26 papers · ranked by Valyu relevance
Michael A. Filler, Benjamin Reinhardt
The process of using light and chemicals to construct microelectronics from a single piece of silicon has both enabled Moore's Law and created many unfortunate downstream effects: industry consolidation in volatile parts of the world, fragile supply chains, high overhead for making custom circuits, and large barriers…
Authors not listed
Vaccination is a highly efficient strategy in controlling infections. Aluminum-containing adjuvants have long been used to enhance immunogenicity, but quantification of adsorbed antigens remains analytically challenging. This study uses Raman spectroscopy, a powerful, non-destructive technique, augmented by machine…
Runzi Zheng, Yanghuan Zhang, Ke Zhang, Yang Yuan + 4 more
'Jing Liu' 'Darío Acuña-Castroviejo' 'Eleni Gavriilaki'] The complement system is a part of the immune system and consists of multiple complement components with biological functions such as defense against pathogens and immunomodulation. The complement system has three activation pathways: the classical pathway, the…
Manuel Adrián Velázquez-Cervantes, Yazmín Rocío Benítez-Zeferino, Arturo Flores-Pliego, Addy Cecilia Helguera-Repetto + 8 more
'Arturo Flores-Pliego' 'Addy Cecilia Helguera-Repetto' 'David Eduardo Meza-Sánchez' 'José Luis Maravillas-Montero' 'Guadalupe León-Reyes' 'Javier Mancilla-Ramírez' 'Jorge Francisco Cerna-Cortés' 'María Isabel Baeza-Ramírez' 'Moises León-Juaárez' 'Yong Weon Yi'] Cellular communication depends heavily on the…
Authors not listed
The study demonstrates the capabilities of a vector-based approach for calculating stoichiometric coefficients in chemical equations, using black powder as an illustrative example. A method is proposed for selecting and constraining intermediate interactions between reactants, as well as for identifying final products.…
Tilo Freiwald, Behdad Afzali
The complement system is a highly conserved and essential immune component with pivotal roles in innate and adaptive immunity. It is increasingly recognized that the complement system has a profound impact on disease. Current complement-targeting therapeutics for clinical use almost exclusively target the complement…
Camila Mori de Oliveira, Rossana Bellopede, Alice Tori, Giovanna Zanetti + 3 more
'Giovanna Zanetti' 'Paola Marini' 'Dimitra Vernardou' 'Damon Kent'] This study proposed an evaluation of enrichment processes of obsolete Printed Circuit Boards (PCBs), by means of gravity and electrostatic separation, aiming at the recovery of metals. PCBs are the most important component in electronic devices, having…
Cyrus Khalatbari
This contribution follows a four-year investigation (2022--2026) into the political economy of graphics card miniaturization. It begins from the premise that rethinking our relationship to artificial intelligence and its sociotechnical entanglements requires demystifying and opening the black box of this technical…
Bo Yong, Zixiang Luo, Bo Luo, Jinbo Liu + 2 more
The complement system bridges innate and adaptive immunity, orchestrating immune surveillance and maintaining tissue homeostasis. This review summarizes the role of the complement system in gastrointestinal-related diseases, including its function in innate immunity, impact on adaptive immunity, and regulatory role…
Christoph Karfusehr, Markus Eder, Friedrich C. Simmel
DNA origami provides a methodology for the sequence-programmable generation of precisely defined molecular nanostructures with sizes of order 100 nm. A new frontier for the field is the generation of superstructures made from DNA origami subunits, which requires other self-assembly strategies than those used for DNA…
Mariam T. Heggi, Hanzada T. Nour El-Din, Dina I. Morsy, Noha I. Abdelaziz + 1 more
'Noha I. Abdelaziz' 'Ahmed S. Attia'] The complement system is a fundamental part of the innate immune system that plays a key role in the battle of the human body against invading pathogens. Through its three pathways, represented by the classical, alternative, and lectin pathways, the complement system forms a…
Yan Zeyu, Hong, SuHwan, Hester + 4 more
We introduce DissolvPCB, an electronic prototyping technique for fabricating fully recyclable printed circuit board assemblies (PCBAs) using affordable FDM 3D printing, with polyvinyl alcohol (PVA) as a water-soluble substrate and eutectic gallium-indium (EGaIn) as the conductive material. When obsolete, the PCBA can…
Luyao Li, Rong Zhang, Xintong Tian, Ting Li + 9 more
The compartmentalized and communicative nature of biological cells contributes to the complexity and endurance of living organisms. Current in vitro compartmentalization systems such as droplet emulsions reproduce the compartmentalization property of cells yet fail to recapture the configurability of cellular…
Zeyu Yan, Jiasheng Li, Zining Zhang, Huaishu Peng
promote the recycling and reuse of electronic components. Central to this approach are custom 3D-printable housings that allow SMD components to be mounted onto PCBs without soldering. We detail the design of SolderlessPCB and the experiments conducted to evaluate its design parameters, electrical performance, and…
Mariano Salgueiro, Gabriela Camporeale, Araceli Visentin, Martin Aran + 8 more
Viral factories of liquid-like nature host transcription and replication in most viruses. The syncytial respiratory virus factories include gene function proteins, brought together by the phosphoprotein (P) RNA polymerase cofactor, present across non-segmented negative stranded RNA viruses. Homotypic liquid-liquid…
Carlos Antón-Plágaro, Kai-en Chen, Qian Guo, Meihan Liu + 6 more
Endosomal retrieval and recycling of integral cargo proteins is essential for cell, tissue and organism-level development and homeostasis and is orchestrated through a specialised retrieval sub-domain on the endosomal vacuole. However, although sub-domain dysfunction is associated with human disease our appreciation of…
Yan Zeyu, Hong, SuHwan, Hester + 4 more
We introduce DissolvPCB, an electronic prototyping technique for fabricating fully recyclable printed circuit board assemblies (PCBAs) using affordable FDM 3D printing, with polyvinyl alcohol (PVA) as a water-soluble substrate and eutectic gallium-indium (EGaIn) as the conductive material. When obsolete, the PCBA can…
Amit Patel, Rahul Sharma
The human immune system is a complex network of cells, tissues, and organs that work together to protect the body from harmful pathogens. Antibodies, also known as immunoglobulins (Ig), are small proteins that play a vital role in the immune system's defense mechanism. Among the five classes of immunoglobulins…
Authors not listed
Molecular mechanisms governing initiation steps of the assembly of thousands of endogenous multi-protein complexes (EMCs) remain incompletely understood. Here, multiple lines of observations are reported reflecting the biological functions-aligned initiation sequence of hybrid assembly pathways (HAPs) of EMCs. HAPs…
Yan Zeyu, Hong, SuHwan, Hester + 4 more
We introduce DissolvPCB, an electronic prototyping technique for fabricating fully recyclable printed circuit board assemblies (PCBAs) using affordable FDM 3D printing, with polyvinyl alcohol (PVA) as a water-soluble substrate and eutectic gallium-indium (EGaIn) as the conductive material. When obsolete, the PCBA can…
Alexander Muacevic, John R Adler, Samuel Sherng Young Wang, Haoming Tang + 3 more
'Haoming Tang' 'Marcus Wing Choy Loe' 'See Cheng Yeo' 'Muhammad M Javaid'] The complement system is critical to the body's innate defense against exogenous pathogens and clearance of endogenous waste, comprising the classical, alternative, and lectin pathways. Although tightly regulated, various congenital and acquired…
Yoshitaka Kurikawa, Ikuko Koyama-Honda, Keiko Igarashi, Norito Tamura + 2 more
Organelles have unique structures and molecular compositions for their functions and have been classified accordingly. However, many organelles are heterogeneous and in the process of maturation and differentiation. Because traditional methods have a limited number of parameters and spatial resolution, they struggle to…
Authors not listed
Self-organizing tissues, such as organoids, offer transformative potential beyond healthcare by enabling the sustainable production of advanced materials. Resource scarcity and global warming drive the need for innovative fabrication solutions. This prospective review explores developmental biology as a manufacturing…
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The advancement of the cell-culture industry toward a circular bioeconomy is driving a growing demand for simple and cost-effective analytical technologies to support the quality control of culture media. Here, we present a hypothesis-free, data-driven sensing strategy that employs an array of synthetic polymer probes…
Jennifer M. Kefauver, Markku Hakala, Luoming Zou, Josephine Alba + 7 more
Biological membranes are partitioned into functional zones containing specific lipids and proteins, termed membrane microdomains. Their composition and organization remain controversial owing to a paucity of techniques that can visualize lipids in situ without disrupting their native behavior^1,2^. The yeast eisosome…
Wangjie Tu, Rachel Q. Theisen, Pengfei Jin, David M. Chenoweth + 2 more
Cells contain membrane-bound and membraneless organelles that operate as spatially distinct biochemical niches. However, these reaction centers lose fidelity due to aging or disease. A grand challenge for biomedicine is restoring or augmenting cellular functionalities. Although commonly tackled by gene replacement…