19 papers · ranked by Valyu relevance
Michael B. Sohn, Hongzhe Li
Motivated by advances in the causal inference in mediation analysis and problems arising in the analysis of metagenomic data, we consider the effect of treatment on an outcome transmitted through compositional mediators. Compositional and high dimensional features of such mediators make the standard mediation analysis…
Noora Kartiosuo, Jaakko Nevalainen, Olli T. Raitakari, Katja Pahkala + 1 more
'Kari Auranen'] Biological sequencing data consist of read counts, e.g. of specified taxa and often exhibit sparsity (zero-count inflation) and overdispersion (extra-Poisson variability). As most sequencing techniques provide an arbitrary total count, taxon-specific counts should ideally be treated as proportions under…
Jingyan Fu, Matthew D. Koslovsky, Andreas M. Neophytou, Marina Vannucci
'Marina Vannucci'] Analyzing multivariate count data generated by high-throughput sequencing technology in microbiome research studies is challenging due to the high-dimensional and compositional structure of the data and overdispersion. In practice, researchers are often interested in investigating how the microbiome…
Chan Wang, Jiyuan Hu, Martin J. Blaser, Huilin Li
Recent microbiome association studies have revealed important associations between microbiome and disease/health status. Such findings encourage scientists to dive deeper to uncover the causal role of microbiome in the underlying biological mechanism, and have led to applying statistical models to quantify causal…
Quran Wu, James O’Malley, Susmita Datta, Raad Z. Gharaibeh + 8 more
'Christian Jobin' 'Margaret R. Karagas' 'Modupe O. Coker' 'Anne G. Hoen' 'Brock C. Christensen' 'Juliette C. Madan' 'Zhigang Li' 'Yi-Juan Hu'] Background: The human microbiome can contribute to pathogeneses of many complex diseases by mediating disease-leading causal pathways. However, standard mediation analysis…
Tamara Schamberger, Florian Schuberth, Jörg Henseler
Moderated mediation models are crucial in many disciplines, particularly the social sciences. Researchers use them to analyze the conditions under which different variables are related. Structural equation modeling (SEM) is an eminently suitable framework for this endeavor. In fact, several approaches have been…
Hanying Jiang, Xinran Miao, Margaret W. Thairu, Mara Beebe + 4 more
Mediation analysis has emerged as a versatile tool for answering mechanistic questions in microbiome research because it provides a statistical framework for attributing treatment effects to alternative causal pathways. Using a series of linked regression models, this analysis quantifies how complementary data…
Boris HJM Brummans, Lise Higham, François Cooren
Mediation is a widely used form of third-party conflict management for which research has primarily focused on the role of mediators. But how are the relations between disputing parties constituted in communication involving written texts, such as official letters or medical reports, during mediation sessions? To gain…
Stephanie Wankowicz, James Fraser
In their folded state, biomolecules exchange between multiple conformational states, crucial for their function. However, most structural models derived from experiments and computational predictions only encode a single state. To represent biomolecules more accurately, we must move towards modeling and predicting…
Wesley L. Crouse, Gregory R. Keele, Madeleine S. Gastonguay, Gary A. Churchill + 2 more
'Gary A. Churchill' 'William Valdar' 'Zoltán Kutalik'] Genetic studies often seek to establish a causal chain of events originating from genetic variation through to molecular and clinical phenotypes. When multiple phenotypes share a common genetic association, one phenotype may act as an intermediate for the genetic…
RD Pascual-Marqui, P Faber, S Ikeda, R Ishii + 6 more
In a seminal paper by von Stein and Sarnthein (200), it was hypothesized that “bottom-up” information processing of “content” elicits local, high frequency (beta-gamma) oscillations, whereas “top-down” processing is “contextual”, characterized by large scale integration spanning distant cortical regions, and…
Tomas Trescak, Carles Sierra, Simeon Simoff, Ramón López de Mántaras
Mediation is a process, in which both parties agree to resolve their dispute by negotiating over alternative solutions presented by a mediator. In order to construct such solutions, mediation brings more information and knowledge, and, if possible, resources to the negotiation table. The contribution of this paper is…
Stephanie Wankowicz, James Fraser
In their folded state, biomolecules exchange between multiple conformational states, crucial for their function. However, most structural models derived from experiments and computational predictions only encode a single state. To represent biomolecules more accurately, we must move towards modeling and predicting…
Sungwon In, Eric Krokos, Kirsten Whitley, Chris North + 1 more
The following sections present quantitative results across the conditions, see Fig. 6 and Fig. 7. Time: Completion time was significantly affected by the Compositional (\\\*). A linear mixed-effects model showed a significant effect of condition, = −0.88, = 0.11, 2 (1) = 28.38, < 0.0001. Pairwise comparisons also…
Johan Unge, Jieye Lin, Sara J Weaver, Ampon Sae Her + 1 more
MicroED is an effective method for analyzing the structural properties of sub-micron crystals, which are frequently found in small-molecule powders. By developing and using an autonomous and high throughput approach to MicroED, we demonstrate the expansion of capabilities and the possibility of performing complete…
Wenrong Lin, Zheng Jye Ling, Siqi Liu, Joel Tye Beng Lee + 7 more
'Marcus Lim' 'Aloysius Goh' 'Sean Lim' 'Peter George Manning' 'Mengling Feng' 'Tze Ping Loh' 'Lars-Peter Kamolz'] Healthcare delivery is a highly complex, deeply personal and costly endeavour that involves multiple specialties and services. There is an imbalance in knowledge between the healthcare provider and consumer…
Hagit Peres, Rachel Sharaby
Background Reduction of health gaps between ethno-cultural groups has become a major concern for health services, with a strong emphasis on eliminating social and cultural barriers and improving accessibility for diverse populations. Methods The study is based on a Participatory Action Research where an involved…
Thomas H. Weisswange, Hifza Javed, Manuel Dietrich, Malte Jung + 1 more
Interactions through Directed Robot Action using an Extended Group Process Model Authors: ['Thomas H. Weisswange' 'Hifza Javed' 'Manuel Dietrich' 'Malte Jung' 'Nawid Jamali'] Group processes refer to the dynamics that occur within a group and are critical for understanding how groups function. With robots being…
Authors not listed
Redox-mediated flow batteries (RMFBs) promise increased energy density through the incorporation of solid active materials into the external tanks, but the operation and design of these devices is challenged by kinetic, thermodynamic, and transport complexities introduced by the solid-mediator reactions. Here, we…