Search · four archives
Search · four archives
16 papers · ranked by Valyu relevance
Dean O. Smith, Julie L. Rosenheimer, Ronald E. Kalil, Brian McCabe
Background Because of the importance of voltage-activated K+ channels during embryonic development and in cell proliferation, we present here the first description of these channels in E15 rat embryonic neural progenitor cells derived from the subventricular zone (SVZ). Activation, inactivation, and single-channel…
Henry C. Tuckwell, Nicholas J. Penington
Serotonergic neurons of the dorsal raphe nucleus, with their extensive innervation of limbic and higher brain regions and interactions with the endocrine system have important modulatory or regulatory effects on many cognitive, emotional and physiological processes. They have been strongly implicated in responses to…
Wei-Ting Chang, Ping-Yen Liu, Zi-Han Gao, Shih-Wei Lee + 2 more
Remdesivir (RDV, GS-5734), a broad-spectrum antiviral drug in the class of nucleotide analogs, has been particularly tailored for treatment of coronavirus infections. However, to which extent RDV is able to modify various types of membrane ion currents remains largely uncertain. In this study, we hence intended to…
Juliette Boeri, Claude Meunier, Hervé Le Corronc, Pascal Branchereau + 7 more
Spontaneous neuronal activity occurs at the onset of the synaptogenesis in the central Nervous System and plays a major role in shaping developing neural networks. How intrinsic properties of neurons evolve during this critical developmental period remains largely unknown. We studied the Renshaw cells because they…
Tara L Klassen, Andrew N Spencer, Warren J Gallin
Background Voltage-gated ion channels are membrane proteins containing a selective pore that allows permeable ions to transit the membrane in response to a change in the transmembrane voltage. The typical selectivity filter in potassium channels is formed by a tetrameric arrangement of the carbonyl groups of the…
Briana M. Bohannon, Jessica J. Jowais, Leif Nyberg, Sara I. Liin + 1 more
Voltage-gated potassium (K_V_) channels are important regulators of cellular excitability and control action potential repolarization in the heart and brain. K_V_ channel mutations lead to disordered cellular excitability. Loss-of-function mutations, for example, result in membrane hyperexcitability, a characteristic…
Francisco J. H. Heras, John Anderson, Simon B. Laughlin, Jeremy E. Niven
Voltage-dependent conductances in many spiking neurons are tuned to reduce action potential energy consumption, so improving the energy efficiency of spike coding. However, the contribution of voltage-dependent conductances to the energy efficiency of analogue coding, by graded potentials in dendrites and non-spiking…
Edward Carmeliet
The aim of this review was to provide an overview of the most important stages in the development of cellular electrophysiology. The period covered starts with Bernstein's formulation of the membrane hypothesis and the measurement of the nerve and muscle action potential. Technical innovations make discoveries…
Dario Melgari, Chunyun Du, Aziza El Harchi, Yihong Zhang + 1 more
'Jules C. Hancox'] Title: Abstract Potassium channels encoded by human ether-à-go-go-related gene (hERG) mediate the cardiac rapid delayed rectifier K+ current (IKr), which participates in ventricular repolarization and has a protective role against unwanted premature stimuli late in repolarization and early in…
Melina Möller, Julian A. Schreiber, Mark Zaydman, Zachary Beller + 10 more
Loss-of-function mutations in K_v_7.1 often lead to long QT syndrome (LQTS), a cardiac repolarization disorder associated with increased risk of arrhythmia and subsequent sudden cardiac death. The discovery of agonistic I_Ks_ modulators may offer a new potential strategy in pharmacological treatment of this disorder.…
Xiaoan Wu, H. Peter Larsson
The delayed rectifier potassium IKs channel is an important regulator of the duration of the ventricular action potential. Hundreds of mutations in the genes (KCNQ1 and KCNE1) encoding the IKs channel cause long QT syndrome (LQTS). LQTS is a heart disorder that can lead to severe cardiac arrhythmias and sudden cardiac…
Hannah R. Martin, Anna Lysakowski, Ruth Anne Eatock
In amniotes, head motions and tilt are detected by two types of vestibular hair cells (HCs) with strikingly different morphology and physiology. Mature type I HCs express a large and very unusual potassium conductance, g_K,L_, which activates negative to resting potential, confers very negative resting potentials and…
Yangyang Lin, Sam Z. Grinter, Zhongju Lu, Xianjin Xu + 16 more
Cardiac arrhythmias are the most common cause of sudden cardiac death worldwide. Lengthening the ventricular action potential duration (APD) either congenitally or via pathologic or pharmacologic means, predisposes to a life-threatening ventricular arrhythmia, Torsade de Pointes. IKs, a slowly activating K^+^ current…
Predrag Janjic, Dimitar Solev, Ljupčo Kocarev
- Despite the molecular evidence that the nearly linear steady-state current-voltage relationship in mammalian astrocytes reflects a total current resulting from more than one differently regulated + conductances, detailed ODE models of membrane voltage are still lacking. Repeated experimental results of deregulated…
Daniele Andreucci, Dario Bellaveglia, Emilio N. M. Cirillo, Silvia Marconi
'Silvia Marconi'] We study the effect of intracellular ion diffusion on ionic currents permeating through the cell membrane. Ion flux across the cell membrane is mediated by special proteins forming specific channels. The structure of potassium channels have been widely studied in recent years with remarkable results…
Alexander Mayer, Owain Beynon, Andrew Logsdail, Upul Wijayantha + 6 more
Prussian Blue is widely utilized as a cathode material in batteries, due to its ability to intercalate alkaline metal ions, including potassium. However, the exact location of potassium or other cations within the complex structure, and how it changes as a function of cycling, is unclear. Herein, we report direct…