17 papers · ranked by Valyu relevance
Marius Rosier, George Stuyt, Luca Godenzini, Tomás J. Ryan + 1 more
The ability to associate stimuli to create a memory is one of the most fundamental functions of the brain. Research from the past decade has revealed that memory is encoded in sparse neuronal networks active during learning called engram cells. Although the cortex is recognized as playing an important role in memory…
Daniel Szelogowski
Despite substantial research into the biological basis of memory, the precise mechanisms by which experiences are encoded, stored, and retrieved in the brain remain incompletely understood. A growing body of evidence supports the engram theory, which posits that sparse populations of neurons undergo lasting physical…
Mujun Kim, Boin Suh, Yire Jeong, Sunhoi So + 4 more
How memories are shaped by repeated experiences remains unclear. Reorganization of memory engram could underlie memory transformation. Here, by combining c-Fos-based engram cell tagging with optogenetics, spine imaging, and reactivation analyses in the dentate gyrus (DG) and medial prefrontal cortex (mPFC), we…
Mark H. Histed
cortex Authors: ['Mark H. Histed'] Our brains encode many features of the sensory world into memories: we can sing along with songs we have heard before, interpret spoken and written language composed of words we have learned, and recognize faces and objects. Where are these memories stored? Each area of the cerebral…
Dheeraj S. Roy, Young-Gyun Park, Minyoung E. Kim, Ying Zhang + 11 more
Neuronal ensembles that hold specific memory (memory engrams) have been identified in the hippocampus, amygdala, or cortex. However, it has been hypothesized that engrams of a specific memory are distributed among multiple brain regions that are functionally connected, referred to as a unified engram complex. Here, we…
Kwok Yui Tony Yip, Johannes Gräff
A memory engram is thought to be the physical substrate of the memory trace within the brain, which is generally depicted as a neuronal ensemble activated by learning to fire together during encoding and retrieval. It has been postulated that engram cell ensembles are functionally interconnected across multiple brain…
Bryan D. Devan, Kyle Berger, Robert J. McDonald
Decades of research to localize an engram using various techniques in the past (Lashley, ; Thompson, , , ; Thompson et al., ; Mayford, ; Eichenbaum, ) has provided a foundation for the current state of engram research, expressed in a recent Forum (Poo et al., ). Different levels of organization of an engram were…
Douglas Feitosa Tomé, Sadra Sadeh, Claudia Clopath
Systems consolidation refers to the time-dependent reorganization of memory representations or engrams across brain regions. Despite recent advancements in unravelling this process, the exact mechanisms behind engram dynamics and the role of associated pathways remain largely unknown. Here we propose a…
Senka Hadzibegovic, Liangying Zhu, Melanie Ginger, Rafael De Sa + 5 more
Learning induces an early tag of prefrontal cortex neurons implicated in long-term memory storage, but this tag’s nature, functional role, and time course are unknown. Using a c-fos dependent genetic and viral system for the labeling and manipulation of putative engram neurons of the anterior cingulate cortex (ACC)…
Douglas Feitosa Tomé, Sadra Sadeh, Claudia Clopath
Systems consolidation refers to the reorganization of memory over time across brain regions. Despite recent advancements in unravelling engrams and circuits essential for this process, the exact mechanisms behind engram cell dynamics and the role of associated pathways remain poorly understood. Here, we propose a…
Dheeraj S. Roy, Young-Gyun Park, Sachie K. Ogawa, Jae H. Cho + 5 more
Neuronal ensembles that hold specific memory (memory engrams) have been identified in the hippocampus, amygdala, and cortex. It has been hypothesized that engrams for a specific memory are distributed among multiple brain regions that are functionally connected. Here, we report the hitherto most extensive engram map…
Omid Miry, Jie Li, Lu Chen
More than a century after Richard Semon's theoretical proposal of the memory engram, technological advancements have finally enabled experimental access to engram cells and their functional contents. In this review, we summarize theories and their experimental support regarding hippocampal memory engram formation and…
Yifei Mao
The algorithm of brain learning and memory is still undetermined. The backpropagation algorithm of artificial neural networks was thought not suitable for brain cortex, and there is a lack of algorithm for memory engram. We designed a brain version of backpropagation algorithm, which are biologically plausible and…
Lisa Blum Moyse, Hugues Berry
The standard consolidation theory states that short-term memories located in the hippocampus enable the consolidation of long-term memories in the neocortex. In other words, the neocortex slowly learns long-term memories with a transient support of the hippocampus that quickly learns unstable memories. However, it is…
Lucie Dixsaut, Johannes Gräff, Efthimios M. C. Skoulakis, Antonis Stamatakis
'Antonis Stamatakis'] It is becoming increasingly apparent that long-term memory formation relies on a distributed network of brain areas. While the hippocampus has been at the center of attention for decades, it is now clear that other regions, in particular the medial prefrontal cortex (mPFC), are taking an active…
Daniel Szelogowski
Despite success across diverse tasks, current artificial recurrent network architectures rely primarily on implicit hidden-state memories, limiting their interpretability and ability to model long-range dependencies. In contrast, biological neural systems employ explicit, associative memory traces (i.e., engrams)…
Hin Wai Lui
This paper proposes a theoretical framework for the biological learning mechanism as a general learning system. The proposal is as follows. The bursting and tonic modes of firing patterns found in many neuron types in the brain correspond to two separate modes of information processing, with one mode resulting in…