18 papers · ranked by Valyu relevance
Marius Rosier, George Stuyt, Luca Godenzini, Tomás J. Ryan + 1 more
The ability to associate stimuli to create a memory is one of the most fundamental functions of the brain. Research from the past decade has revealed that memory is encoded in sparse neuronal networks active during learning called engram cells. Although the cortex is recognized as playing an important role in memory…
Dheeraj S. Roy, Young-Gyun Park, Minyoung E. Kim, Ying Zhang + 11 more
Neuronal ensembles that hold specific memory (memory engrams) have been identified in the hippocampus, amygdala, or cortex. However, it has been hypothesized that engrams of a specific memory are distributed among multiple brain regions that are functionally connected, referred to as a unified engram complex. Here, we…
Douglas Feitosa Tomé, Sadra Sadeh, Claudia Clopath
Systems consolidation refers to the time-dependent reorganization of memory representations or engrams across brain regions. Despite recent advancements in unravelling this process, the exact mechanisms behind engram dynamics and the role of associated pathways remain largely unknown. Here we propose a…
PJ Banks, GRI Barker, CA Booth, L Kinnavane + 2 more
Associative recognition memory is essential for everyday life, forming cognitive representations of and recalling relationships between things we encounter and their environments. Object-place associations are represented in the lateral entorhinal and medial prefrontal cortices, however the identity of neurons in which…
Daniel Szelogowski
Despite substantial research into the biological basis of memory, the precise mechanisms by which experiences are encoded, stored, and retrieved in the brain remain incompletely understood. A growing body of evidence supports the engram theory, which posits that sparse populations of neurons undergo lasting physical…
Mujun Kim, Boin Suh, Yire Jeong, Sunhoi So + 4 more
How memories are shaped by repeated experiences remains unclear. Reorganization of memory engram could underlie memory transformation. Here, by combining c-Fos-based engram cell tagging with optogenetics, spine imaging, and reactivation analyses in the dentate gyrus (DG) and medial prefrontal cortex (mPFC), we…
Mark H. Histed
cortex Authors: ['Mark H. Histed'] Our brains encode many features of the sensory world into memories: we can sing along with songs we have heard before, interpret spoken and written language composed of words we have learned, and recognize faces and objects. Where are these memories stored? Each area of the cerebral…
Kwok Yui Tony Yip, Johannes Gräff
A memory engram is thought to be the physical substrate of the memory trace within the brain, which is generally depicted as a neuronal ensemble activated by learning to fire together during encoding and retrieval. It has been postulated that engram cell ensembles are functionally interconnected across multiple brain…
Senka Hadzibegovic, Liangying Zhu, Melanie Ginger, Rafael De Sa + 5 more
Learning induces an early tag of prefrontal cortex neurons implicated in long-term memory storage, but this tag’s nature, functional role, and time course are unknown. Using a c-fos dependent genetic and viral system for the labeling and manipulation of putative engram neurons of the anterior cingulate cortex (ACC)…
Lucie Dixsaut, Johannes Gräff, Efthimios M. C. Skoulakis, Antonis Stamatakis
'Antonis Stamatakis'] It is becoming increasingly apparent that long-term memory formation relies on a distributed network of brain areas. While the hippocampus has been at the center of attention for decades, it is now clear that other regions, in particular the medial prefrontal cortex (mPFC), are taking an active…
Xiaocen Fan, Jiachen Song, Chaonan Ma, Yanbo Lv + 3 more
'Lan Ma' 'Xing Liu'] The neocortical prefrontal memory engram generated during initial learning is critical for remote episodic memory storage, however, the nature of early cortical tagging remains unknown. Here we found that in mice, increased norepinephrine (NE) release from the locus coeruleus (LC) to the medial…
Maria Ayub, Antonello Mallamaci
In addition to orchestrate telencephalic development, the transcription factor Foxg1 is involved in mutual positive feedback with neuronal activity. Based on that, we hypothesized an involvement of it in learning and engram dynamics. We observed that its sparse and mild neuronal upregulation improved learning abilities…
Joaquín M. Fuster
Ever since it was discovered in the monkey’s prefrontal cortex, persistent neuronal activity during the delay period of delay tasks has been considered a phenomenon of working memory. Operationally, this interpretation is correct, because during that delay those tasks require the memorization of a sensory cue, commonly…
Lisa Blum Moyse, Hugues Berry
The standard consolidation theory states that short-term memories located in the hippocampus enable the consolidation of long-term memories in the neocortex. In other words, the neocortex slowly learns long-term memories with a transient support of the hippocampus that quickly learns unstable memories. However, it is…
Daniel Szelogowski
Despite success across diverse tasks, current artificial recurrent network architectures rely primarily on implicit hidden-state memories, limiting their interpretability and ability to model long-range dependencies. In contrast, biological neural systems employ explicit, associative memory traces (i.e., engrams)…
HaoRan Chang, Ingrid M. Esteves, Adam R. Neumann, Majid H. Mohajerani + 1 more
Episodic memory depends on the association of diverse attribute representations that are distributed across the neocortex, and evidence suggests that these attributes are linked, at least initially, by the hippocampus, which orchestrates retrieval and the offline replay of experience during memory consolidation. The…
Dhruvik Patel, Md. Sayed Tanveer, Jesus Gonzalez-Ferrer, Alon Loeffler + 3 more
NeuroAI is an emerging field at the intersection of neuroscience and artificial intelligence, where insights from brain function guide the design of intelligent systems. A central area within this field is synthetic biological intelligence (SBI), which combines the adaptive learning properties of biological neural…
Arno Granier, Katharina A. Wilmes, Mihai A. Petrovici, Walter Senn
Neuronal circuits of the cerebral cortex are the structural basis of mammalian cognition. The same qualitative components and connectivity motifs are repeated across functionally specialized cortical areas and mammalian species, suggesting a single underlying algorithmic motif. Here, we propose a perspective on current…