenotypes is essential for understanding cell-cell interactions, cellular responses to external stimuli, and their biological functions in diseases and tissues. However, high-throughput methods for identifying spatial proximity at single-cell…
Manuel Seefelder, Stefan Kochanek, Fabrice A. C. Klein
Colocalization, the spatial overlap of molecular entities, is often key to support their involvement in common functions. Existing colocalization tools, however, face limitations, particularly because of their basic statistical analysis and their low-throughput manual entry processes making them unsuitable for…
Julia Naas, Giacomo Nies, Housen Li, Stefan Stoldt + 3 more
With recent advances in multi-color super-resolution light microscopy it has become possible to simultaneously visualize multiple subunits within complex biological structures at nanometer resolution. To opti-mally evaluate and interpret spatial proximity of stainings on such an image, colocalization analysis tools…
Julia Naas, Giacomo Nies, Housen Li, Stefan Stoldt + 3 more
'Bernhard Schmitzer' 'Stefan Jakobs' 'Axel Munk'] With recent advances in multi-color super-resolution light microscopy, it is possible to simultaneously visualize multiple subunits within biological structures at nanometer resolution. To optimally evaluate and interpret spatial proximity of stainings on such an image…
Aske L. Ejdrup, Matthew D. Lycas, Niels Lorenzen, Ainoa Konomi + 3 more
'Freja Herborg' 'Kenneth L. Madsen' 'Ulrik Gether'] Dual-color single-molecule localization microscopy (SMLM) provides unprecedented possibilities for detailed studies of colocalization of different molecular species in a cell. However, the informational richness of the data is not fully exploited by current analysis…
Luciano da Fontoura Costa
Given two or more concentrations, an interesting and important related issue concerns the quantification of how strongly they are spatially interrelated. The concept of colocalization has been frequently considered as an indication of the tendency of the values of two concentrations to spatially vary together. While…
Wenmin Zhang, Tianyuan Lu, Robert Sladek, Yue Li + 2 more
Colocalization analysis is commonly used to assess whether two or more traits share the same genetic signals identified in genome-wide association studies (GWAS), and is important for prioritizing targets for functional follow-up of GWAS results. Existing colocalization methods can have suboptimal performance when…
Jan Rhomberg-Kauert, Max Karlsson, Divya Thiagarajan, Tomasz Kallas + 4 more
'Filip Karlsson' 'Simon Fredriksson' 'Johan Dahlberg' 'Alvaro Martinez Barrio'] Advances in spatial proteomics and protein colocalization are a driving force in the understanding of cellular mechanisms and their influence on biological processes. New methods in the field of spatial proteomics call for the development…
Wenmin Zhang, Tianyuan Lu, Robert Sladek, Yue Li + 3 more
Colocalization analysis is a commonly used statistical procedure to assess whether two or more traits share the same genetic signals identified in genome-wide association studies (GWAS) (, , , , , ). It is important for understanding the interplay between heritable traits (, ), such as validating causal inference…
Tongwu Zhang, Alyssa Klein, Jian Sang, Jiyeon Choi + 1 more
Genome-wide association studies (GWAS) have identified thousands of genomic loci associated with complex diseases and traits, including cancer. The vast majority of common trait-associated variants identified via GWAS fall in non-coding regions of the genome, posing a challenge in elucidating the causal variants…
Leonid Positselski
This paper is a commutative algebra introduction to the homological theory of quasi-coherent sheaves and contraherent cosheaves over quasi-compact semi-separated schemes. Antilocality is an alternative way in which global properties are locally controlled in a finite affine open covering. For example, injectivity of…
Seongwon Hwang, Jeffrey Pullin, Chris Wallace, John Whittaker + 1 more
Colocalization is frequently performed as a step to triage findings from genetic investigations linking molecular and disease data. However, the reliability and consistency of the various colocalization methods is not well understood. In particular, it is unclear whether a non-colocalization result should be taken as a…
Zulzikry Hafiz Abu Bakar, Jean-Pierre Bellier, Wan Zurinah Wan Ngah, Daijiro Yanagisawa + 3 more
'Daijiro Yanagisawa' 'Ken-ichi Mukaisho' 'Ikuo Tooyama' 'J. Bernard Heymann'] The precision of colocalization analysis is enhanced by 3D and is potentially more accurate than 2D. Even though 3D improves the visualization of colocalization analysis, rendering a colocalization model may generate a model with numerous…
Ashish Patel, John C. Whittaker, Stephen Burgess
relevant genetic variants Authors: ['Ashish Patel' 'John C. Whittaker' 'Stephen Burgess'] Colocalization analyses assess whether two traits are affected by the same or distinct causal genetic variants in a single gene region. A class of Bayesian colocalization tests (Giambartolomei et al., 2014; Wallace, 2021) are now…
Authors not listed
Quantitative analysis of small extracellular vesicles (sEVs) at single-particle resolution remains challenging due to their nanoscale dimensions and compositional heterogeneity. Existing methods often rely on specialized and costly instrumentation, limiting accessibility for many researchers and necessitates extensive…
Sándor Juhász, Zoltán Elekes, Virág Ilyés, Frank Neffke
using firm-to-firm network data Authors: ['Sándor Juhász' 'Zoltán Elekes' 'Virág Ilyés' 'Frank Neffke'] Strong local clusters help firms compete on global markets. One explanation for this is that firms benefit from locating close to their suppliers and customers. However, the emergence of global supply chains shows…
Sneha Ramshanker, Hungtang Ko, Radhika Nagpal
Inspection Productivity Authors: ['Sneha Ramshanker' 'Hungtang Ko' 'Radhika Nagpal'] > Abstract. Robot swarms offer significant potential for inspecting diverse infrastructure, ranging from bridges to space stations. However, effective inspection requires accurate robot localization, which demands substantial…
Benno Liebchen, Aritra K. Mukhopadhyay
The past two decades have seen a remarkable progress in the development of synthetic colloidal agents which are capable of creating directed motion in an unbiased environment at the microscale. These self-propelling particles are often praised for their enormous potential to self-organize into dynamic nonequilibrium…
Xia Wang, Zeyu Liu, Jiaojiao Wang, Tian Lu + 3 more
The stable precursor C18Br6 is of more practical significance than the refreshing but elusive cyclo[18]carbon (C18) at present, and molecular aromaticity caused by π-electron delocalization is an important issue of interest for this unusual molecule. In this paper, the electronic structure and bonding character of the…