22 papers · ranked by Valyu relevance
Stella Sremic, Antea Krsek, Lara Baticic, Tibor Hortobágyi + 1 more
Deep brain stimulation (DBS) is an evolving neurosurgical treatment, originally developed for movement disorders such as Parkinson’s disease, essential tremor, and dystonia. In recent years, it has been increasingly applied to psychiatric and cognitive disorders. This review aimed to summarize the psychological and…
Fan Zhang, Yao Meng, Wei Zhang
Alzheimer’s disease is the most common type of cognitive disorder, and there is an urgent need to develop more effective, targeted and safer therapies for patients with this condition. Deep brain stimulation is an invasive surgical treatment that modulates abnormal neural activity by implanting electrodes into specific…
Akshay Reddy, Mohammad Reza Hosseini, Aashay Patel, Ramy Sharaf + 3 more
'Vishruth Reddy' 'Arman Tabarestani' 'Brandon Lucke-Wold'] Procedures for neurological disorders such as Parkinsons Disease (PD), Essential Tremor (ET), Obsessive Compulsive Disorder (OCD), Tourette's Syndrome (TS), and Major Depressive Disorder (MDD) tend to overlap. Common therapeutic procedures include deep brain…
Nathaniel P. Williams, Neetu Kushwah, Vaishnavi Dhawan, Xin Sally Zheng + 1 more
'Xin Sally Zheng' 'Xinyan Tracy Cui'] Over the past few decades, much progress has been made in the clinical use of electrical stimulation of the central nervous system (CNS) to treat an ever-growing number of conditions from Parkinson’s disease (PD) to epilepsy as well as for sensory restoration and many other…
Angelito A. Silverio, Lean Angelo A. Silverio
This work provides an overview of the present state-of-the-art in the development of deep brain Deep Brain Stimulation (DBS) and how such devices alleviate motor and cognitive disorders for a successful aging. This work reviews chronic diseases that are addressable via DBS, reporting also the treatment efficacies. The…
Vishal Jain, Mats Forssell, Pulkit Grover, Maysam Chamanzar
Non-invasive neuromodulation technologies have advanced considerably. Yet, precise and focal activation of deep brain regions remains challenging due to the rapid attenuation of electric fields across the scalp, skull and brain surface. We present FLOATES (FLOAting Transcranial Electrical Stimulation), a novel approach…
Xiaodong Liu, Fang Qiu, Lijuan Hou, Xiaohui Wang
Brain stimulation is a critical technique in neuroscience research and clinical application. Traditional transcranial brain stimulation techniques, such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and deep brain stimulation (DBS) have been widely investigated in…
Yuxin Guo, Mats Forssell, Dorian M. Kusyk, Vishal Jain + 7 more
Transcranial electrical stimulation (TES) is an effective technique to modulate brain activity and treat diseases. However, TES is primarily used to stimulate superficial brain regions and is unable to reach deeper targets. The spread of injected currents in the head is affected by volume conduction and the additional…
Svenja Treu, Bryan Strange, Simon Oxenford, Andrea Kühn + 2 more
Deep Brain Stimulation (DBS) is an established treatment option for movement disorders and is investigated to treat a growing number of other brain disorders. It has been shown that DBS effects are highly dependent on exact electrode placement, which is especially important when probing novel indications or…
Arkaprava Gupta, Justin E. Molloy, William Zellers, Prateek Ganguli + 4 more
Deep Brain Stimulation (DBS) has proven to be a promising treatment of Parkinson's Disease (PD). DBS involves stimulating specific regions of the brain's Basal Ganglia (BG) using electric impulses to alleviate symptoms of PD such as tremors, rigidity, and bradykinesia. Although most clinical DBS approaches today use a…
J. K. Trevathan, A. J. Asp, E. N. Nicolai, J. M. Trevathan + 9 more
After decades of study in humans and animal models, there remains a lack of consensus regarding how the action of electrical stimulation on neuronal and non-neuronal elements – e.g. neuropil, cell bodies, glial cells, etc. – leads to the therapeutic effects of neuromodulation therapies. To further our understanding of…
Yinpei Luo, Yuwei Sun, Xuelong Tian, Xiaolin Zheng + 5 more
'Weina Li' 'Xiaoying Wu' 'Bin Shu' 'Wensheng Hou'] Deep brain stimulation (DBS) is a neurosurgical technique that regulates neuron activity by using internal pulse generators to electrodes in specific target areas of the brain. As a blind treatment, DBS is widely used in the field of mental and neurological diseases…
Anna Franziska Frigge, Alexander Medvedev
— Deep Brain Stimulation (DBS) is a well-established neurosurgical treatment aiming at symptom alleviation in a range of neurological and psychiatric diseases. Computational models of DBS are widely used to investigate the effects of stimulation on neural tissue, to explore stimulation targets and sweetspots, and…
Yanan Sui, Huiling Yu, Chen Zhang, Yue Chen + 2 more
'Luming Li'] Title: Abstract Different from conventional brain-machine interfaces that focus more on decoding the cerebral cortex, deep brain-machine interfaces enable interactions between external machines and deep brain structures. They sense and modulate deep brain neural activities, aiming at function restoration…
Yongtong Wu, Peng Jia, Shenquan Liu
Deep brain stimulation (DBS) has become an effective intervention for advanced Parkinson's disease, but the exact mechanism of DBS is still unclear. In this review, we discuss the history of DBS, the anatomy and internal architecture of the basal ganglia (BG), the abnormal pathological changes of the BG in Parkinson's…
László B. Kish, Andrea Antal
synthesis Authors: ['László B. Kish' 'Andrea Antal'] A new type of non-invasive deep-brain stimulation is conceived and demonstrated by computer simulations. The process is based on spatio-temporal Fourier synthesis using multiple electrode pairs with sinusoidal current drive to limit skin sensations and concentrate…
Johannes Johansson
Background: Finite element method (FEM) simulations of the electric field magnitude (EF) are commonly used to estimate the affected tissue surrounding the active contact of deep brain stimulation (DBS) leads. Previous studies have found that DBS starts to noticeably activate axons at approximately 0.2 V/mm…
Xiaoyu Chen, Chencheng Zhang, Yuxin Li, Pei Huang + 5 more
Neural circuit-based guidance for optimizing patient screening, target selection and parameter tuning for deep brain stimulation (DBS) remains limited. To this end, we propose a functional brain connectome-based modeling approach that simulates network-spreading effects of stimulating different brain regions and…
WH Thompson, R Nair, H Oya, O Esteban + 5 more
Mapping the causal effects of one brain region on another (effective connectivity) is a challenging problem in neuroscience, since it requires invasive direct manipulation of brain function, together with whole-brain measurement of the effects produced. Here we establish a unique resource and present data from 26 human…
Anna Franziska Frigge, Elena Jiltsova, Fredrik Olsson, Dag Nyholm + 1 more
Patient Case Study Authors: ['Anna Franziska Frigge' 'Elena Jiltsova' 'Fredrik Olsson' 'Dag Nyholm' 'Alexander Medvedev'] Abstract— Deep Brain Stimulation (DBS) is a therapy widely used for treating the symptoms of neurological disorders. Electrical pulses are chronically delivered in DBS to a diseasespecific brain…
Markus Schütt, Jens Christian Claussen
Transcranial Electrical Stimulation (TCES) and Deep Brain Stimulation (DBS) are two different applications of electrical current to the brain used in different areas of medicine. Both have a similar frequency dependence of their efficiency, with the most pronounced effects around 100Hz. We apply superthreshold…
Ines R. Violante, Ketevan Alania, Antonino M. Cassarà, Esra Neufeld + 10 more
Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders however its invasiveness precludes widespread clinical use and deployment in research. Temporal interference (TI) is a strategy for non-invasive steerable DBS using multiple…