25 papers · ranked by Valyu relevance
Francesco Pagano, Luca Verderame, Alessio Merlo
—Fuchsia is a new open-source operating system created at Google that is currently under active development. The core architectural principles guiding the design and development of the OS include high system modularity and a specific focus on security and privacy. This paper analyzes the architecture and the software…
Ludger Jansen, Stefan Schulz
Background In biomedical ontologies, mereological relations have always been subject to special interest due to their high relevance in structural descriptions of anatomical entities, cells, and biomolecules. This paper investigates two important subrelations of has_proper_part, viz. the relation has_grain, which…
Michael A. Filler, Benjamin Reinhardt
The process of using light and chemicals to construct microelectronics from a single piece of silicon has both enabled Moore's Law and created many unfortunate downstream effects: industry consolidation in volatile parts of the world, fragile supply chains, high overhead for making custom circuits, and large barriers…
Tauseef Rana, Abdullah Baz
The availability of smart and intelligent sensors has changed the monitoring, control and maintenance of a conventional and advanced cyber-physical system used in public or private sectors of a society. For example, internet of things (IoT)-based health, agricultural and weather management systems. With the emergence…
Tauseef Rana, Yawar Abbas Bangash, Abdullah Baz, Toqir Ahmad Rana + 1 more
'Muhammad Ali Imran'] Cyber-physical systems (CPS) are composed of software and hardware components. Many such systems (e.g., IoT based systems) are created by composing existing systems together. Some of these systems are of critical nature, e.g., emergency or disaster management systems. In general, component-based…
Basem Y. Alkazemi
Utilizing third party software components in thedevelopment of new systems became somewhat unfavourableapproach among many organizations nowadays. This reluctance is primarily built due to the lack of support to verify the quality attributes of software components in order to avoid potential mismatches with system€s…
Andrew Harvie, John de Mello
The Open Polarimeter (“Opol”) is a phase-based, high-resolution laser polarimeter formed from a small number of inexpensive optomechanical parts. The complete instrument can be assembled from scratch in two days for less than US$250, using only a 3D-printer and a benchtop milling machine. However despite its low cost…
Maedeh Mohebnasab, Oskar Eriksson, Barbro Persson, Kerstin Sandholm + 5 more
'Camilla Mohlin' 'Markus Huber-Lang' 'Brendan J. Keating' 'Kristina N. Ekdahl' 'Bo Nilsson'] Aberrations in complement system functions have been identified as either direct or indirect pathophysiological mechanisms in many diseases and pathological conditions, such as infections, autoimmune diseases, inflammation…
Cyrus Khalatbari
This contribution follows a four-year investigation (2022--2026) into the political economy of graphics card miniaturization. It begins from the premise that rethinking our relationship to artificial intelligence and its sociotechnical entanglements requires demystifying and opening the black box of this technical…
Bo Yong, Zixiang Luo, Bo Luo, Jinbo Liu + 2 more
The complement system bridges innate and adaptive immunity, orchestrating immune surveillance and maintaining tissue homeostasis. This review summarizes the role of the complement system in gastrointestinal-related diseases, including its function in innate immunity, impact on adaptive immunity, and regulatory role…
Dhivya Kumar, Addison Rains, Vicente Herranz-Pérez, Quanlong Lu + 9 more
Cells inherit two centrioles, the older of which is uniquely capable of generating a cilium. We identified that three evolutionarily conserved proteins that underlie human ciliopathies, CEP90, MNR and OFD1, form a complex. This complex localized to both distal centrioles and centriolar satellites, proteinaceous…
Authors not listed
The study demonstrates the capabilities of a vector-based approach for calculating stoichiometric coefficients in chemical equations, using black powder as an illustrative example. A method is proposed for selecting and constraining intermediate interactions between reactants, as well as for identifying final products.…
Christoph Karfusehr, Markus Eder, Friedrich C. Simmel
DNA origami provides a methodology for the sequence-programmable generation of precisely defined molecular nanostructures with sizes of order 100 nm. A new frontier for the field is the generation of superstructures made from DNA origami subunits, which requires other self-assembly strategies than those used for DNA…
Mariam T. Heggi, Hanzada T. Nour El-Din, Dina I. Morsy, Noha I. Abdelaziz + 1 more
'Noha I. Abdelaziz' 'Ahmed S. Attia'] The complement system is a fundamental part of the innate immune system that plays a key role in the battle of the human body against invading pathogens. Through its three pathways, represented by the classical, alternative, and lectin pathways, the complement system forms a…
Mariano Salgueiro, Gabriela Camporeale, Araceli Visentin, Martin Aran + 8 more
Viral factories of liquid-like nature host transcription and replication in most viruses. The syncytial respiratory virus factories include gene function proteins, brought together by the phosphoprotein (P) RNA polymerase cofactor, present across non-segmented negative stranded RNA viruses. Homotypic liquid-liquid…
Amit Patel, Rahul Sharma
The human immune system is a complex network of cells, tissues, and organs that work together to protect the body from harmful pathogens. Antibodies, also known as immunoglobulins (Ig), are small proteins that play a vital role in the immune system's defense mechanism. Among the five classes of immunoglobulins…
Luyao Li, Rong Zhang, Xintong Tian, Ting Li + 9 more
The compartmentalized and communicative nature of biological cells contributes to the complexity and endurance of living organisms. Current in vitro compartmentalization systems such as droplet emulsions reproduce the compartmentalization property of cells yet fail to recapture the configurability of cellular…
Authors not listed
Molecular mechanisms governing initiation steps of the assembly of thousands of endogenous multi-protein complexes (EMCs) remain incompletely understood. Here, multiple lines of observations are reported reflecting the biological functions-aligned initiation sequence of hybrid assembly pathways (HAPs) of EMCs. HAPs…
Authors not listed
Self-organizing tissues, such as organoids, offer transformative potential beyond healthcare by enabling the sustainable production of advanced materials. Resource scarcity and global warming drive the need for innovative fabrication solutions. This prospective review explores developmental biology as a manufacturing…
Hani Nasser Abdelhamid
This review summarizes applications of some of the advanced materials. It included the synthesis of several nanoparticles such as metal oxide nanoparticles (e.g., Fe3O4, ZnO, ZrOSO4, MoO3-x, CuO, AgFeO2, Co3O4, CeO2, SiO2, and CuFeO2); metal hydroxide nanosheets (e.g., Zn5(OH)8(NO3)2·2H2O, Zn(OH)(NO3)·H2O, and…
P. Bordalo, A. S. Nunes, C. Menezes Pires, C. Quintans + 1 more
—The Detector Control System (DCS) of the COM-PASS experiment at CERN is presented. The experiment has a high level of complexity and flexibility and a long time of operation, that constitute a challenge for its full monitorisation and control. A strategy to use a limited number of standardised, cost-effective…
Ahanjit Bhattacharya, Henrike Niederholtmeyer, Kira A. Podolsky, Rupak Bhattacharya + 5 more
Living cells segregate molecules and reactions in various subcellular compartments and locations. Spatial organization is likely essential for expanding the biochemical functions of synthetic reaction systems, including artificial cells. Here we describe programmable synthetic organelles based on highly stable lipid…
Felix Sigmund, Christoph Massner, Philipp Erdmann, Anja Stelzl + 9 more
We have genetically controlled compartmentalization in eukaryotic cells by heterologous expression of bacterial encapsulin shell and cargo proteins to engineer enclosed enzymatic reactions and size-controlled metal biomineralization. The orthogonal shell protein (EncA) from M. xanthus efficiently auto-assembled inside…
Diana A. Tanase, Layla Malouf, Roger Rubio-Sánchez, Karan Jain + 2 more
Cells use a combination of membrane-bound and membrane-less compartments to dynamically orchestrate internal biochemical processes and sustain intracellular communication. Recapitulating the hierarchical integration and interplay between these physically and chemically diverse structures is required to enhance the…
A. Buccheri, M. Capodiferro, S. Morganti, F. Orio + 2 more
'V. Pettinacci'] The 19 towers constituting the CUORE detector are an assembly of ultra-radio-pure components made of copper and PTFE plus tellurium dioxide crystals for a total of more than 10,000 pieces. A dedicated assembly line is mandatory to handle and assemble those parts and to minimize the risk of…