19 papers · ranked by Valyu relevance
Yang Zhang, Dirk Bucher, Farzan Nadim
Conduction delay in axons is a function of the axon morphology, passive membrane properties and voltage-gated ionic currents. Although conduction delay is usually assumed to be constant, indicating perfect temporal fidelity, recent work has shown that the delay of each action potential depends on the prior short- and…
Yang Zhang, Dirk Bucher, Farzan Nadim, Frances K Skinner
Axonal conduction velocity can change substantially during ongoing activity, thus modifying spike interval structures and, potentially, temporal coding. We used a biophysical model to unmask mechanisms underlying the history-dependence of conduction. The model replicates activity in the unmyelinated axon of the…
Bum-Rak Choi, Ohad Ziv, Guy Salama
Background and significance The specialized conduction system (SCS) of the heart was extensively studied to understand the synchronization of atrial and ventricular contractions, the large atrial to His bundle (A-H) delay through the atrioventricular node (AVN), and delays between Purkinje (P) and ventricular (V)…
Michael Ryne Horn, Nathaniel Liam Lazorchak, Usama Kalim Khan, Ken Yoshida + 1 more
'Ken Yoshida' 'Carlo Colosimo'] Background/Objectives: Low-frequency alternating current (LFAC) has been shown to induce nerve conduction block (LFACb). However, the effects of LFAC on conduction delay prior to block remain unclear. This study investigates the impact of LFACb on conduction velocity and blocking…
Robert Egger, Yevhen Tupikov, Kalman A. Katlowitz, Sam E. Benezra + 5 more
Sequential activation of neurons has been observed during various behavioral and cognitive processes and is thought to play a critical role in their generation. Here, we studied a circuit in the songbird forebrain that drives the performance of adult courtship song. In this region, known as HVC, neurons are…
Caroline Mendonca Costa, Grace C. Anderson, Veronique M. F. Meijborg, Christopher O’Shea + 7 more
'Christopher O’Shea' 'Michael J. Shattock' 'Paulus Kirchhof' 'Ruben Coronel' 'Steven Niederer' 'Davor Pavlovic' 'Tarvinder Dhanjal' 'James Winter'] Background Re-entrant ventricular tachycardia may be non-inducible or haemodynamically compromising, requiring assessment of the electrophysiological properties of the…
Tim Hladnik, Jan Grewe
Studies on population coding implicitly assume that spikes from the presynaptic population arrive simultaneously at the integrating neuron. In natural neuronal populations, this is usually not the case — neuronal signalling takes time and neuronal populations cover a certain space. The spread of spike arrival times…
J. Xu, S. Xu, F. Wang, S. Xu
The signal delay during the propagation of action potentials is one of the key issues in understanding the mechanisms of generation and propagation of neural signals. Here we reanalyzed related experimental data to demonstrate that action potentials in the propagation process along a myelinated axon are highly…
Akihiko Akao, Sho Shirasaka, Yasuhiko Jimbo, Bard Ermentrout + 1 more
'Kiyoshi Kotani'] Cross-frequency coupling (CFC), where the amplitude of a fast neuronal oscillation is modulated by a second slower frequency, is thought to play an important role in long-range communication across distant brain regions. However, neither the mechanism of its generation nor the influence on spiking…
S. Berman, S. Filo, A. A. Mezer
Conduction of action potentials along myelinated axons is affected by their structural features, such as the axonal g-ratio, the ratio between the inner and outer diameters of the myelin sheath surrounding the axon. The effect of g-ratio variance on conduction properties has been quantitatively evaluated using…
Vladimir A. Ivanov, Ioannis Polykretis, Konstantinos P. Michmizos
— Increasing experimental evidence suggests that axonal action potential conduction velocity is a highly adaptive parameter in the adult central nervous system. Yet, the effects of this newfound plasticity on global brain dynamics is poorly understood. In this work, we analyzed oscillations in biologically plausible…
Afroditi Talidou, Paul W. Frankland, Donald Mabbott, Jérémie Lefebvre
Activity-dependent myelination is the mechanism by which myelin changes as a function of neural activity, and plays a fundamental role in brain plasticity. Mediated by structural changes in glia, activity-dependent myelination regulates axonal conduction velocity. It remains unclear how neural activity impacts…
Authors not listed
—Training transmission delays in spiking neural networks (SNNs) has been shown to substantially improve their performance on complex temporal tasks. In this work, we show that learning either axonal or dendritic delays enables deep feedforward SNNs composed of leaky integrate-and-fire (LIF) neurons to reach accuracy…
Matheus Hansen, Paulo R. Protachevicz, Kelly C. Iarosz, Iberê L. Caldas + 2 more
'Iberê L. Caldas' 'Antônio M. Batista' 'Elbert E. N. Macau'] We study the time delay in the synaptic conductance for suppression of spike synchronisation in a random network of Hodgkin Huxley neurons coupled by means of chemical synapses. In the first part, we examine in detail how the time delay acts over the network…
Santa Fukuda, Yuki Hayashida
Cathodic-first biphasic current pulses are commonly employed in intracortical microstimulation. Due to the intricate arrangement of axons, somata, and dendrites in the cerebral cortex, membrane polarizations induced by the cathodic and subsequent anodic phases of biphasic pulses may interact in a location-, magnitude-…
Alberto Saucedo, Amirreza Yousefzadeh, Guangzhi Tang, Federico Corradi + 2 more
'Federico Corradi' 'B. Linares-Barranco' 'Manolis Sifalakis'] The role of axonal synaptic delays in the efficacy and performance of artificial neural networks has been largely unexplored. In step-based analog-valued neural network models (ANNs), the concept is almost absent. In their spiking neuroscience-inspired…
Roy Meijer, Paul Detterer, Amirreza Yousefzadeh, Alberto Saucedo + 7 more
Accelerators Authors: ['Roy Meijer' 'Paul Detterer' 'Amirreza Yousefzadeh' 'Alberto Saucedo' 'Guoqiang Tang' 'Kanishkan Vadivel' 'Yan Xu' 'Manil Dev Gomony' 'Federico Corradi' 'B. Linares-Barranco' 'Manolis Sifalakis'] Abstract—Synaptic delay parameterization of neural network models have remained largely unexplored…
János Végh, Ádám József Berki
The payload performance of conventional computing systems, from single processors to supercomputers, reached its limits the nature enables. Both the growing demand to cope with "big data" (based on, or assisted by, artificial intelligence) and the interest in understanding the operation of our brain more completely…
Kartik Sau, Shigeyuki Takagi, Tamio Ikeshoji, Kazuaki Kisu + 5 more
All-solid-state battery (ASSB) is a possible alternative to the conventional Li-ion battery (LIB). ASSB, consisting of solid-fast-ion-conducting electrolytes and electrodes, can surpass LIB in terms of energy density, battery safety, specific power, and fast-charging capability. A highly conductive solid electrolyte is…