21 papers · ranked by Valyu relevance
Arun Cherkkil, Zoey Viavattine, Vamsy Kota, Kapil Saxena + 11 more
Understanding single-cell neuronal activity across multiple brain regions in the context of ethologically relevant behaviors is a major goal in systems neuroscience. We have engineered the Cortex Camera Array Microscope (CortexCAM), integrating four miniaturized fluorescence imaging microscopes to simultaneously…
G. Ball, S. Oldham, V. Kyriakopoulou, L. Z. J. Williams + 9 more
The third trimester of human gestation is characterised by rapid increases in brain volume and cortical surface area. A growing catalogue of cells in the prenatal brain has revealed remarkable molecular diversity across cortical areas.^1,2^ Despite this, little is known about how this translates into the patterns of…
Nicholas G Chehade
Motor cortex (M1) is a crucial brain area for controlling voluntary movements, such as reaching and grasping for a cup of coffee. M1 is organized in a somatotopic manner, such that M1 output driving movement to different parts of the body is organized along the cortical surface. In primates, the arm and hand are…
Hossein Haghir, Anika Kuckertz, Ling Zhao, Javad Hami + 1 more
'Nicola Palomero-Gallagher'] Neurotransmitters and their receptors are key molecules in information transfer between neurons, thus enabling inter-areal communication. Therefore, multimodal atlases integrating the brain’s cyto- and receptor architecture constitute crucial tools to understand the relationship between its…
Jeel Moya-Salazar, Hans Contreras-Pulache
This article presents a novel perspective on the structure and function of the human cortex, grounded in the Sociobiological Informational Theory (SIT). SIT offers a conceptual framework that integrates biological, psychological, and social dimensions of brain activity, challenging traditional anatomical and…
Lysea Haggie, Thor F. Besier, Angus J. C. McMorland
Computational models of cortical activity can provide insight into the mechanisms of higher-order processing in the human brain including planning, perception and the control of movement. Activity in the cortex is ongoing even in the absence of sensory input or discernible movements and is thought to be linked to the…
Heejung Jung, Xiaochun Han, Ma Feilong, Jane Han + 6 more
Cortical resources are allocated into systems specialized for processing ecologically relevant features of the world. These features are typically studied in isolation using controlled experimental stimuli, making it difficult to assess the relative importance of different kinds of features that tend to overlap during…
Noam Saadon-Grosman, Tsahi Asher, Yonatan Loewenstein
It is well-known that cortical areas specializing in the processing of somatosensory information from different parts of the body are arranged in an orderly manner along the cortex. It is also generally accepted that in the cortex, somatosensory information is initially processed in the primary somatosensory cortex and…
Peter Coppola
How subjective experience (i.e., consciousness) arises out of objective material processes has been called the hard problem. The neuroscience of consciousness has set out to find the sufficient conditions for consciousness and theoretical and empirical endeavours have placed a particular focus on the cortex and…
Cindy T. J. van Velthoven, Yuan Gao, Michael Kunst, Changkyu Lee + 29 more
The telencephalon of the mammalian brain comprises multiple regions and circuit pathways that play adaptive and integrative roles in a variety of brain functions. There is a wide array of GABAergic neurons in the telencephalon; they play a multitude of circuit functions, and dysfunction of these neurons has been…
Susumu Setogawa, Ryota Kanda, Shuto Tada, Takuya Hikima + 11 more
Characterization of inter-regional interactions in brain is essential for understanding the mechanism relevant to normal brain function and neurological disease. The recently developed flexible micro (μ)-electrocorticography (μECoG) device is one prominent method used to examine large-scale cortical activity across…
Mototaka Suzuki, Jaan Aru
Technological advances in the past decades have begun to enable neuroscientists to address fundamental questions about consciousness in an unprecedented way. Here we review remarkable recent progress in our understanding of cellular-level mechanisms of conscious processing in the brain. Of particular interest are the…
Muquan Yu, Mu Nan, Hossein Adeli, Jacob S. Prince + 5 more
'Leila Wehbe' 'Margaret M. Henderson' 'Michael J. Tarr' 'Andrew F. Luo'] | Muquan Yu1,2 | Mu Nan1 | Hossein Adeli3 | Jacob S. Prince4 | John A. Pyles5 | | --- | --- | --- | --- | --- | | Leila Wehbe6 | Margaret M. Henderson6 | | Michael J. Tarr6 | Andrew F. Luo†1 | | 1 University of Hong Kong | 2 Chinese University of…
William Saban, Shai Gabay
Researchers often attribute higher cognition to the enlargement of cortical regions throughout evolution, reflecting the belief that humans sit at the top of the cognitive pyramid. Implicitly, this approach assumes that the subcortex is of secondary importance for higher-order cognition. While it is now recognized that…
Agnès Gruart, José M. Delgado-García
This review presents a broad perspective of the Neuroscience of our days with special attention to how the brain generates our behaviors, emotions, and mental states. It describes in detail how unconscious and conscious processing of sensorimotor and mental information takes place in our brains. Likewise, classic and…
J. Matthijs Biesbroek, Marieke G. Verhagen, Stefan van der Stigchel, Geert Jan Biessels
'Geert Jan Biessels'] Title: Abstract The thalamus is a complex neural structure with numerous anatomical subdivisions and intricate connectivity patterns. In recent decades, the traditional view of the thalamus as a relay station and “gateway to the cortex” has expanded in recognition of its role as a central…
Zily Burstein, David D. Reid, Peter J. Thomas, Jack D. Cowan
While our understanding of the way single neurons process chromatic stimuli in the early visual pathway has advanced significantly in recent years, we do not yet know how these cells interact to form stable representations of hue. Drawing on physiological studies, we offer a dynamical model of how the primary visual…
Vladimir Shalgunov, Sara Irence Lopes van den Broek, Ida Vang Andersen, Rocío García Vázquez + 12 more
Vladimir Shalgunov 1 , Sara Lopes van den Broek 1 , Ida Vang Andersen 1 , Rocío García Vázquez 1 , Nakul Raval 1 , Mikael Palner 1 , Yuki Mori 1 , Gabriela Schäfer 2 , Hannes Mikula 3 , Natalie Beschorner 1 , Maiken Nedergaard 1 , Stina Syvänen 4 , Matthias Barz 2 , Gitte Moos Knudsen 1 , Umberto Maria Battisti 1 …
Jiwon Lee
Dopamine is a hormone that is released by the adrenal gland and influences motor control and motivation. Dopamine is known to have 5 receptors which are D1, D2, D3, D4 and D5, which are further categorized into 2 families: D1 family and D2 family. The D1 family is known to play a role in motivation and motor control…
Janet Sasso, Barbara Ambrose, Rumiana Tenchov, Ruchira Datta + 3 more
In the last decade, there has been a shift in research, clinical development, and commercial activity to exploit the many roles of RNA in physiology for use in medicine. With the rapid success in the development of lipid-RNA nanoparticles for mRNA vaccines against COVID-19 and with several approved RNA-based drugs, RNA…
Kim-Viktoria Bolik, Jan Hellmann, Simone Maschauer, Eduard Neu + 8 more
Background: The orexin receptor (OXR) plays a role in drug addiction and appears as a tumor marker in colon carcinoma. Subtype-selective OXR PET ligands have not yet been reported. The present work deals with the development of 18F-labeled OXR ligands dervived from selective OX1R antagonist JH112. Methods: Applying…